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Background and objective: Human studies of arterio-venous (AV) differences in drug concentrations and the consequences for pharmacokinetic modelling and concentration-effect relationships are very limited. We therefore investigated the intravenous and intra-arterial concentrations of alcohol (ethanol) during the absorption, distribution and elimination stages of alcohol metabolism in healthy men.
OBJECTIVE: To study the pharmacodynamics of amoxicillin/clavulanic acid against different strains of Haemophilus influenzae in an in vitro kinetic model. The concentrations used corresponded to human serum levels obtained after 875 mg amoxicillin/clavulanic acid given b.i.d., 500/125 mg amoxicillin/clavulanic acid given t.i.d. and those obtained with a pharmacokinetically enhanced formulation cont
Popular AbstractAvsikten med denna avhandling är att utveckla en teori om de försvårade villkor som män ur arbetarklassen och den lägre medelklassen upplevt i Ronneby sedan början av 1900-talet; om hur traditionen att snabbt komma ut i arbetslivet — som bland män i Ronneby i det närmaste har varit likvärdigt med att bli vuxen — ersatts av ett behov att senarelägga vuxenblivandet. Bakgrunden är attThe place is Ronneby, a smallish town in southern Sweden. My subjects are working class and lower middle class men in Ronneby, men who — since the beginning of the century — have encountered changing conditions for reaching adulthood. In this dissertation, I will analyse these changing and increasingly difficult conditions and try to explain how the tradition of starting to work early in life, and
Cross-sectional studies have associated obesity and other components of the so-called metabolic syndrome with low-grade inflammation. The temporal and causal relations of this association have not been fully explored. This study explored whether elevated levels of inflammation-sensitive plasma proteins (ISPs) (fibrinogen, orosomucoid, {alpha}1-antitrypsin, haptoglobin, and ceruloplasmin) are assoc
The dissertation outlines the ideas behind Torsten Fogelqvist's (1880-1941) ambitions as a publicist for Dagens Nyheter and as a public educator. The study also seeks to do justice to a forgotten, or at least not exhaustively analysed, discussion, during the first four decades of the last century, and deals with education, humanism, modernity, cultural heritage, the role of the press and anti-Nazi
The recognition that animals sense the world in a different way than we do has unlocked important lines of research in ecology and evolutionary biology. In practice, the subjective study of natural stimuli has been permitted by perceptual spaces, which are graphical models of how stimuli are perceived by a given animal. Because colour vision is arguably the best-known sensory modality in most anim
Background There is currently no standardized process for long-term follow-up care. As a result, management of post-stroke care varies greatly, and the needs of stroke survivors are not fully addressed. The Post Stroke Checklist was developed by the Global Stroke Community Advisory Panel as a means of standardizing long-term stroke care. Since its development, the Post Stroke Checklist has gained
Subsolidus phase relations have been determined for the BaO:TiO2:Ta2O5 system by X-ray diffraction analysis of ~100 specimens prepared in air at temperatures near but below the solidus (1275 °C to 1500 °C). For the BaO:Ta2O5 subsystem, the formation of all three polymorphs of BaTa2O6 (orthorhombic, tetragonal, and hexagonal) was confirmed. The present study found no stable phases forming between B
Purpose: To determine progression factors at the end of the Early Manifest Glaucoma Trial (EMGT) based on all EMGT patients and evaluate separately patients with higher and lower baseline intraocular pressure (IOP; median split). Design: Cohort of clinical trial participants. Participants: Patients with early open-angle glaucoma randomized to argon laser trabeculoplasty plus betaxolol (n = 129) or
Anesthesiology is the medical specialty dedicated to the relief of pain and care of the surgical patient before, during and after surgery. Most of the work in anesthesiology is routine patient care, but because patients are sick and surgical procedures may develop in unexpected ways, anesthesiology by its nature often involves medical crises. In recent years, two concepts have gained increasing i
Background: Thrombolysis is a common method in the treatment of lower extremity bypass graft occlusion. The purpose of this study was to investigate the results of thrombolytic therapy in the management of acute bypass graft occlusion and to identify risk factors for technical failure and amputation. Methods: All patients at two tertiary referral centers undergoing thrombolysis for acute graft occ
Relative to vascular plants, little is known about what factors control bryophyte communities or how they respond to successional and environmental changes. Bryophytes are abundant in boreal forests, thus changes in moss community composition and functional traits (for example, moisture and nutrient content; rates of photosynthesis and respiration) may have important consequences for ecosystem pro
Popular Abstract in Swedish Avhandlingen diskuterar Sociologins position i debatten kring artificiell intelligens, d.v.s sådan AI som kan skapa kunskap på egen hand. Det påpekas att sociologin behöver göra en åtskillnad mellan två sätt att skapa AI system: Symbolisk AI (eller Klassisk AI) och Distribuerad AI – DAI. Den sociologiska litteraturen visar en i stort kritisk attityd till symbolisk AI viThis dissertation is concerned with Sociology’s stance in the debate on Strong Artificial Intelligence, i.e. such AI that is able to shape new knowledge without human interference. There is a need for sociologists to realize the difference between two approaches to constructing AI systems: Symbolic AI (or Classic AI) and Distributed AI – DAI. Sociological literature shows a largely critical attitu
Att behandla tumörsjukdomar genom injektion av radioaktiva läkemedel är en behandlingsteknik kallad radionuklidterapi. Det radioaktiva läkemedlet består av en radioaktiv isotop, fäst på en målsökande bärarmolekyl, specifik för den vävnad vari man önskar att läkemedlet skall ansamlas. Då den radioaktiva isotopen sönderfaller sänds joniserande strålning ut; strålning med förmågan att jonisera molekyIntroduction: There is a need of reassessment of radiation absorbed dose specification in nuclear medicine, taking the non-uniformities in the distribution of radioactivity into account. This is especially important in radionuclide therapies where very high activities are administered and the radionuclides emit alpha particles, beta particles or low-energy electron and will require absorbed dose c
Återfall i brottslighet har under alla tider varit ett vanligt förekommande problem. Unga personer, dömda till sluten ungdomsvård, löper på grund av sin låga ålder extra stor risk att återfalla i brott. Svensk statistik uppvisar att så många som 60 procent återfaller i brottslighet redan inom ett års tid. Uppsatsens syfte är att utreda vilka orsaker som kan hänföras till återfall i brottslighet efRecidivism has always been a common problem. Young people, who are convicted and subjected to closed institutional youth care detention (LSU) runs, due to their young age, a particularly high risk to reoffend. Swedish criminal statistics shows that as many as 60 percent relapse into crime within a year. The purpose of this essay is to investigate the causes that can be attributed to relapse into c
Vid utformandet av en konstitution ställs alltid frågan om vilket förhållande som bör råda mellan politik och juridik. Det är upp till varje rättssystem att reglera vilket inflytande domstolen ska ha på utformningen av lagstiftningen. När det kommer till lagstiftning kan förhållandet mellan judiciell aktivism från domstolens sida och demokrati beskrivas som en dikotomi där två vitt skilda metoder When drafting a Constitution, the relationship between politics and law must always be determined. It is up to each legal system to regulate what influence the court should have on the formulation of legislation. When it comes to legislation, the relationship between judicial activism and democracy, can be described as a dichotomy in which two widely different methods stand for different ideals. T
Barn som är under 15 år kan inte straffas i svensk rätt enligt 1 kap. 6 § brottsbalken (BrB) och därmed kan de inte heller bli föremål för rättsväsendets åtgärder p.g.a. brott. När samhällsåtgärder därmed måste tas, ligger ansvaret på socialtjänsten. Begår ett barn ett brott kan det ändå utredas av polis och åklagare genom stöd av lagen om unga lagöverträdare (LUL), en s.k. 31 § LUL-utredning. SChildren under the age of 15 can commit crimes but they cannot be punished under Swedish law in accordance with Chapter 1, Section 6 of the Criminal Code and therefore they cannot be subject to a preliminary criminal investigation by a Prosecutor or the Police. Instead, when children have committed a crime other societal measures can be taken. The responsibility for the care for these children lie
Glycosaminoglycans (GAGs) are polysaccharides produced by essentially all mammalian cells. Due to their enormous structural diversity, they are involved in many biological processes both in health and disease, including all stages of tumor progression. GAGs are normally attached to a core protein as a part of a proteoglycan; however, GAG biosynthesis can be induced by compounds composed of a xylos
This presentation highlights results from a research study of ‘Music Week’; a one-week Swedish music project. The aim of the ‘Music Week’ project was to enable young people with physical impairments to take part in musical activities. Digitally-based musical settings were used in order to provide tools for performing and creating music. The main purpose of the present research study was to explore
Background: The relationship between dyslipidemia, inflammation and CV organ damage in type 2 diabetes mellitus (T2DM) is complex. Insulin resistance and inflammatory cytokines interleukins (ILs) increase plasma triglycerides (TG). ILs also up-regulate expression of matrix-metalloproteinases (MMPs) that, together with TG, decrease high density lipoprotein cholesterol (HDL) levels. High TG, low HDL
