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Deep metabarcoding offers an efficient and reproducible approach to biodiversity monitoring, but noisy data and incomplete reference databases challenge accurate diversity estimation and taxonomic annotation. Here, we introduce a novel algorithm, NEEAT, for removing spurious operational taxonomic units (OTUs) originating from nuclear-embedded mitochondrial DNA sequences (NUMTs) or sequencing error

A multi-variable adaptive controller is derived as the explicit solution to a minimax dynamic game. The minimizing player selects the control action as a function of past state measurements and inputs. The maximizing player selects disturbances and model parameters for the underlying linear time-invariant dynamics. This leads to a Bellman equation that can be solved explicitly for the case with un

A blood biomarker-based staging system for Alzheimer’s disease (AD) could improve the diagnosis, prognosis and identification of individuals most likely to benefit from specific therapies. Here, using targeted mass spectrometry, we measured six phosphorylated and six nonphosphorylated tau peptides in plasma from two independent cohorts: BioFINDER-2 and TRIAD (n = 689). We also analyzed the ratios

In the era of artificial intelligence of things (AIoT), distributed processing on local devices is growing in popularity. This stems from the need to reduce data transfer to and from central servers, with concerns about privacy and latency encouraging the processing of AI applications on edge devices. However, the computational demands of these applications require an increase in the processing ca

The number of degrees of freedom (NDoF) in a communication channel fundamentally limits the number of independent spatial modes available for transmitting and receiving information. Although the NDoF can be computed numerically for specific configurations using singular value decomposition (SVD) of the channel operator, this approach provides limited physical insight. In this paper, we introduce a

Model-based design is an emerging tool for dealing with the uncertain dynamic loads entering wastewater treatment plants (WWTPs). But our understanding about the load-driving population-dynamics is limited. Therefore, we studied if mobility data (mobile telecommunications data) could be used to reduce uncertainties during design. Mobility data from Uppsala, Sweden between 2019–2022 clearly quantif

Simple surrogate fuels are needed to model practical fuels, which are complex mixtures of hydrocarbons. The surrogate fuel should match the combustion and emissions behaviour of the target fuel as much as possible. This paper presents experimental results using a wide range of fuels in both the gasoline and diesel auto-ignition range, but of different volatilities and compositions, in a single cyl

Papillon-Lefevre syndrome (PLS) results from mutations that inactivate cysteine protease cathepsin C (CTSC), which processes a variety of serine proteases considered essential for antimicrobial defense. Despite serine protease-deficient immune cell populations, PLS patients do not exhibit marked immunodeficiency. Here, we characterized a 24-year-old woman who had suffered from severe juvenile peri

Terrestrial ecosystems currently sequester about one third of anthropogenic CO 2 emissions each year, an important ecosystem service that dampens climate change. The future fate of this net uptake of CO 2 by land based ecosystems is highly uncertain. Most ecosystem models used to predict the future terrestrial carbon cycle share a common architecture, whereby carbon that enters the system as net p

Medications are of considerable help if healthcare providers are able to administer them to patients safely and appropriately. The medication use process is complex and a team of professionals – doctors, nurses, and pharmacists – work together with the patient for optimal treatment effect. The process involves many sub-processes and in every step there is a possibility for an error. Cytotoxic drug

Various pre-treatments (acid, alkaline, enzyme and alkaline aided enzyme also termed combined) were evaluated on different fractions of bamboo waste from a chopstick production factory. Chemical oxygen demand (COD) solubilisation, monomeric/dimeric sugar yield, methane yield enhancement and methane production rate were assessed. The biochemical methane potential was determined in batch assays unde

A common application of nanometer-sized gold particles is as seed particles for growth of semiconductor nanowires, which are believed to act as highly promising building blocks in future electronic devices. In a majority of the reports of successful nanowire growth, gold has been the seed particle material of choice. In this review article we identify the different types of gold particles used to

A programme has been started to investigate photon properties that are not currently exploited in astronomical instruments, namely second- and higher-order coherence functions encoded in their arrival time, and the orbital angular momentum. This paper expounds the first results achieved in the study of a novel astronomical photometer capable of pushing time tagging towards the picosecond region. T

The mechanical integrity of tin-doped indium oxide (ITO) thin films sputtered onto a high temperature aromatic polyester developed for flexible display applications was investigated by means of tensile experiments equipped with electrical measurement, and carried out in-situ in an optical microscope. Attention was paid to the influence of ITO thickness, composition and crystalline microstructure,

PURPOSE OF REVIEW: Dissecting the genetics of complex polygenic diseases in which environmental factors interact with genetic variants in the predisposition to the disease has not been a trivial task and success has been limited. The purpose of this review is to provide insights into recent advances in genetics of type 2 diabetes. RECENT FINDINGS: In the past year, together the consortia of severa

Arm lymphedema is a well-known side effect of breast cancer treatment. Studies of the effect of physical exercise on arm lymphedema are very rare. The purpose of this study was to investigate the influence of pole walking on breast cancer-related arm lymphedema when using a compression sleeve. Twenty-six women with unilateral arm lymphedema took part in a clinical study of pole walking on one occa