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Protein kinase C (PKC) plays a prominent role in immune signaling, and the paradigms for isoform selective signaling are beginning to be elucidated. Real-time microscopy was combined with molecular and biochemical approaches to demonstrate a role for PKC-epsilon in Fcgamma receptor (FcgammaR)-dependent phagocytosis. RAW 264.7 macrophages were transfected with GFP-conjugated PKC isoforms, and GFP m

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Utgångspunkten för detta examensarbete har varit de utsatta och behövande barn vars föräldrar av någon anledning inte kan eller vill ta hand om dem. Den primära frågan har varit vilka möjligheter dessa barn har till ett tryggt och fungerade liv och om de alternativ som finns idag är tillräckliga. Nationell adoption infördes i Sverige i början på 1900-talet och användes relativt frekvent under de The primary basis of this dissertation is the vulnerable children of parents unable or unwilling to care for them. The crucial question has been what possibilities these children have to live safe and functioning lives and whether the options provided today are sufficient. National adoption was made possible in Sweden in the early 20th century and was frequently used during the first 40 years to