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The purpose of this paper is to understand the relationship between the formal (governance established in law) and informal institutions (governance not established in law) that underpin the planning, operation and improvement of local and regional public transport, by using case studies of four countries: Britain (more specifically England, outside London); the Netherlands; Germany; and Sweden. T
Background and aim: Transport planning faces new demands for a dialogue with users. Transport planners no longer just build roads; nowadays they also must listen to users, whose wishes are meant to have an impact on the design and maintenance of the road transport system. Yet how can we know what users really want? This article sets out to analyze the methods with which transport planners gather i
PURPOSE: To validate metric optimized gating phase-contrast MR (MOG PC-MR) flow measurements for a range of fetal flow velocities in phantom experiments. 2) To investigate intra- and interobserver variability for fetal flow measurements at an imaging center other than the original site.METHODS: MOG PC-MR was compared to timer/beaker measurements in a pulsatile flow phantom using a heart rate (∼145
The Port of Rotterdam is an important industrial cluster mainly comprising of oil refining, chemical manufacturing and power and steam generation. In 2015, the area accounted for 18 % of the Netherlands' total CO2 emissions. The Port of Rotterdam Authority is aware that the port's economy is heavily exposed to future global and EU decarbonization policies, as the bulk of its activities focuses on
Remote homology detction among proteins in an unsupervised approach from sequences is an important problem in computational biology. The existing neighborhood cluster kernel methods and Markov clustering algorithms are most efficient for homolog detection. Yet they deviate from random walks with inflation or similarity depending on hard thresholds. Our spectral clustering approach with new combine
A total of 1 130 bulls belonging to 20 half-sib families of German dairy cattle were genotyped for 229 microsatellite markers on 30 chromosomes. The data were used in an attempt to map quantitative trait loci applying regression as multiple-marker regression. For association analysis with a granddaughter design, the estimated breeding values for 3 milk traits were used: milk production, fat produc
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the efficacy and tolerability of pharmacological interventions for the treatment of CSWS and LKS.
Context: Several drugs are approved and available for the treatment of lower urinary tract symptoms (LUTS) in men and women. However, the vast majority of available data, upon which the approval and recommendation in guidelines are based, considered only the role of the monotherapies and did not evaluate possible combination therapies. Objective: This systematic review analyzes the efficacy and ad
Background: Criteria for electrocardiographic detection of acute myocardial ischemia recommended by the Consensus Document of ESC/ACCF/AHA/WHF consist of two parts: The ST elevation myocardial infarction (STEMI) criteria based on ST elevation (ST↑) in 10 pairs of contiguous leads and the other on ST depression (ST↓) in the same 10 contiguous pairs. Our aim was to assess sensitivity (SE) and specif
In this work, we investigated muonic atoms and molecules from a quantum chemist's viewpoint by incorporating muons in the CASSCF model. With the aim of predicting muonic X-ray energies, primitive muonic basis sets were developed for a selection of elements. The basis sets were then used in CASSCF calculations of various atoms and molecules to calculate muonic excited states. We described the influ
GCMs (general circulation models) are main tools for generating climate projections for climate change research in hydrology and water resources. Accordingly, evaluating the performance of these models in simulating future climate is very important for choice of proper models. In this study, performance of 20 Coupled Model Intercomparison Project Phase 5 (CMIP5) model series was assessed using a t
A framework is proposed for modelling the uncertainty in the measurement processes constituting the dosimetry chain that are involved in internal absorbed dose calculations. The starting point is the basic model for absorbed dose in a site of interest as the product of the cumulated activity and a dose factor. In turn, the cumulated activity is given by the area under a time–activity curve derived
Background: Reproducible quantification of drug transporter protein expression in tissues is important for predicting transporter mediated drug disposition. Many mass-spectrometry based transporter protein quantification methods result in high variability of the estimated transporter quantities. Therefore, we aimed to evaluate and optimize mass spectrometry-based quantification method for drug tra
In the last decades, nanotechnology has played a key role in the electrochemical biosensor development based on the mediated and direct electrochemical communication between the biorecognition elements and the electrode surface. In particular, graphene and 2D-like nanomaterials (e.g., boron nitride nanosheets, graphitic carbon nitride (g-C3N4) nanosheets, and various transition metal dichalcogenid
This paper elucidates a disciplinary context for an emergent buildingtype dubbed Accessory Dwelling Unit, or ADU. Today, ADU developmentsadd density to metropolitan Los Angeles by undermining the low densityprinciples of single-family residential zoning. Surfacing withinthe jurisdiction formally known as the City of Los Angeles, the ADUsupplements city planning in the transformation of suburbia. T
A reduction in the number of postoperative bed days for patients who underwent appendectomy led to a study of changes in hospital costs of appendectomies for the years 1955, and 1965, and 1975. No significant changes were found in the total hospital costs. However, the postoperative costs decreased by 36 percent from 1955 to 1975 due to a decrease in the mean duration of hospital stay. During the
