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Group A Streptococcus (GAS) causes extensive global morbidity and rising rates of invasive disease, for which clinical outcomes remain poor despite antibiotic treatment of susceptible strains. This limitation of current therapy underscores the need for alternative or adjunctive approaches. Antibody-based interventions represent a promising but underexplored strategy. Historically, the streptococca

Introduction: Synovial fibroblasts (S-Fib) are recognized as key drivers of joint inflammation in adult arthritis. Moreover, data are limited on the processes driving monocyte activation in oligoarticular juvenile idiopathic arthritis (oJIA). Therefore, we aimed to explore if S-Fib from patients with oJIA induce monocyte activation. Methods: S-Fib were isolated from the synovial fluid (SF) of n =

Klimatet tar inte paus KLIMAT I FOKUS | Nr 02 • 2013 | LUNDS UNIVERSITET 2 KLIMAT I FOKUS | Nr 02 • 2013 Klimatet tar inte paus – de senaste 15 årens globala medeltemperaturtrend MARIANNE HALL, CENTRUM FÖR MILJÖ- OCH KLIMATFORSKNING, LUNDS UNIVERSITET MARKKU RUMMUKAINEN, CENTRUM FÖR MILJÖ- OCH KLIMATFORSKNING, LUNDS UNIVERSITET Under den specifika perioden 1998-2012 har den globala medeltemperatur

https://www.hallbarhet.lu.se/sites/hallbarhet.lu.se/files/temptrender_final_low.pdf - 2026-05-30

Variation of the blood content of the pulmonary vascular bed during a heartbeat can be quantified by pulmonary blood volume variation (PBVV) using magnetic resonance imaging (MRI). The aim was to evaluate if PBVV differs in patients with heart failure compared to healthy controls and investigate the mechanisms behind the PBVV. Forty-six patients and 10 controls underwent MRI. PBVV was calculated f

Introduction: Diabetic peripheral neuropathy (DPN) is a common complication of both type 1 (T1D) and type 2 diabetes (T2D). No cure for DPN is available, but several potential targets have been proposed for treatment. Heat shock proteins (HSPs) are known to respond to both hyper- and hypoglycemia. DPN can be diagnosed using electrophysiology and studied using peripheral nerve biopsies.Aim: This st

Epidemiological studies have associated plasma galectin-4 (Gal-4) levels with prevalent and incident diabetes, and with an increased risk of coronary artery disease. To date, data regarding possible associations between plasma Gal-4 and stroke are lacking. Using linear and logistic regression analyses, we tested Gal-4 association with prevalent stroke in a population-based cohort. Additionally, in

BACKGROUND: Gut microbiota have been implicated in atherosclerotic disease, but their relation with subclinical coronary atherosclerosis is unclear. This study aimed to identify associations between the gut microbiome and computed tomography-based measures of coronary atherosclerosis and to explore relevant clinical correlates.METHODS: We conducted a cross-sectional study of 8973 participants (50

Mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy techniques have been used extensively for metabolite profiling. Although combining these two analytical modalities has the potential of enhancing metabolite coverage, such studies are sparse. In this study we test the hypothesis that combining the metabolic information obtained using liquid chromatography (LC) MS and 1H NMR s

Mutations in a diverse set of driver genes increase the fitness of haematopoietic stem cells (HSCs), leading to clonal haematopoiesis1. These lesions are precursors for blood cancers2-6, but the basis of their fitness advantage remains largely unknown, partly owing to a paucity of large cohorts in which the clonal expansion rate has been assessed by longitudinal sampling. Here, to circumvent this

OBJECTIVE: To investigate the feasibility of synchrotron radiation-based phase contrast enhanced micro-computed tomography (SR-PhC-μCT) for imaging of human meniscus. Quantitative parameters related to fiber orientation and crimping were evaluated as potential markers of tissue degeneration.DESIGN: Human meniscus specimens from 10 deceased donors were prepared using different preparation schemes:

Aquaglyceroporin 7 (AQP7) facilitates glycerol flux across the plasma membrane with a critical physiological role linked to metabolism, obesity, and associated diseases. Here, we present the single-particle cryo-EM structure of AQP7 determined at 2.55 Å resolution adopting two adhering tetramers, stabilized by extracellularly exposed loops, in a configuration like that of the well-characterized in

Background:In early breast cancer, five histopathological biomarkers are part of current clinical routines and used for determining prognosis and treatment: estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor 2 (ERBB2/HER2), Ki67, and Nottingham histological grade (NHG). We aimed to develop classifiers for these biomarkers based on tumor mRNA-sequencing (RNA

Rapporten fokuserar på hur Covid-19 har påverkat olika samhällsviktiga verksamheter i Skåne. Verksamheterna har påverkats mycket, men det har inte uppstått allvarliga funktionsstörningar. Undantagen är Hälso- och sjukvård samt omsorg, och Transportsektorn där även funktionspåverkan förekommit I rapporten analyseras även hur förberedelser har skett och vilka lärdomar som kan dras av Covid-19.

Introduction: The use of medications in the general population has increased over time. Information on active metabolite concentrations for common drugs in the general population is limited. Recent advances in metabolomic technologies have made high-throughput profiling of many active metabolites in large epidemiological cohorts increasingly feasible.Aim: 1. Prospective assessment of the proportio

The human forebrain has expanded in size and complexity compared to chimpanzees despite limited changes in protein-coding genes, suggesting that gene expression regulation is an important driver of brain evolution. Here, we identify a KRAB-ZFP transcription factor, ZNF558, that is expressed in human but not chimpanzee forebrain neural progenitor cells. ZNF558 evolved as a suppressor of LINE-1 tran

Postadress Box 118, 221 00 Lund Besöksadress Astronomihuset, Sölvegatan 27 Telefon 046 - 2227184, 046-222 00 00 E-post ina.alexandersson@science.lu.se Webbadress www.naturvetenskap.lu.se Utb i ldn ingsnämnden Rapport 2022 - Kvalitetssäkring och kvalitets- utveckling inom utbildning på grundnivå och avancerad nivå Fakultetsstyrelsen har det samlade ansvaret för kvalitetssäkring och kvalitetsutveckl

https://www.naturvetenskap.lu.se/internt/sites/naturvetenskap.lu.se.internt/files/2024-01/Rapport%20%202022%20-%20Kvalitetssa%CC%88kring%20och%20kvalitetsutveckling%20inom%20utbildning%20pa%CC%8A%20grundniva%CC%8A%20och%20avancerad%20niva%CC%8A.pdf - 2026-05-30

Användarhandling för ISP-systemet för administratörer Sida 1 av 13 ANVÄNDARHANDLEDNING För administratörer 2020-09-14 Postadress Box 117, 221 00 Lund Besöksadress Sandgatan 13A, Lund Telefon 046-222 00 00 Webbadress www.sam.lu.se Användarhandling för ISP-systemet Institutions- och fakultetsadministratörer 1 Inledning .................................................................................

https://www.sam.lu.se/internt/sites/sam.lu.se.internt/files/2024-07/ISP%20anv%C3%A4ndarhandledning%20f%C3%B6r%20administrat%C3%B6rer%20200914_0.pdf - 2026-05-30

With a background in business, service, and sustainability, Felicia found the perfect fit in the Master’s in Sustainable Service Management. Today, she works as a sustainability advisor, helping companies improve their reporting and climate impact.