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In the wake of the globalization, international tax planning structures has become vital for US investors in order to meet economic challenges and to survive on the competitive market. This research indicates that countries in Europe, such as Sweden and Switzerland, provide a favourable environment for US multinational corporations to set up holding companies as a way to enjoy benefits of legal ta
This article is a collective response to the 2020 iteration of The Manifesto for Teaching Online. Originally published in 2011 as 20 simple but provocative statements, the aim was, and continues to be, to critically challenge the normalization of education as techno-corporate enterprise and the failure to properly account for digital methods in teaching in Higher Education. The 2020 Manifesto cont
Aims: Stratifying renal damage in type 2 diabetes is challenging due to overlapping features between diabetic nephropathy (DN) and non-diabetic renal disease (NDRD). While miR-27b-3p modulates kidney fibrosis in DN through the lysine63 ubiquitination pathway, its upstream regulation and diagnostic relevance remain unclear. Methods: In a biopsy-verified cohort of 231 chronic kidney disease (CKD) pa
Objective: To implement artificial neural network (ANN) algorithms for noninvasive lymph node staging (NILS) to a decision support tool and facilitate the option to omit surgical axillary staging in breast cancer patients with low-risk of nodal metastasis. Methods: The NILS tool is a further development of an ANN prototype for the prediction of nodal status. Training and internal validation of the
Diabetic patients suffer from macro- and microvascular complications causing increased morbidity and mortality. How hyperglycemia provokes vascular damage remains unclear, but glucose is believed to fuel a harmful low-grade chronic inflammation of the vessel wall. Previous work showed that glucose activates the transcription factor Nuclear Factor of Activated T cells (NFAT) in arteries ex vivo. NF
Introduction: Community Case Management (CCM) aims to improve health outcomes among children under five with malaria, diarrhea, and pneumonia, but its effectiveness in Malawi is limited by inconsistent standards of delivery characteristic of paper-based interventions. This may lead to negative impacts on child health outcomes and inefficient use of health system resources. This study evaluated the
OBJECTIVES: Patient-reported outcome measures (PROMs) are important for clinical practice and research. Given the high unmet need, our aim was to develop a comprehensive PROM for systemic sclerosis (SSc), jointly with patient experts. METHODS: This European Alliance of Associations for Rheumatology (EULAR)-endorsed project involved 11 European SSc centres. Relevant health dimensions were chosen an
Tourism is an industry with considerable environmental and social impacts; in order to stimulate reduction of these impacts, voluntary recognition schemes i.e. ecolabels and certification programmes have been introduced to motivate tourism businesses to improve their environmental performance, encourage more sustainable practices and patterns in this branch of economy, provide information to touri
Islands? characteristics provide several advantages as laboratory for studying 100% renewable energy sources (RES) systems. Their isolation makes them a ?unique laboratories, to gain knowledge and understanding of people/environment relationships? ; to prove its feasibility and acquire the needed knowledge for such systems to work; to be pioneer project, basis of other islands? projects and even a
Due to the development of technology, the value of the IP protected goods increases, and so does the harm done by the infringers. The TRIPS Agreement expressly provides for criminal sanctions for the serious cases of trademark counterfeiting and copyright piracy where the offences are committed willfully and on commercial scale. The TRIPS Agreement also reserves a possibility for introduction of m
PURPOSE The purpose of this thesis is to investigate why companies currently are not using social media for IR in Sweden. More specific, we are studying driving and inhibiting factors that are influencing Swedish companies to use, or not to use, this communication technology for IR. METHOD Our thesis addresses the attitudes towards using social media for IR among Swedish companies listed on the OM
Purpose: To compare collagenase injection with surgical fasciectomy in Dupuytren disease (DD) for the prevalence of contracture in treated fingers 5 years after treatment. Methods: This was a single-center, comparative cohort study comprising 2 cohorts of patients treated for DD in 1 or more of 3 ulnar fingers with collagenase injection (159 patients) or surgical fasciectomy (59 patients). At 5 ye
There remains a knowledge gap concerning the persistence of attention deficit hyperactivity disorder (ADHD) over the longer term. The current study aimed to investigate the change in parent-rated, and performance-based metrics of executive functioning (EF) and the relationship between these EF metrics and ADHD symptoms in individuals with ADHD from childhood/adolescence to young adulthood. This wa
Despite laws, policies and visions to create cities and societies for all, barriers still exclude persons with disabilities from using buildings and public places. Our study aimed to identify choices made during the urban development process that include or exclude users in the built environment; how and when these choices arise during the process; and what is needed to implement universal design
At present, the Global Stratotype Section and Point (GSSP) for the base of the Bartonian remains the only GSSP of the Paleogene System to be defined by the International Subcommission on Paleogene Stratigraphy (ISPS) and the International Commission on Stratigraphy (ICS). Here, we present the results of an integrated, high-resolution study of calcareous plankton and benthic foraminifera biostratig
Abstract in Portuguese:Referências a paisagens e lugares são elementos centrais nas narrativas tradicionais de falantes da língua Dâw (Naduhup,Amazônia brasileira). Essa ênfase na referência espacial é estabelecida principalmente por meio de orações adverbiaislocativas que são frequentemente repetidas ao longo do discurso. Sua função é relacionar um evento a um lugar, estabelecerreferência à inforReferences to landscape and places are central in traditional narratives by speakers of Dâw (Naduhup, Brazilian Amazon). This emphasis on spatial reference is primarily established through locative adverbial clauses that are often repeated throughout the discourse. Their function is to relate an event to a place, establish reference to locative information mentioned earlier in discourse, and provi
