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Mononuclear iron(iv)-oxo, iron(iv)-imido and iron(iv)-nitrido complexes are common catalytic cycle intermediates in enzymes, where the metal is typically linked to the protein through cysteinate or histidine sidechains. Enzymatic high-valent iron(iv)-imido and -nitrido intermediates have never been trapped and characterized; hence, there is uncertainty regarding their structure and function. Using
In this short podcast, we define ageism and describe how it is quietly pervasive in our everyday lives. We discuss the negative impacts of ageism, provide examples, and identify ways to combat ageism. Target audience: high school/secondary school students. Music and mixing by Sean Mac.En este breve podcast, hablamos sobre el edadismo o discriminación por edad y describimos cómo está silenciosament
The relationship between requirements engineering and testing has been a key interest throughout my research career. It cannot be that requirements engineers are from Omicron Persei 7 and testers from Omicron Persei 9—we all live on the same planet. I’m happy to co-author this column with a former collaborator from a test automation EU project, now a manager at Ericsson. With this issue’s focus on
Life’s Essential 8 (LE8) is a score that includes modifiable risk factors for cardiovascular disease. Four health behaviors (diet, physical activity, nicotine exposure and sleep health) and four health factors (non-HDL cholesterol, blood glucose, blood pressure and body mass index) are included. These modifiable risk factors promote inflammation, and inflammation is one of the biological mechanism
Structural maintenance of chromosome (SMC) complexes organize and regulate genomes via DNA loop extrusion. During this process, the complexes increase the loop size by reeling in DNA from one or both sides of the loop. The factors governing this symmetry remain unclear. Here, we combine single-molecule analysis and molecular dynamic simulations to investigate the symmetry of loop extrusion of vari
This paper argues that conventional blame practices fall short of capturing the complexity of moral experiences, neglecting power dynamics and discriminatory social practices. It is evident that robots, embodying roles linked to specific social groups, pose a risk of reinforcing stereotypes of how these groups behave or should behave, so they set a normative and descriptive standard. In addition,
A drop of systemic blood pressure (BP) occurring shortly after individuals move from supine or seated position to upright posture with subsequent prompt spontaneous resolution is a common physiological occurrence in humans. If the induced hypotension is severe, lightheadedness or postural instability leading to falls and injury may occur. By consensus, a transient systolic BP drop >40 mmHg within
OBJECTIVE: Insulin-like growth factor 1 receptor (IGF1R) acts at the crossroad between immunity and cancer, being an attractive therapeutic target in these areas. IGF1R is broadly expressed by antigen-presenting cells (APC). Using mice immunised with the methylated albumin from bovine serum (BSA-immunised mice) and human CD14 + APCs, we investigated the role that IGF1R plays during adaptive immune
INTRODUCTION: Neuroinflammation is a major contributor to the progression of frontotemporal dementia (FTD). Galectin-3 (Gal-3), a microglial activation regulator, holds promise as a therapeutic target and potential biomarker. Our study aimed to investigate Gal-3 levels in patients with FTD and assess its diagnostic potential. METHODS: We examined Gal-3 levels in brain, serum, and cerebrospinal flu
This paper sets out to investigate what is “conceptual performing arts” and define how one could begin to fill out the lack of a definition. The paper has been peerreviewed within the context of "Högskolepedagogisk utbildning".
A strong and prevailing innovation imperative is sweeping across the public sector and despite a growing literature on public sector innovation (PSI), the actors driving these processes tend to end up in the background of analysis. Based in an analytical framework of narrative theory and organization studies, and the efforts to introduce Social Impact Bonds (SIB) in Sweden as empirical case, the a
