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Reduced fibrinolytic capacity due to increased plasminogen activator inhibitor-1 (PAI-1) activity in plasma is a common finding in patients with coronary heart disease or venous thromboembolism, although its clinical significance is debated. Recently, a dimorphism in the PAI-1 promoter (4G-5G) has been reported and homozygosity for the 4G allele is associated with increased transcription and highe
All-polymer blends are promising materials for organic electronics. Their performance critically depends on the quality of mixing of the electron donor and acceptor polymers and on the local chain organization. We investigated spatially resolved photoluminescence properties of as-prepared and annealed blends of poly[2,3-bis(3-octyloxyphenyl)quinoxaline-5,8-diyl-alt-thiophene-2,5-diyl] (TQ1) and po
The currently available data on the distribution of C2 fracture subtypes is sparse. This study was designed to identify the proportions of the second cervical vertebra (C2) fracture subtypes and to present age and gender specific incidences of subgroups. A dataset of all patients treated between 2002 and 2014 for C2 fractures was extracted from the regional hospital information system. C2 fracture
We recently reported that differential gene expression and DNA methylation profiles in blood leukocytes of apparently healthy smokers predicts with remarkable efficiency diseases and conditions known to be causally associated with smoking, suggesting that blood-based omic profiling of human populations may be useful for linking environmental exposures to potential health effects. Here we report on
Scope: Lingonberries have been shown to reduce the detrimental effects of high-fat diet (HFD) on weight gain, plasma glucose, and inflammation. However, the extent of effects was recently shown to vary between different batches of berries. Here, we examine the metabolic response to two independent batches of lingonberries. Methods and results: Alterations in the phenotype and circulating metabolom
It has been hypothesized that low frequency (1-5% minor allele frequency (MAF)) and rare (<1% MAF) variants with large effect sizes may contribute to the missing heritability in complex traits. Here, we report an association analysis of lipid traits (total cholesterol, LDL-cholesterol, HDL-cholesterol triglycerides) in up to 27 312 individuals with a comprehensive set of low frequency coding varia
This study explored the ability of blind and sighted listeners to detect reflections, "echoes", of burst trains or continuous noise. Echo detection was compared by presenting 5 ms bursts, rates from 1 to 64 bursts, with a continuous white noise, all during 500 ms. Sounds were recorded in an ordinary room through an artificial binaural head, the loudspeaker 1 m behind it. The reflecting object was
A current focus of ecosystem services (ES) implementation is on the municipal level of government where international and national legislation and policies have to be translated into practice. Given this focus, an understanding of perceptions within municipalities of the ES concept is crucial to support the implementation process. Against this background, this paper examines the perceptions of Swe
Purpose - The purpose of this paper is to carry out a numerical investigation to study forced convection for a tube with fins on the inner and outer surfaces with water as the base fluid and adding particles of CuO to have a nanofluid. Design/methodology/approach - Three geometries are designed by using Solid Works and the number of inside fins is 20 with height 6 mm and thickness 1mm. The number
Several genetic studies have demonstrated an association between mutations in glucocerebrosidase (GBA), originally implicated in Gaucher's disease, and an increased risk of Parkinson's disease (PD). We have investigated the possible involvement of genetic GBA variations in PD in the Swedish population. Three GBA variants, E326K, N370S, and L444P were screened in the largest Swedish Parkinson cohor
We study a design framework for robust, independently verifiable, and workload-balanced distributed algorithms working on a common input. The framework builds on recent noninteractive Merlin--Arthur proofs of batch evaluation of Williams~[31st IEEE Colloquium on Computational Complexity (CCC'16, May 29-June 1, 2016, Tokyo), to appear] with the basic observation that Merlin's magic is not needed fo
Atmospheric nitrogen (N) dry deposition is an important component in total N deposition. However, uncertainty exists in the assessment of global dry deposition. Here, we develop empirical models for estimating ground N concentrations using NO 2 satellite measurements from the Ozone Monitoring Instrument (OMI) and ground measurements from 555 monitoring sites. Global patterns and trends in the flux
Anaplastic thyroid cancer (ATC) is one of the most malignant tumors, with a median survival of only a few months. The tumorigenic processes of this disease have not yet been completely unraveled. Here, we report an mRNA expression and DNA methylation analysis of fourteen primary ATCs. ATCs clustered separately from normal thyroid tissue in unsupervised analyses, both by RNA expression and by DNA m
The extent of today's land degradation and desertification in the arid, semi-arid. and sub humid regions of China is a serious threat to the social and economic development in these areas. A national programme for monitoring and classification of drylands has been implemented by the Chinese Academy of Science. Areas are classified into degrees of desertification on the basis of vegetation cove
Objective: To examine and compare the adult outcome in a representative sample of hospitalized adolescent-onset psychoses including occupational and social aspects. Method: A total of 81 patients with a first episode of early-onset psychosis (before age 19 years) presenting to the University Hospital of Lund, Sweden, between 1982 and 1993 were followed up an average of 10.5 years (range 5.1-18.2)
The major aim of the study was to investigate whether differences concerning acceptance of dental treatment and amnesia after rectal sedation with midazolam can be explained by temperament traits in the child. Fifty children (1.5- 4.0 years), consecutively referred for dental extractions because of dental trauma or caries, were sedated with midazolam 0.3 mg kg(1) rectally. Level of sedation (state
