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Heart failure (HF) is a major public health problem characterized by inability of the heart to maintain sufficient output of blood. The systematic characterization of circulating proteins across different stages of HF may provide pathophysiological insights and identify therapeutic targets. Here we report application of aptamer-based proteomics to identify proteins associated with prospective HF i
Myelodysplastic/myeloproliferative neoplasms, unclassifiable (MDS/MPN-U) are rare genetically heterogeneous hematologic diseases associated with older age and a poor prognosis. If the disease progresses into acute myeloid leukemia (AML), it is often refractory to treatment. To gain insight into genetic alterations associated with disease progression, whole exome sequencing and single nucleotide po
Alzheimer's disease is a neurodegenerative condition which involves heavy neuronal cell death linked to oligomers formed during the aggregation process of the amyloid β peptide 42 (Aβ42). The aggregation of Aβ42 involves both primary and secondary nucleation. Secondary nucleation dominates the generation of oligomers and involves the formation of new aggregates from monomers on catalytic fibril su
On-demand droplet generation from a continuously flowing stream of aqueous phase has profound applications in dropletbased microfluidics for rare event encapsulation studies. Here, we present acoustic relocation-based droplet generation from co-flowing immiscible fluids in an on-demand manner using bulk acoustic wave (BAW). After on-demand droplet generation, droplets are isolated using the same a
En analys av intervjuer som genomförts på Statens institutionsstyrelse LVM-hem i samband med att en person tvångsomhändertagits jmf LVM. Analysen är ett vetenskapligt underlag till SOU 2023:5 Från delar till helhet. Tvångsvården som en del av en sammanhållen och personcentrerad vårdkedja.
In a new episode of the podcast Ceteris Never Paribus, the host Maria Bach speaks to Evelina Kallträsk, David Larsson Heidenblad, Anna Nilsson Hammar and Johan Östling, all members of the Lund Centre for the History of Knowledge (LUCK). They discuss what is the history of knowledge and how its approaches might be useful for historians of economics.
BACKGROUND: The relation between blood pressure and kidney cancer risk is well established but complex and different study designs have reported discrepant findings on the relative importance of diastolic blood pressure (DBP) and systolic blood pressure (SBP). In this study, we sought to describe the temporal relation between diastolic and SBP with renal cell carcinoma (RCC) risk in detail.METHODS
Aims: In the present study, we aimed to evaluate the performance of machine learning (ML) models for identification of acute myocardial infarction (AMI) or death within 30 days among emergency department (ED) chest pain patients. Methods and results: Using data from 9519 consecutive ED chest pain patients, we created ML models based on logistic regression or artificial neural networks. Model input
Hormone secretion from pancreatic islets is essential for glucose homeostasis and loss or dysfunction of islet cells is a hallmark of type 2 diabetes. Maf transcription factors are critical for establishing and maintaining adult endocrine cell function. However, during pancreas development, MafB is not only expressed in insulin- and glucagon-producing cells, but also Neurog3+ endocrine progenitor
Som ett led i regeringsuppdraget att ”Utvidga kunskapen om barns läkemedel och deras användning” anordnade Läkemedelsverket 2012 ett möte med representanter för barn- och ungdomspsykiatrin. Syftet var att identifiera kunskapsluckor samt föreslå speciella läkemedelsområden där det fanns behov av att sammanställa kunskap. Behandling av sömnstörningar hos barn var ett område som prioriterades.
BACKGROUND AND PURPOSE: ECP (eosinophil cationic protein) is a marker of eosinophil activity and degranulation, which has been linked to atherosclerosis and cardiovascular disease. We examined the relationship between ECP, carotid plaque, and incidence of stroke in a prospective population-based cohort.METHODS: The subjects participated in the Malmö Diet and Cancer Study between 1991 and 1994. A t
Dietary carbohydrates have been implicated in relation to prostate cancer.
Firefighters can be occupationally exposed to a wide range of airborne pollutants during fire-extinguishing operations. The overall study aim was to characterize occupational exposure to smoke for several groups of workers responding to fires, with specific aims to determine the correlations between exposure markers and to biologically assess their systemic exposure to polycyclic aromatic hydrocar
ar. Enorma framsteg har gjorts de senaste decennierna i neonatalvården (vård för nyfödda barn) och omkring 80% av EPT-barn i Sverige överlever. Dessa framsteg innefattar bl.a. administrering av kortison för att påskynda lungmognaden, modern teknisk utrustning, bättre kunskaper om neonatala sjukdomar m.m. Globalt är överlevnaden av EPT-barn lägre i länder med sämre ekonomiska förutsättningar och däAim: To evaluate a pipeline for automatic MRI brain segmentation and volumetric tissue structure quantification in a cohort of extremely preterm infants. Methods: 13 extremely preterm neonates underwent MRI-scanning at a term equivalent age. Seven of these subjects had suitable MRI sequences and were analyzed in the pipeline. Segmentation of MRI brain images into brain tissue types and parcellati
The central theme of this thesis is anthropogenic climate change; governments' inability to create an effective, inclusive response mechanism that manages to mitigate anthropogenic emissions; and advocates efforts to coerce States to act by invoking State responsibility in adjudicatory dispute settlement processes. States' failure to act in accordance with scientific risk assessments and
Preclinical studies suggest that taurine may exert neuroprotective effects. However, its relevance to dementia risk in human populations remains unclear. We investigated the associations between mid-life dietary taurine intake, circulating taurine concentrations, and the risk of late-life all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VaD) in a large prospective cohort. This
Hydrodeoxygenation (HDO) is a catalytic process applied for the reduction of oxygen levels in hydrocarbons from bio-derived feedstock as part of the processing into renewable fuel. The MoS2-based hydrotreating catalysts, currently being applied for the HDO reaction, are exposed to a complex environment consisting of O-rich hydrocarbons and water, which adversely impacts the state and stability of
