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Synovial monocytes contribute to chronic inflammation in childhood-onset arthritis via IL-6/STAT signalling and cell-cell interactions

INTRODUCTION: Monocytes are key effector cells in inflammatory processes. We and others have previously shown that synovial monocytes in childhood-onset arthritis are activated. However, very little is known about how they contribute to disease and attain their pathological features. Therefore, we set out to investigate the functional alterations of synovial monocytes in childhood-onset arthritis,

Genetic insights into resting heart rate and its role in cardiovascular disease

Resting heart rate is associated with cardiovascular diseases and mortality in observational and Mendelian randomization studies. The aims of this study are to extend the number of resting heart rate associated genetic variants and to obtain further insights in resting heart rate biology and its clinical consequences. A genome-wide meta-analysis of 100 studies in up to 835,465 individuals reveals

Size-resolved characterization of particles >10 nm emitted to air during metal recycling

Background: In the strive towards a circular economy, metal waste recycling is a growing industry. During the recycling process, particulate matter containing toxic and allergenic metals will be emitted to the air causing unintentional exposure to humans and environment. Objective: In this study detailed characterization of particle emissions and workplace exposures were performed, covering the fu

Correlation between ADC, ADC ratio, and Gleason Grade group in prostate cancer patients undergoing radical prostatectomy : Retrospective multicenter study with different MRI scanners

Background: MRI is an important tool in the prostate cancer work-up, with special emphasis on the ADC sequence. This study aimed to investigate the correlation between ADC and ADC ratio compared to tumor aggressiveness determined by a histopathological examination after radical prostatectomy.Methods: Ninety-eight patients with prostate cancer underwent MRI at five different hospitals prior to radi

Hur majoriteter kan ta kontroll över tillgångars avkastningsförmåga - En jämförelse mellan aktie- och inkråmsöverlåtelser ur ett aktieägarminoritetsperspektiv

En aktieägare i ett tillgångsägande aktiebolag, som vill få egenhändig kontroll över en tillgångs avkastningsförmåga, har idag två möjliga vägar att välja mellan för att uppnå sitt mål. Denne kan förvärva aktier i bolaget eller förvärva, direkt eller indirekt, själva tillgången. Beroende på vilken väg som väljs kommer aktieägaren stöta på olika typer av hinder. Denna uppsats syftar till att redogöA shareholder in an asset holding company, who wishes to gain direct control over the asset's capacity to produce profit, currently has two possible paths to choose from in order to achieve his or her goal. He or she can either acquire shares in the company or directly or indirectly acquire the asset itself. Depending on the chosen path, the shareholder will encounter different types of obstac

Kefalopoulou jama neurol

untitled Copyright 2013 American Medical Association. All rights reserved. Long-term Clinical Outcome of Fetal Cell Transplantation for Parkinson Disease Two Case Reports Zinovia Kefalopoulou, MD, PhD; Marios Politis, MD, PhD; Paola Piccini, MD, PhD, FRCP; Niccolo Mencacci, MD; Kailash Bhatia, MD, PhD; Marjan Jahanshahi, PhD; Håkan Widner, MD, PhD; Stig Rehncrona, MD, PhD; Patrik Brundin, MD, PhD;

https://www.wnc.lu.se/sites/wnc.lu.se/files/kefalopoulou_jama_neurol.pdf - 2026-06-19

Primary care detection of Alzheimer's disease using a self-administered digital cognitive test and blood biomarkers

After the clinical implementation of amyloid-β-targeting therapies for people with cognitive impairment due to Alzheimer's disease (AD), there is an urgent need to efficiently identify this patient population in primary care. Therefore, we created a brief and self-administered digital cognitive test battery (BioCog). Based on its sub-scores, a logistic regression model was developed in a secondary

Sex-Specific Cardiovascular Consequences of Long-Term High-Salt Diet in Mice

BACKGROUND: Excessive dietary salt intake is associated with elevated blood pressure and damage to organs including the heart, vasculature, and kidneys. Women are more prone to salt-sensitive hypertension, yet preclinical studies often focus on men.METHODS: To examine sex-specific responses to chronic salt loading, male and female C57Bl6/J mice were fed a high-salt diet (HSD; 8% NaCl) from 7 to 14

Microsoft Word - Riktlinjer Kandidatuppsatser VT 2017.doc

Microsoft Word - Riktlinjer Kandidatuppsatser VT 2017.doc Historiska institutionen Riktlinjer för uppsatsarbete på kandidatkursen - 2 - Innehåll ALLMÄNNA RIKTLINJER ............................................................................................... 3 UPPSATSKURSENS FUNKTION OCH MÅL .............................................................................3 Målet med uppsatskursen är

https://www.historiska.lu.se/media/utbildning/dokument/kurser/HISK01/20171/Riktlinjer_Kandidatuppsatser_VT_2017.pdf - 2026-06-19

AKAP-KR Överenskommelse om Avgiftsbestämd KollektivAvtalad Pension

AKAP-KR Överenskommelse om Avgiftsbestämd KollektivAvtalad Pension AKAP-KR Överenskommelse om Avgiftsbestämd KollektivAvtalad Pension ............................... ................................................................. .................. ...................................... .............................................................. ...............................................

https://www.saco.se/globalassets/lokala-akademikerforeningar/kommun-och-region/akademikeralliansen/dokument/avtal-stadgar-pension/akap-kr.pdf - 2026-06-19

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KOLLEKTIVAVTAL Revision- och konsultföretagen Avtal om allmänna villkor, arbetstid och kompetensutveckling 2021-01-01-2023-12-31 Akademikerförbunden har i förhandlingarna företrätts av Civilekonomerna. Civilekonomerna uppträder under innevarande avtalsperiod som gemensam representant för Akademikerförbunden. Central förhandling, vanligtvis efter lokal förhandling enligt MBL §§ 10- 12, begärs hos e

https://www.saco.se/globalassets/lokala-akademikerforeningar/privat/akademikerforbunden-aht/dokument/kollektivavtal/almega-revision--konsult-allmanna-villkor-20210101-20231231.pdf - 2026-06-19

Most gene fusions in cancer are stochastic events

Cancer-associated gene fusions resulting in chimeric proteins or aberrant expression of one or both partner genes are pathogenetically and clinically important in several hematologic malignancies and solid tumors. Since the advent of different types of massively parallel sequencing (MPS), the number of identified gene fusions has increased dramatically, prompting the question whether they all have

Endogenous expression mapping of malignant melanoma by mass spectrometry imaging

BACKGROUND: Currently, only a limited number of molecular biomarkers for malignant melanoma exist. This is the case for both diagnosing the disease, staging, and efficiently measuring the response to therapy by tracing the progression of disease development and drug impact. There is a great need to identify novel landmarks of disease progression and alterations.METHODS: Matrix-assisted laser desor

The role of metabolic syndrome in osteoarthritis development : Is obesity the key driver?

Objective: Investigate the role of metabolic syndrome and obesity in incident osteoarthritis (OA). Methods: Prospective cohort study with up to 11 years follow-up. From a general population cohort of 28,786 individuals from Sweden aged 45 to 75, we selected individuals without OA diagnosis and without joint pain during the year prior to the baseline. Metabolic syndrome was defined at baseline by t

CIM Verksamhetsrapp2022 Socialhögskolan

1 Lund den 20 januari 2023 Till institutionsstyrelsen, Socialhögskolan Lund Verksamhetsrapport för CIM på Socialhögskolan okt 2021 – dec 2022 Roberto Scaramuzzino, Anneli Nielsen och Helene Lahti Edmark CIM (Certificate of International Merits) är ett diplom vid sidan om examen som uppmärksammar internationella erfarenheter och aktiviteter som studenten varit involverad i under sin tid som student

https://www.soch.lu.se/sites/soch.lu.se/files/2023-02/CIM%20verksamhetsrapp2022%20Socialh%C3%B6gskolan.pdf - 2026-06-19

LPED 2020 2

Centre for Economic Demography Lund University School of Economics and Management P.O. Box 7083 SE-220 07 Lund, Sweden www.ed.lu/publications/Lund-Papers-in-Economic-Demography/ A Century of Divorce: Long-Term Socioeconomic Restructuring and the Divorce Rate in Sweden, 1915-2010 MARIA STANFORS, FREDRIK N G ANDERSSON, GLENN SANDSTRÖM LUND PAPERS IN ECONOMIC DEMOGRAPHY 2020:2 Copyright is held by th

https://www.lusem.lu.se/sites/lusem.lu.se/files/2024-07/LPED_2020_2.pdf - 2026-06-19

144 Salami PedDiab 2022

HbA1c as a time predictive biomarker for an additional islet autoantibody and type 1 diabetes in seroconverted TEDDY children OR I G I N A L A R T I C L E HbA1c as a time predictive biomarker for an additional islet autoantibody and type 1 diabetes in seroconverted TEDDY children Falastin Salami1 | Roy Tamura2 | Lu You2 | Åke Lernmark1 | Helena Elding Larsson1,3 | Markus Lundgren1,4 | Jeffrey Kris

https://www.teddy.lu.se/sites/teddy.lu.se/files/2023-03/144%20Salami_PedDiab_2022.pdf - 2026-06-19