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The modus operandi of most asset managers is to promise clients an annual risk target, where risk is measured by realized standard deviation of portfolio returns. Moreover, Markowitz (1952) portfolio selection requires an estimate of the covariance matrix of the returns of the financial instruments under consideration. To address both these problems, we develop a data-driven method for covariance
An important component of air disc brakes for heavy-duty vehicles is an adjusting mechanism, abbreviated 'adjuster', that regulates the clearance between the brake pads and the brake disc. The clearance is important to control as it affects the brake capacity. Normally, adjusters operate to decrease the clearance to compensate for wear of the brake pads. Recently, Haldex Brake Products AB
X-ray free-electron lasers (XFELs) open a new era of X-ray based research by generating extremely intense X-ray flashes. To further improve the spectrum brightness, a self-seeding FEL scheme has been developed and demonstrated experimentally. As the next step, new-generation FELs with high repetition rates are being designed, built and commissioned around the world. A high repetition rate would si
The generalized sparse iterative covariance-based estimation ( $q$ -SPICE) algorithm was recently introduced for scanning radar applications, resulting in substantial improvements in the angular resolution and quality of the processed images. Regrettably, the computational complexity and storage cost are high and quickly increase with growing data size, limiting the applicability of the estimator.
Aim: Bumetanide, a diuretic agent, that reduces intracellular chloride—thereby reinforcing GABAergic inhibition—has been reported to improve core symptoms of autism in children. Given the positive results reported from French trials of bumetanide in children with autism, we decided to evaluate its effects in a small-scale pilot study, in advance of a larger randomised controlled study (RCT). Metho
Background: Autonomous systems have received considerable attention from academia and are adopted by various industrial domains, such as automotive, avionics, etc. As many of them are considered safety-critical, testing is indispensable to verify their reliability and safety. However, there is no common standard for testing autonomous systems efficiently and effectively. Thus new approaches for te
In amyloid light chain (AL) amyloidosis, amyloid fibrils derived from immunoglobulin light chain are deposited in many organs, interfering with their function. The etiology of AL amyloidosis is poorly understood. Summary data from genome-wide association studies (GWASs) of multiple phenotypes can be exploited by Mendelian randomization (MR) methodology to search for factors influencingALamyloidosi
Tetraploidy constitutes a genomically metastable state that drives oncogenesis by leading aneuploidy. Tetraploid sub-population is frequently found in pre-neoplastic lesions. This particular population is relatively more resistant against DNA damaging agents and in consequence, it is important to selectively target tetraploid cancer cells. Here, we listed all the studies that targeted preferential
In this thesis we study functionals of the type \( \mathcal{K}_{f,A,\b}(\x)= \mathcal{Q}(f)(\x) + \|A\x - \b \| ^2 \), where \(A\) is a linear map, \(\b\) a measurements vector and \( \mathcal{Q} \) is a functional transform called \emph{quadratic envelope}; this object is a very close relative of the \emph{Lasry-Lions envelope} and its use is meant to regularize the functionals \(f\). Carlsson a
The increase in the scale of LHC computing during Run 3 and Run 4 (HL-LHC) will certainly require radical changes to the computing models and the data processing of the LHC experiments. The working group established by WLCG and the HEP Software Foundation to investigate all aspects of the cost of computing and how to optimise them has continued producing results and improving our understanding of
This thesis investigated the modeling and control problems in the context of the flex-fuel compression-ignition (CI) engine and fuel cell, which shows great potential in the transition from fossil fuel to renewable energy sources.The modeling parts included the flex-fuel engine combustion process and intake system, and the system scale fuel cell model.The flex-fuel engine gas system models describ
To be able to exploit the anticipated interaction rate of 50 kHz in Pb-Pb collisions during run 3 of the LHC (beyond 2019), the ALICE TPC will be upgraded to allow continuous readout. As this is not possible with the current Multi Wire Proportional Chamber (MWPC) based amplification, the readout will be replaced with Gas Electron Multiplier (GEM) readout chambers that can suppress ~ 99% of the ion
We derive the light-front wave function (LFWF) representation of the γ∗γ∗→ηc(1S),ηc(2S) transition form factor F(Q12,Q22) for two virtual photons in the initial state. For the LFWF, we use different models obtained from the solution of the Schrödinger equation for a variety of cc̄ potentials. We compare our results to the BABAR experimental data for the ηc(1S) transition form factor, for one real
Open-Source Software (OSS) is increasingly common in industry software and enables developers to build better applications, at a higher pace, and with better security. These advantages also come with the cost of including vulnerabilities through these third-party libraries. The largest publicly available database of easily machine-readable vulnerabilities is the National Vulnerability Database (NV
This chapter contains an overview of general policies regarding student housing in Sweden, a desription of market conditions for students renting a room or an apartment, and the legal framework regulating student housing in Sweden, including the rental contract.
Transformative justice has emerged in recent years as both a critical response to transitional justice and a new practice agenda for addressing structural and systemic violence. This chapter aims to set out a clear role for social scientific research in transformative justice. It argues in favour of a critical social science that assists practice by rendering transparent the structural and relatio
