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Streptococcus pyogenes infects over 700 million people worldwide annually. Immune evasion strategies employed by the bacteria include binding of the complement inhibitors, C4b-binding protein (C4BP) and Factor H in a human-specific manner. We recently showed that human IgG increased C4BP binding to the bacterial surface, which promoted streptococcal immune evasion and increased mortality in mice.
The YPEL family genes are highly conserved across a diverse range of eukaryotic organisms and thus potentially involved in essential cellular processes. Ypel4, one of five YPEL family gene orthologs in mouse and human, is highly and specifically expressed in late terminal erythroid differentiation (TED). In this study, we investigated the role of Ypel4 in murine erythropoiesis, providing for the f
The aim of this thesis was to analyze and compare the effects of various types of speed-reducing measures (speed humps, raised pedestrian and cycle crossings, dynamic speed bumps, and combined solutions) on vehicle speeds and traffic safety on selected streets in Helsingborg, Sweden. The study focused on residential streets, school zones, and main roads with different traffic environments. The met
