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Neuroprotective dobutamine treatment upregulates superoxide dismutase 3, anti-oxidant and survival genes and attenuates genes mediating inflammation

Background: Labor subjects the fetus to an hypoxic episode and concomitant adrenomodullary catecholamine surge that may provide protection against the hypoxic insult. The beta1-adrenergic agonist dobutamine protects against hypoxia/aglycemia induced neuronal damage. We aimed to identify the associated protective biological processes involved. Results: Hippocampal slices from 6 days old mice showed

Regional innovation systems and global flows of knowledge

The literature on regional innovation systems emphasizes the role of the region as locus for interactive learning and knowledge exchange, stressing the importance of (geographical) proximity for innovation. Even though the importance of extra-regional knowledge is widely acknowledged, there has been only little emphasis on the particular role and the nature of global knowledge flows. The aim of th

End-of-life treatments in pediatric patients at a government tertiary cancer center in India

Aim: The primary objective of this study was to describe demographics and end-of-life treatments of children with cancer at a government tertiary cancer center in India. Methods: A retrospective review was undertaken of medical charts of all children younger than 18 years, who died as inpatients while undergoing treatment at the pediatric oncology department between April and September 2016. Data

Reorienting health aid to meet post-2015 global health challenges : A case study of Sweden as a donor

The international development community is transitioning from the era of the Millennium Development Goals (MDGs), ending in 2015, to the era of the Sustainable Development Goals (SDGs), which have a 2030 target. Global development assistance for health (DAH) increased substantially in the MDGs era, from US $10.8 billion in 2001 to $28.1 billion by 2012 (in 2010 US dollars), and it played a crucial

Death rituals and quality of life of bereaved relatives during the COVID-19 pandemic : Results of the observational CO-LIVE study

Grief is a normal reaction after the death of a loved one. Death rituals are an integral part of the mourning processes. Not being able to carry out death rituals can affect relatives' quality of life. The aim was to evaluate death rituals during COVID-19 and their association with relatives' quality of life. In a Swedish nation-wide study relatives to persons who died during the COVID-19-pandemic

Validation of the Scandinavian guidelines for minor and moderate head trauma in children : protocol for a pragmatic, prospective, observational, multicentre cohort study

Introduction Mild traumatic brain injury is common in children and it can be challenging to accurately identify those in need of urgent medical intervention. The Scandinavian guidelines for management of minor and moderate head trauma in children, the Scandinavian Neurotrauma Committee guideline 2016 (SNC16), were developed to aid in risk stratification and decision-making in Scandinavian emergenc

Chemical analysis of combustion products from a high-pressure gas turbine combustor rig fueled by jet A1 fuel and a flscher-tropsch-based fuel

A comparative experimental investigation has been performed, comparing the emissions from a synthetic jet fuel and from Jet AI. In the investigation, the unburned hydrocarbons were analyzed chemically and the regulated emissions of NOX, CO and HC were measured. All combustion tests were performed under elevated pressures in a gas turbine combustor rig. A Swedish company, Oroboros AB, has developed

Improving narrative writing skills through observational learning: A study of Swedish 5th-grade students

Observational learning is a successful method for improving writing skills in various genres. We explore effects of a five lesson intervention series based on peer observation. Fifty-five Swedish 5th-grade students aged 10-12 years followed this intervention program. The language and reading comprehension and working memory capacity were tested. The students watched short film-clips with peers wor

Focal traumatic brain injury induces neuroplastic molecular responses in lumbar spinal cord

Background/Objectives: Motor impairment induced by traumatic brain injury (TBI) may be mediated through changes in spinal molecular systems regulating neuronal plasticity. We assessed whether a focal controlled cortical impact (CCI) TBI in the rat alters expression of the Tgfb1, c-Fos, Bdnf, and Gap43 neuroplasticity genes in lumbar spinal cord. Approach/Methods: Adult male Sprague-Dawley rats (n

Contribution of obesity associated genetic variants to anthropometric somatotype components

The somatotype is a useful method in the analysis of body morphology but no study has identified genetic variants associated with its components. The aim of this study is o replicate the association of 21 SNPs with obesity and to explore their association with the somatotype components, in a sample from the Basque Country (Spain). A case-control study was performed in 472 adults from 18 to 79 year

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Lifestyle factors are important for clinical outcome. Systematic and early identification of these factors is important in order to offer relevant lifestyle intervention programmes. The objective was to evaluate whether basic registration of risk factors was understandable, applicable and sufficient in the clinical workday.

The myeloid cell biomarker EMR1 is ectopically expressed in colon cancer

OBJECTIVE: The microenvironment of colon cancer (CC) is heterogeneous including cells of myeloid lineage affecting tumor growth and metastasis. Two functional subtypes of myeloid cells have been identified; one (M1) is tumor-inhibitory and the other one (M2) is tumor-promoting. Whether the three myeloid markers EMR1, CD206 and CD86 are expressed only in the infiltrating myeloid cells or also in th

Integrated Daylight and Energy Evaluation of Passive Solar Shadings in a Nordic Climate

Modern well-insulated and highly glazed buildings experience increased overheating, even in cold climates. The study focused on external and internal passive solar shadings on a south-oriented façade, having predetermined that external and internal shadings’ main function is solar heat gain and glare protection, respectively. A daytime-occupied office space with several external shading geometry v

MULTI-CRITERIA ASSESSMENT AND PROCESS SELECTION MODEL FOR ADDITIVE MANUFACTURING IN THE CONCEPTUAL PHASE OF DESIGN

Additive manufacturing (AM), which was first applied for rapid prototyping, is now becoming a real option for small-batch production of final products. Further expansion of AM is closely correlated to production costs. AM can only become competitive to traditional manufacturing methods if a product is designed for AM already from the beginning as it is an expensive technology that should only be a