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Plasma-membrane Ca2+-ATPases expel Ca2+ from the cytoplasm and are key regulators of Ca2+ homeostasis in eukaryotes. They are autoinhibited under low Ca2+ concentrations. Calmodulin (CaM)-binding to a unique regulatory domain releases the autoinhibition and activates the pump. However, the structural basis for this activation, including the overall structure of this calcium pump and its complex wi
This paper presents a scalable and high-Throughput hybrid computing platform for the real-Time multi-particle based Linac (Linear accelerator) simulation model to be used at the European Spallation Source (ESS). The multi-particle simulation model with non-linear modeling is needed to provide a realistic behavior of the particle beam for reducing the losses at the superconducting structures. The c
Nitrogenase is the only enzyme that can cleave the triple bond in N2, making nitrogen avaiable for other organisms. It contains a complicated MoFe7S9C(homocitrate) cluster in its active site. Many computational studies with density-functional theory (DFT) of the nitrogenase enzyme have been presented, but they do not show any consensus-they do not even agree where the first four protons should be
Purpose: Applying diffusion and perfusion metrics for evaluation of low-(LGG), high grade glioma (HGG) and metastases (MET) for differential diagnosis. Materials and Method: 43 patients (18HGG, 10 LGG, and 15MET) were included. MR data for tumour volume, perilesional edema, rCBF-, rCBV-, FLAIR-, FA-, ADC-maps were quantified by regions of interest (ROI). Measures of different parameters, and ratio
The study and development of a decision support system for doctors and students is presented, aiming to ease the diagnosis of the cervix cancer through an automated smart system: using a web application, a medical expert can upload colposcopic images feeding an expert system that carries out a deep analysis by a processing system on images uploaded by doctors; results coming out of the processing
Invasive extravillous cytotrophoblast of the human placenta expresses galectins-1, -3, and -8 in vivo and in vitro. This study aimed to investigate the potential role of galectin-3 in cell migration and invasion, using recombinant human galectin-3 (rhgalectin-3), small molecule galectin inhibitor I 47 , and galect
There are great opportunities to use fire science-based models in fire service activates. However, it is necessary to applied and evaluated such models in a fire service context. This report summarises a project where the aim has been to investigate how fire dynamics is used and can be used to support fire service in preventative, investigative and operational activities. In general, there is room
Ba3Si6O12N2:Eu2+ and Ba3Si6O9N4:Eu2+ have strikingly similar atomistic structures, but the former is an efficient green phosphor at working temperature while the latter is a bluish-green phosphor whose luminescence decreases quite fast with temperature. Aiming at the understanding of such different behavior, we compute the quasiparticle electronic band structure of the two hosts, Ba3Si6O 12N2 and
Laser-wakefield accelerators (LWFAs) are high acceleration-gradient plasma-based particle accelerators capable of producing ultra-relativistic electron beams. Within the strong focusing fields of the wakefield, accelerated electrons undergo betatron oscillations, emitting a bright pulse of X-rays with a micrometer-scale source size that may be used for imaging applications. Non-destructive X-ray p
Background: Intracerebral hemorrhage (ICH) is the most serious adverse effect of treatment with oral anticoagulants. Prognostic data after ICH associated with non-vitamin K antagonist oral anticoagulants (NOAC) compared to vitamin K antagonists (VKA) are sparse. We compared 90-day survival and functional outcome following NOAC-ICH versus VKA-ICH using data from the Swedish Stroke Register (Riksstr
An integral equation-based numerical method for scattering from multi-dielectric cylinders is presented. Electromagnetic fields are represented via layer potentials in terms of surface densities with physical interpretations. The existence of null-field representations then adds superior flexibility to the modeling. Local representations are used for fast field evaluation at points away from their
Software reliability is a frequently used term, but very seldom the reliability is under control during a software development project. This paper presents a method, Statistical Usage Testing (SUT), which gives the possibility to estimate and predict, and hence control the software reliability. SUT is the reliability certification method described as a part of Cleanroom software engineering. The m
Exhaustive, automatic testing of dataflow (esp. mapreduce) programs has emerged as an important challenge. Past work demonstrated effective ways to generate small example data sets that exercise operators in the Pig platform, used to generate Hadoop map-reduce programs. Although such prior techniques attempt to cover all cases of operator use, in practice they often fail. Our SEDGE system addresse
Objectives: Iron deficiency anemia in childhood is a serious public health problem worldwide. Reticulocyte hemoglobin content (Ret-He) is a novel biomarker of iron deficiency adopted for adults but there is a lack of reference intervals for Ret-He in infants. The aim of this study was to provide data from healthy infants. Methods: Swedish infants (n = 456), born at term after normal pregnancies we
