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AimTo fully take advantage of blood test results, comparative data are required. Today, the reference interval is a commonly used concept. This review aims to summarise the current state of reference intervals, focusing on infants.MethodsLiterature on reference percentiles (birth to 12 months of age) published from January 1950 until November 2024 was reviewed. Search terms comprised paediatric, i
Industrial and urban symbiosis (IUS) is an emerging sustainability strategy in which organizations collaborate to optimize resource flows and minimize waste within urban environments. Rooted in circular economy principles, IUS has gained global attention as cities seek innovative solutions to enhance resource efficiency and resilience. However, local authorities play a critical yet underexplored r
Code review is a well-established and valuable software development practice associated with code quality, interpersonal, and team benefits. However, it is also time-consuming, with developers spending 10–20% of their working time doing code reviews. With recent advances in AI capabilities, there are more and more initiatives aimed at fully automating code reviews to save time and streamline softw
The advancement of disease-modifying treatments (DMTs) for Alzheimer's disease (AD), along with the approval of three amyloid-targeting therapies in the US and several other countries, represents a significant development in the treatment landscape, offering new hope for addressing this once untreatable chronic progressive disease. However, significant challenges persist that could impede the succ
We present an Unmanned Aerial Vehicle (UAV) human-robot interaction simulation environment to evaluate operator situational awareness (SA) during Beyond Visual Line of Sight (BVLOS) operations. We have developed a modular simulator that functions as a testbed for the design of custom scenarios and the study of human-robot interaction. This simulator facilitates data collection and allows for the c
Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states. Previous genetic studies have largely focused on insulin resistance in the fasting state, where hepatic insulin action dominates. Here we studied genetic variants influencing insulin levels measured 2 h after a glucose challenge in >55,000 participants from three ancestry groups. We identified ten new lo
Facebook is a frequently used Computer Mediated Environment (CME) for students and others to build social connections, with identities and deposited self-expression. Its widespread use makes it appropriate for consideration as an educational tool; though one that does not yet have clear guidelines for use. Whether a social networking site can be used for educational objectives remains largely unex
In this position paper we argue for a radical departure from today's approach to software engineering, centered on target-specific tools and general processes such as modeling and agile practices. The old principle of right tool for each problem shall be applied to software engineering as well: to address ever higher complexity, we need to raise dramatically the level of abstraction; as general so
In recent years, there is a growing interest for new lead-free oxides with reversible antiferroelectric (AFE)-ferroelectric (FE) phase transition for high-power energy-storage applications. NaNbO3-based ceramics are particularly attractive due to their easy synthesis and cost-effectiveness. In order to stabilize reversible AFE-FE phase transition, NaNbO3 is doped with a combination of heterovalent
This chapter addresses the organization known as the Satanic Reds, which was founded in the latter half of the 1990s by Tani Jantsang and Philip Marsh. The organization has been described as a ”virtual audience cult,” and even though it is clear that several people have contributed in shaping it, the organization has been especially influenced by its two founders. Jantsang and Marsh have spoken fo
The SP6 κ-promoter pentadecamer (pd) element was found to be unable to stimulate transcription when present in one copy as the only promoter element in a minimal promoter but showed weak stimulatory activity when present as a multimer (four copies). One copy of the pd element acted synergistically with an octamer element, but not with a SP1 site, to stimulate transcription. The effect was orientat
Background: Plasma soluble urokinase-type Plasminogen Activator Receptor (suPAR) predicts disease aggressiveness in renal cell carcinoma (ccRCC), but its prognostic accuracy has not been investigated. To investigate the prognostic accuracy of preoperative plasma suPAR in patients who received curative treatment for initially localized ccRCC. Methods: We retrospectively analyzed plasma samples stor
Despite the plethora of information on (S)-selective amine transaminases, the (R)-selective ones are still not well-studied; only a few structures are known to date, and their substrate scope is limited, apart from a few stellar works in the field. Herein, the structure ofLuminiphilus syltensis(R)-selective amine transaminase is elucidated to facilitate engineering towards variants active on bulki
Aims: To evaluate the cost-effectiveness of bimekizumab, an inhibitor of IL-17F and IL-17A, against biologic and targeted synthetic disease-modifying antirheumatic drugs (DMARD) for psoriatic arthritis (PsA) from the Swedish healthcare system perspective. Materials and methods: A Markov model was developed to simulate the clinical pathway of biologic [b] DMARD-naïve or tumor necrosis factor inhibi
