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Atherosclerosis is a chronic inflammatory disease of medium and large vessels of the body which is mainly characterized by the formation of lipid rich plaques within the arterial tissue. It is the most common cause of cardiovascular disease leading to clinical manifestations of coronary artery and cerebrovascular disease. Immune responses targeting modified low density lipoprotein (LDL) play an im
Streptococcus pyogenes infects over 700 million people worldwide annually. Immune evasion strategies employed by the bacteria include binding of the complement inhibitors, C4b-binding protein (C4BP) and Factor H in a human-specific manner. We recently showed that human IgG increased C4BP binding to the bacterial surface, which promoted streptococcal immune evasion and increased mortality in mice.
Pyranose 2-oxidase (P20x) has several proposed biotechnological applications such as a bio-component in biofuel cells or for carbohydrate transformations. To improve some of the catalytic properties of P20x from Trametes multicolor, we selected a semi-rational approach of enzyme engineering, saturation mutagenesis of active-site residues and subsequent screening of mutant libraries for improved ac
This dissertation deals with the effects of coherence and correlations on transport through nanostructures. Simulations are mainly performed using the second order von Neumann approach, a method capable of dealing with these effects in the presence of higher order tunneling. We see that such effects can result in various kinds of current suppression as well as efficient thermoelectric devices. Fu
This review compares the methodology of published clinical studies investigating the extended-half-life (EHL) factor VIII (FVIII) products, rFVIIIFc (efmoroctocog alfa, Elocta®/Eloctate®), BAY 94-9027 (damoctocog alfa pegol, Jivi®), BAX 855 (rurioctocog alfa pegol, Adynovate®) and N8-GP (turoctocog alfa pegol, Esperoct®) including the phase 2/3 studies, A-LONG (NCT01181128), PROTECT VIII (NCT01580
BackgroundGeneral practitioners (GPs) do not see men with localised urinary tract infection (UTI) very often which limits their possibility of developing expertise in the area. To gain knowledge of male patients’ experiences and perspectives on localised UTIs, qualitative research is needed.AimTo explore expectations, experiences and symptoms in men with localised urinary tract infection in primar
University teachers’ engagement in teaching is a crucial aspect for the quality of student learning. In this article, we explore where such engagement comes from. We use a sociocultural perspective to investigate how teachers’ colleagues and leaders, in what we call academic microcultures, influence such engagement. A microculture can be a working group such as a teaching team, an educational prog
The article is based upon empirical data from a Swedish three-year research project entitled “Communicative Organizations”, investigating the value of communication for organizations. The project is involves eleven organizations. Based upon empirical data from a quantitative survey (n = 6486) the perceived value of strategic communication and communication professionals, mainly among managers and
Compensational voting refers to when voters cast a vote for a more extreme party than they prefer, in order to push policies closer to an ideal point. This article develops the idea of compensational voting in regard to pre-electoral coalition signals and polling trends. The argument is that a significant share of voters consider the relative strength of the parties in their preferred pre-electora
