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The cohesin ring, which is composed of the Smc1, Smc3, and Scc1 subunits, topologically embraces two sister chromatids from S phase until anaphase to ensure their precise segregation to the daughter cells. The opening of the ring is required for its loading on the chromosomes and unloading by the action of Wpl1 protein. Both loading and unloading are dependent on ATP hydrolysis by the Smc1 and Smc

A key task in the ESMERALDA project dealt with identifying appropriate case studies to test the ‘flexible methodology’ in its different stages of development. Case studies consist of working examples in which mapping and assessment of ecosystem services were applied to address specific decision-making problems. Testing is understood as an iterative process of co-learning that involves project part

Question: How does reproductive timing in annual social insects evolve under intraspecific exploitation competition and in response to a changing environment? The latter includes shifts in resource abundance, mortality, season length, and resource peak timing, factors often associated with climate change. Background: Climate and land use are changing. Evolutionary ecology must learn to predict how

A new approach to understanding the interaction between cortical areas is provided by a mathematical analysis of biased competition, which describes many interactions between cortical areas, including those involved in top-down attention. The analysis helps to elucidate the principles of operation of such cortical systems, and in particular the parameter values within which biased competition oper

Bokanmälan av Yishai Beer: Military Professionalism and Humanitarian Law. The Struggle to Reduce the Hazards of War. New York NY: Oxford University Press, 2018. ISBN 978-0-19-088114-6

The aim of this work is the development of a thermodynamically consistent fully coupled thermo-viscoplastic material model for metals undergoing finite deformation and large temperature changes.The deformation gradient is supposed to be decomposable into a thermal, an elastic, and a plastic part, where purely volumetric thermal expansion and isochoric plastic distortion is assumed. The model is ba

Intermodality or combining more than one transport mode during a single trip has been put forward to facilitate a modal shift from private car to more environmentally friendly modes such as public transport, cycling or walking. Bike-and-ride – that is, integrating cycling and public transport in one trip – is an attractive combination, as cycling as an active and clean mode is faster than walking

Pavement data collection is the most expensive and time consuming component of Pavement Management System (PMS). Thus, possible methods of minimizing the need of such data might be critical in reducing pavement condition monitoring costs. Also the ability to relate pavement performance prediction models (frequently roughness based) to hot mix asphalt field performance models (distress based) provi

The rapid accumulation of ancient human genomes from various areas and time periods potentially enables the expansion of studies of biodiversity, biogeography, forensics, population history, and epidemiology into past populations. However, most ancient DNA (aDNA) data were generated through microarrays designed for modern-day populations, which are known to misrepresent the population structure. P

Boken Att dikta för livet, döden och evigheten har fokus på perioden 1500 till 1800 och på svensk tillfällesdiktning insatt i sitt nordeuropeiska sammanhang. Fältet är representativt och omfattande. Vi har lyckats intressera forskare inte bara från Sverige utan även från Danmark, Island, Finland, Estland, Ryssland och Tyskland att medverka med artiklar, vilket varit av avgörande vikt med tanke på

Sustainability challenges are defined by their complex and multifaceted interactions between nature and society and contention as to how and where to direct problem-solving efforts. This chapter presents four different approaches that exist for framing sustainability challenge areas that are introduced and worked with by students in LUMES International Master Programme in Environmental Studies and

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we h

The Swedish Strategic Innovation Agenda for Geoenergy develops a strategy for highlighting the need for geoenergy research, development and innovation in relation to the business community and authorities. Sweden has a strong global position in the field. Geothermal energy is the third­largest renewable energy source in Sweden, along with wind power. Currently, approximately 18 TWh of renewable he

Modal choice is a prominent concept within transport studies. However, the term is often used quite loosely, with little known about the factors lying behind the choice, the alternatives available to a person, and whether the person had a ‘choice’ to begin with. This study draws on a travel survey among older people living in Sweden’s large metropolitan regions. The questions posed as part of this

Lean Startup has been impacting how startups and incumbents innovate their business models. However, academic understanding of Lean Startup and the associated experimentation process is only emerging. Recent academic critique of Lean Startup by Felin and colleagues (in press) highlights the inadequate guidance provided for hypotheses generation; limits of experiential learning from customer feedba