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Context: Value stream mapping (VSM) as a tool for lean development has led to significant improvements in different industries. In a few studies, it has been successfully applied in a software engineering context. However, some shortcomings have been observed in particular failing to capture the dynamic nature of the software process to evaluate improvements i.e. such improvements and target value

The autoantigen of endomysial antibodies in coeliac disease has been found to be an enzyme, tissue transglutaminase. Zinc inhibits the calcium-dependent activation of this thiol enzyme and also decreases the affinity between transglutaminase and the antibodies. Physiologically, transglutaminases catalyse the formation of bridges between lysine- and glutamine-containing peptides. Theoretically, if

De senaste åren har det blivit tydligt att detaljhandeln av idag måste hantera två förändringstryck: ökande internethandel och hållbarhetshänsyn. Hur fristående fysiska butiker och kedjor hanterar dessa tryck kommer att få avgörande betydelse för deras överlevnad. I detta kapitel argumenteras för att det finns en framtid för den fysiska butiken om miljöhänsyn tas på allvar ihop med de möjligheter

A whole genome scan to map quantitative trait loci (QTL) for persistency of milk yield (PMY), persistency of fat yield (PFY), persistency of protein yield (PPY) and persistency of milk energy yield (PEY) was performed in a granddaughter design in the German Holstein dairy cattle population. The analysis included 16 paternal half-sib families with a total of 872 bulls. The analysis was carried out

IMPORTANCE The positron emission tomography (PET) tracer [18F]flortaucipir allows in vivo quantification of paired helical filament tau, a core neuropathological feature of Alzheimer disease (AD), but its diagnostic utility is unclear. OBJECTIVE To examine the discriminative accuracy of [18F]flortaucipir for AD vs non-AD neurodegenerative disorders. DESIGN, SETTING, AND PARTICIPANTS In this cross-

Mild haemophilia is defined by factor levels between 0.05 and 0.40 IU/mL and is characterised by traumatic bleeds. Major issues associated with mild haemophilia are that it may not present for many years after birth, and that awareness, even within families, may be low. Methodological problems exist in diagnosis, such as inconsistencies in results obtained from different assays used to measure fac

This paper evaluates the utility of the feedback particle filter (FPF) for state estimation of SE(2)-configured dynamics in a real-time context. The filter is implemented in discrete time to fuse gyroscopic-and accelerometer measurements with Ultra-Wideband (UWB) and camera measurements. With this state information, the FPF is compared to other common filters in terms of the estimate mean square e

Membrane processes, antibiotics, enzymes, biofuels and biochemicalsThe end of the 20th century was marked by the start of the third and so far final wave of biotechnology, the so-called white biotechnology, aiming to substitute chemical processes based on C2/C3 chemistry of oil and gas by biotechnological processes. The standard conversion process in biotechnology is fermentation, which is used t

Objective: To describe the design and rationale for the genetic analysis of acute and chronic cerebrovascular neuroimaging phenotypes detected on clinical MRI in patients with acute ischemic stroke (AIS) within the scope of the MRI-GENetics Interface Exploration (MRI-GENIE) study. Methods: MRI-GENIE capitalizes on the existing infrastructure of the Stroke Genetics Network (SiGN). In total, 12 inte

Anisotropy of gravitational wave (GW) emission results in a net momentum gained by the black hole (BH) merger product, leading to a recoil velocity up to ∼103 km s−1, which may kick it out of a globular cluster (GC). We estimate GW kick retention fractions of merger products assuming different models for BH spin magnitude and orientation. We check how they depend on BH–BH merger time and propertie

The ambition of this two-part article is to argue for immanent critique as a research strategy in sustainability studies. We do this by picking up and developing two central, cross-cutting themes in sustainability research, namely interdisciplinarity and normativity. It is widely suggested that the problem-driven and solution-focused orientation in sustainability studies necessitates interdiscipli

The estimation of dynamic panel data models with interactive effects and moving average errors is considered. This is accomplished by making an extension to the factor analytical (FA) estimator which was originally designed for dynamic panels with fixed effects only and serially uncorrelated errors. The results show that the additional allowances have no effect on the asymptotic properties of the

An integrated flow-injection processing (FIP) system for the quantification of plasmids during cultivation is described. The system performs on-line sampling, cell lysis, and quantification of plasmids in an integrated manner during cultivation of E. coli. The system was operated by using a miniaturized expanded-bed column which can be used for handling samples containing cells and cell debris wit

Retinal pericytes play an important role in many diseases of the eye. Immunohistochemical staining techniques of retinal vessels and microvascular pericytes are central to ophthalmological research. It is vital to choose an appropriate method of visualizing the microvascular pericytes. We describe retinal microvascular pericyte immunohistochemical staining in cryo-sections, whole-mounts, and hypot

Studies conducted in historical populations and developing countries have evidenced the existence of clustering in infant deaths, which could be related to genetic inheritance and/or to social and cultural factors such as education, socioeconomic status or parental care. A transmission of death clustering has also been found across generations. One way of expanding the knowledge on intergeneration

Big Data Applications (BDAs) manage so much data to require a cluster of machines for computation and storage. Their execution often has temporal constraints, such as deadlines to process the data. BDAs are executed within Big Data Frameworks (BDFs), that provide mechanisms to automatically manage the complexity of the computation distribution. For a BDA to fulfill its deadline when executed in a

BACKGROUND: To investigate the outcome of an integrated individual and family therapy (Intensive Contextual Treatment: ICT) in terms of reducing suffering and increasing functional adjustment among self-harming and/or suicidal adolescents with high symptom loads and their families. METHODS: Forty-nine self-harming and/or suicidal adolescents, Mage = 14.6, of predominantly Swedish origin and female