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Background: Deep learning convolutional neural networks (CNN) may facilitate melanoma detection, but data comparing a CNN's diagnostic performance to larger groups of dermatologists are lacking.Methods: Google's Inception v4 CNN architecture was trained and validated using dermoscopic images and corresponding diagnoses. In a comparative cross-sectional reader study a 100-image test-set was used (l
This report summarizes a survey performed in eight countries on the status quo of daylight and electric lighting control systems. Feedback from more than 100 international experts (building / facility managers and planers) was evaluated. The aim of the survey was to identify the perception of the different possibilities of the current lighting control solutions and the expectations about the contr
Infections by pathogenic microorganisms remain one of the most serious concerns in several areas, particularly in hygienic applications. Antimicrobials have been used to combat these infections. Using small molecular antimicrobials as additives or coatings is an industrially adopted strategy. However, small antimicrobial agents always suffer from many drawbacks, such as leaching potential, toxicit
PURPOSE: The authors characterized the natural history of a retinoschisin gene knockout (Rs1h-KO) mouse model and evaluated the long-term effects of retinal rescue after AAV(2/2)-CMV-Rs1h gene delivery.METHODS: Full-field scotopic electroretinograms (ERGs) were recorded from 44 male hemizygous Rs1h-KO and 44 male wild-type (WT) C57BL/6J mice at six ages between 1 and 16 months. Retinal morphometry
Ciliary neurotrophic factor (CNTF) promotes photoreceptor survival but also suppresses electroretinogram (ERG) responses. This has caused concerns about whether CNTF is detrimental to the function of photoreceptors because it is considered to be a potential treatment for retinal degenerative disorders. Here we report that the suppression of ERG responses is attributable to negative regulation of t
The incorporation of water isotopologues into the hydrology of general circulation models (GCMs) facilitates the comparison between modeled and measured proxy data in paleoclimate archives. However, the variability and drivers of measured and modeled water isotopologues, as well as the diversity of their representation in different models, are not well constrained. Improving our understanding of t
Scour is an important cause of bridge failures. This article investigates the impact of climate change on bridge-pier scour in all 246 Swedish catchment areas. Although a few previous studies assessed the impact of climate change on bridge-pier scour in other countries, none of those studies identified the locations within a certain country where climate change is projected to have the highest imp
Human activities in coastal areas have intensified over the last 200 years, impacting also high-latitude regions such as the Baltic Sea. Benthic foraminifera, protists often with calcite shells (tests), are typically well preserved in marine sediments and known to record past bottom-water conditions. Morphological analyses of marine shells acquired by microcomputed tomography (µCT) have made signi
Acute and chronic lung diseases are a major cause of global mortality. While pharmacological approaches exist, no therapies are curative. The only option at end-stage disease is lung transplantation which is hampered by a chronic shortage of donor organs. Therefore, there is a high interest to develop alternative approaches to use regenerative medicine approaches to generate new lung tissue in the
Background:: Those who are seriously ill and facing death are often living with physical, emotional, social, and spiritual suffering. Teamwork is considered to be necessary to holistically meet the diverse needs of patients in palliative care. Reviews of studies regarding palliative care team outcomes have concluded that teams provide benefits, especially regarding pain and symptom management. Muc
Huntington’s disease (HD) is caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene. HD is an inherited progressive neurodegenerative disorder manifested by the wide array of motor dysfunctions, as well as non-motor symptoms. The latter include metabolic dysfunction and psychiatric deficits, such as depression and anxiety, are often observed in patients andanimal models of HD
Addressing sustainability concerns in supply chain operations can be a matter of long-term business survival for food retailers. However, regardless of whether it is perceived as a risk or market opportunity, acting across the value chain to address unsustainable production and consumption practices has been a constant challenge. This thesis investigated the sustainable supply chain management (SS
BACKGROUND: Lung transplantation is hindered by low donor lung utilization rates. Infectious complications are reasons to decline donor grafts due to fear of post-transplant primary graft dysfunction. Mesenchymal stem cells are a promising therapy currently investigated in treating lung injury. Full-term amniotic fluid-derived lung-specific mesenchymal stem cell treatment may regenerate damaged lu
Context:Bug reports created during software development and maintenance do not always describe deviations from a system’s valid behavior. Such invalid bug reports may consume significant resources and adversely affect the prioritization and resolution of valid bug reports. There is a need to identify preventive actions to reduce the inflow of invalid bug reports. Existing research has shown that m
Background: Umbilical cord clamping strategies at preterm birth have the potential to affect important health outcomes. The aim of this study was to compare the effectiveness of deferred cord clamping, umbilical cord milking, and immediate cord clamping in reducing neonatal mortality and morbidity at preterm birth. Methods: We conducted a systematic review and individual participant data meta-anal
The early career professionals in the field of Cardiovascular Magnetic Resonance (CMR) face unique challenges and hurdles while establishing their careers in the field. The Society for Cardiovascular Magnetic Resonance (SCMR) has expanded the role of the early career section within the society to foster the careers of future CMR leaders. This paper aims to describe the obstacles and available oppo
The medial temporal lobe (MTL) is connected to the rest of the brain through two main networks: the anterior-temporal (AT) and the posterior-medial (PM) systems. Given the crucial role of the MTL and networks in the physiopathology of Alzheimer's disease (AD), the present study aimed at (1) investigating whether MTL atrophy propagates specifically within the AT and PM networks, and (2) evaluating
Rising demand for food production poses a major threat to biodiversity by placing competing pressures on land. Diversified farming systems are one widely promoted nature-based solution to this challenge, which aim to integrate biodiversity-based ecosystem services into agricultural production. The underlying theory behind this approach is that diverse communities enhance ecosystem service provisio
Background: The European Cooperation in Science and Technology (COST) Action 21122, PROmoting GeRiAtric Medicine in countries where it is still eMergING (PROGRAMMING) developed an online open survey to assess the educational interests and needs of health care professionals and final-year medical students across participating countries. This survey aims to establish a current baseline for developin
