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Sveriges utveckling i form av ett mer digitaliserat och elektrifierat samhälle medför en högre belastning på elnätet. Samtidigt är elnätet inte dimensionerad för denna belastning. Nätets kapacitet är direkt kopplat till effektuttag och för att jämna ut och minska höga effekttoppar i nätet beslutades det därför att införa effektavgifter senast den 1 januari 2027. Under tiden arbetet skrevs beslutadSweden’s development towards a more digitalized and electrified society is increasing the load on the electricity grid. At the same time, the grid is not dimensioned for this level of demand. The grid capacity is directly linked to power demand, and to reduce and smooth out high-power peaks, it was decided that demand-based electricity tariffs would be introduced no later than January 1, 2027. Dur

The industrial sector of Sweden used 136 TWh of energy 2022 out of which the agricultural sector used 6.09 TWh. The goal of the country is to become 50% more energy efficient by 2030 compared to 2005. Furthermore, Sweden’s long-term target is to achieve net zero greenhouse gas emissions by 2045. From 2005-2022 the total energy use of the agricultural sector has been reduced by 16% but previous stu

Understanding how cancer cells regulate endocytosis during the cell cycle could lead us to capitalize this event pharmacologically. Although certain endocytosis pathways are attenuated during mitosis, the endocytosis shift and regulation during the cell cycle have not been well clarified. The conventional concept of glucose-regulated proteins (GRPs) as protein folding chaperones was updated by dis

The therapeutic potential of glial cell line-derived neurotrophic factor ( GDNF) for Parkinson's disease is likely to depend on sustained delivery of the appropriate amount to the target areas. Recombinant adeno-associated viral vectors ( rAAVs) expressing GDNF may be a suitable delivery system for this purpose. The aim of this study was to define a sustained level of GDNF that does not affect the

Astrocytes are, as normal constituents of the brain, promising vehicles for ex vivo gene delivery to the central nervous system. In the present study, we have used a lentiviral vector encoding glial cell line-derived neurotrophic factor (GDNF) to transduce rat-derived primary astrocytes, in order to evaluate their potential for long-term transgene expression in vivo and neuroprotection in a rat mo

https://www.lthin.lth.se/en/professional-support/administration/purchases-procurement-and-contracts/purchase-av-equipment - 2026-06-19

Inherited retinal degeneration (RD) is a devastating and currently untreatable neurodegenerative condition that leads to loss of photoreceptor cells and blindness. The vast genetic heterogeneity of RD, the lack of “druggable” targets, and the access-limiting blood–retinal barrier (BRB) present major hurdles toward effective therapy development. Here, we address these challenges (i) by targeting cG

Glial cell line-derived neurotrophic factor (GDNF) has shown potential as a treatment for Parkinson's disease. Recombinant adeno-associated viral vectors expressing the GDNF protein (rAAV-GDNF) have been used in rodent models of Parkinson's disease to promote functional regeneration after 6-OHDA lesions of the nigrostriatal system. The goal of the present study was to assess the anatomical and fun