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Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model 5 9 2 | N A T U R E | V O L 5 4 8 | 3 1 au g u s t 2 0 1 7 Letter doi:10.1038/nature23664 Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model Tetsuhiro Kikuchi1, Asuka Morizane1, Daisuke Doi1, Hiroaki Magotani1, Hirotaka Onoe2, Takuya Hayashi2, Hiroshi Mizuma2, Sayuki

https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/publication_in_nature_0.pdf - 2026-07-11

Inhaled corticosteroid (ICS) therapy is central to the long-term management of asthma and is extensively used in the management of chronic obstructive pulmonary disease (COPD). While administration via inhalation limits systemic exposure compared with oral or injected corticosteroids and, therefore, the risk of systemic corticosteroid-related adverse effects, concerns over the long-term safety of

The thesis concerns glycosyl transfer with use of b-glycosidases, most of them from hyperthermophilic organisms. Both optimisation of the reaction conditions and protein engineering in terms of site-directed mutagenesis were used to improve b-glycosidase-catalysed reactions. The first part of the work deals with conversion of lactose into valuable products such as galacto-oligosaccharides (GOS) an

The purpose of this thesis is to investigate whether a new rule of customary international law has evolved that allows for an exception to the Head of State immunity regarding the perpetration of international crimes. In the legal literature and in codification attempts the view has been expressed that this new rule already exists. This thesis investigates whether this is a correct interpretation

BACKGROUND: The Nordic countries have commonalities in gender equality, economy, welfare, and health care, but differ in culture and lifestyle, which might create country-wise health differences. This study compared life expectancy, disease burden, and risk factors in the Nordic region.METHODS: Life expectancy in years and age-standardised rates of overall, cause-specific, and risk factor-specific

IntroductionConsidering that on average in developed countries we spend about 65% of our time in private homes, understanding the exposures in homes is of outmost importance. Aerosol concentrations indoors come from indoor sources, infiltrate from outdoors and can be formed from precursors both of indoor and outdoor origin. Several characteristics and processes influence the properties of aerosols

The overall aims of this thesis were to investigate the effects of an aerobic exercise program and the impact of migraine and co-existing TTH and NP in persons with these combined conditions. This thesis is based on four studies.In study I, a new questionnaire, Impact of Migraine, TTH and NP (Impact M-TTH-NP), was developed. This questionnaire covered pain, triggers, psychosocial,socioeconomic and

Importance Perforated colonic diverticulitis usually requires surgical resection, with significant morbidity. Short-term results from randomized clinical trials have indicated that laparoscopic lavage is a feasible alternative to resection. However, it appears that no long-term results are available. Objective To compare long-term (5-year) outcomes of laparoscopic peritoneal lavage and primary

Context. Parallaxes for 331 classical Cepheids, 31 Type II Cepheids, and 364 RR Lyrae stars in common between Gaia and the Hipparcos and Tycho-2 catalogues are published in Gaia Data Release 1 (DR1) as part of the Tycho-Gaia Astrometric Solution (TGAS). Aims. In order to test these first parallax measurements of the primary standard candles of the cosmological distance ladder, which involve astrom

Syftet med studien är att undersöka den förbättrade upptagningen av det radioaktiva spåret Technetium-99m-DTPA (99mTc-DTPA) i råtta Muskelvävnad i Fischer 344 råttor efter applicerade elektriska pulser av olikafältstyrka och pulslängd,Metoder: 99mTc-DTPA (totalt 150 MBq) administrerades intramuskulärt (i.m.) vid axelnsom en bolus i flera fraktioner om 50 l var och en i intervaller på 1 minut. Bil

Microplastics (MPs) in biosolids used as soil amendments are of growing concern. The purpose of this study was to improve the characterization of MPs in complex biosolid matrices by optimizing sample preparation for morphological and chemical analyses with different spectroscopic techniques. We compared extraction procedures involving Fenton oxidation (F), Fenton plus sodium dodecyl sulfate (SDS),

Age is a critical determinant of arterial disease, including aneurysm formation. Here, to understand the impact of aging on the arterial transcriptome, we leveraged RNA-sequencing data to define transcripts that change with advancing age in human arteries. Among the most repressed transcripts in aged individuals were those that are relevant for actomyosin structure and organization, including both

This chapter argues for the continued importance of studying the intertwining of Enlightenment and confessional culture in order to increase our understanding of how the Enlightenment took shape in the Nordic countries during the long eighteenth century. Proceeding from a careful evaluation of current scholarship, it provides an overview of political, cultural and socio-economic tendencies in the

PURPOSE: Absent lymph flow and chronic inflammationleads to excess subcutaneous adipose tissue deposition.Chronic non-pitting lymphedema does not respond to conservativetreatment or microsurgical procedures becausethey do not target the adipose tissue. Removing the adiposetissue using suction assisted lipectomy (SAL) seems thus tobe a logic treatment strategy.METHODS: Arms: 190 women, mean±SEM age

Background The World Health Organisation (WHO) 2013 diagnostic criteria for gestational diabetes mellitus (GDM) has been criticised due to the limited evidence of benefits on pregnancy outcomes in different populations when switching from previously higher glycemic thresholds to the lower WHO-2013 diagnostic criteria. The aim of this study was to determine whether the switch from previous Swedish

Background: Irritable bowel syndrome (IBS) is a common disease with unknown etiology. Poor dietary intake with nutritional deficiency and overweight have been described to increase the risk of IBS. The aim of the present study was to compare weight and circulating levels of micronutrients in IBS compared with healthy controls. Design: Cross-sectional study. Methods: Patients diagnosed with IBS and

This article uses a new database of 1,891 probate inventories from rural southern Sweden to investigate the development of rural households’ productive capacity from the late 1600s to the 1860s. Both labourers and farmers improved their material living standards – as measured by the contents of probate inventories – but the labouring households’ ownership of means of production decreased over timeThis article uses a new database of 1,891 probate inventories from rural southern Sweden to investigate the development of rural households’ productive capacity from the late 1600s to the 1860s. Both labourers and farmers improved their material living standards – as measured by the contents of probate inventories – but the labouring households’ ownership of means of production decreased over time

Importance: Novel plasma biomarkers, especially phosphorylated tau (p-tau), can detect brain tau aggregates in Alzheimer disease. Objective: To determine which plasma biomarker combinations can accurately detect tau pathological brain changes in Down syndrome (DS). Design, Setting, and Participants: The cross-sectional, multicenter Alzheimer's Biomarker Consortium-Down Syndrome study included adul

On February 23, 2022, The EU Commission published its Proposal for a Directive of the European Parliament and of the Council on Corporate Sustainability Due Diligence and amending Directive (EU) 2019/1937 (“CSDDD” or “the Proposal”). The purpose of the Proposal, to further the “Union’s transition to a climate-neutral and green economy in line with the European Green Deal and in delivering on the U