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Introduction Aggrecanase cleavage at the (392)Glu-(393)Ala bond in the interglobular domain (IGD) of aggrecan, releasing N-terminal (393)ARGS fragments, is an early key event in arthritis and joint injuries. Here, we use a quantitative immunoassay of aggrecan ARGS neoepitope fragments in human synovial fluid to determine if this cleavage-site specific method better identifies joint pathology than

Aims Experimental studies suggest that the autonomic nervous system modulates atrial refractoriness and conduction velocity in atrial. fibrillation (AF). These modulatory effects are, however, difficult to assess in the clinical setting. This study sought to non-invasively characterize in patients with persistent AF, the influence of autonomic modulation induced by exercise on atrial fibrillatory

Objective: (1) To evaluate constraint-induced movement therapy for chronic stroke patients modified into group practice to limit the demand on therapist resources. (2) To explore whether extended mitt use alone may enhance outcome. Design: A combined case-control and randomized controlled study with pre- and post-treatment measures by blinded observers. Setting: A university hospital rehabilitatio

The association of L-type Ca(2+) channels to the secretory granules and its functional significance to secretion was investigated in mouse pancreatic B cells. Nonstationary fluctuation analysis showed that the B cell is equipped with <500 alpha1(C) L-type Ca(2+) channels, corresponding to a Ca(2+) channel density of 0.9 channels per microm(2). Analysis of the kinetics of exocytosis during voltage-

Background: Environmental and genetic factors predispose an individual to the development of Graves' disease (GD). In an expression study of intraorbital tissue, adipocyte-related immediate early genes (IEGs) and immunomodulatory genes were found to be overexpressed in patients with Graves' ophthalmopathy (GO). We hypothesized that genetic variations in these genes could be associated with GD and/

The purpose of this master’s thesis is to provide a contribution to the research body regarding consumer returns, particularly within the online fashion retail industry. A quantitative data analysis approach is chosen and two main methods are used: data study that aims to identify patterns and interesting relationships in the data, and a simulation study that uses real input data to attempt to ide

Public procurement and the purchasing of goods, services and works comprises about 14% of the European gross domestic product (GDP). Procurement initiatives, guidance and tools therefore can have significant influence to leverage demands for more sustainable and circular products and services. This study explores the current circular public procurement (CPP) landscape, looking at barriers and oppo

Disaster management is a field, where any kind of information is essential for planning and rescue operations. The availability of real-time data on a portable device, such as a smartphone, can be very useful for emergency workers, during rescue operations and citizens as well. Augmented mobile reality is a system where the users can see overlayed data and visuals in the real environment through t

Most migratory bird species divide their migration in stages of flight and stopovers. They use these stopovers to refuel the energy reserves needed to face their long migration journeys. These stopovers are an important element to determine the overall migration speed. Time spent on migration and arrival date to the wintering grounds have been demonstrated to have a large effects the following bre

Kolloider är partiklar i storleksordningen nm till μm. De är viktiga i biologiska system, där exempelvis proteiner är en typ av kolloid. Att studera kolloider ger oss därför insikt i hur till exempel proteiner byggs upp och interagerar. I detta fall försökte vi tillverka kolloidala molekyler, alltså kolloider som interagerar med varandra genom ett specifikt antal bindningar i väl definierade positThe ability of thermoresponsive, amine-functionalized microgel particles to take part in microgelmicrogel inter-cross-linking has previously been reported in the literature, in connection to applications such as for example the formation of stimuli-responsive colloidal gels and colloidosomes [1]. This thesis deals with the synthesis of such thermoresponsive, cross-linkable microgels and their subs

Under 1990-talet och fram till 2007 var det vanligt förekommande att byggnader uppfördes med en så kallad enstegstätad fasadkonstruktion. Det byggdes omkring 15 000 – 30 000 bostadshus med denna konstruktion, vilka omfattar 110 000 – 160 000 bostäder. Ett stort antal av byggnaderna uppförda med den aktuella fasadkonstruktionen fick fukt- och mögelskador redan efter några år. År 2007 uppmärksammaDuring the 1990s and up until 2007, it was common that buildings were erected with a construction method known as External Thermal Insulation Composite System Walls. Around 15 000 – 30 000 residential buildings were built using this method and these constitute 110 000 – 160 000 residences. A large number of the buildings constructed with the this method got damp and mold damage after only a few y

Generellt sett har cyklande alltid väjningsplikt när de korsar en körbana från en cykelbana. Syftet med detta projekt är att jämföra effekten av omvänd väjningsplikt, det vill säga då motorfordon har skyldighet att väja för cyklande, med traditionell cykelöverfart där cyklande ska ge företräde. Avsikten är att bedöma framkomligheten för cyklande vid cykelöverfarter med olika väjningsreglering och Generally cyclists are obliged to give way when crossing a roadway from a bicycle path. The purpose of this thesis is to compare the effect of reverse right of way, that is when motor vehicles have duty to give cyclists way, with traditional crossing were cyclists are obliged to yield. The intention is to assess the level of service of cyclist on bicycle crossings with different yielding regulatio

Influencers i sig själva utgör personliga varumärken, inbegripet personnamn, image, koncept på sociala medier, utseende m.m. Vidare innebär yrket ofta att influencers mot ersättning marknadsför näringsidkares produkter eller tjänster på sina sociala medier. Näringsidkare använder sig således av influencers varumärke samt den redan etablerade relationen som finns mellan influencers och deras följarInfluencers as individuals can be viewed as personal trademarks, which includes name, image, layout on social media, appearance etc. Furthermore, the profession often includes that influencers for remuneration markets companies’ products or services on their social media channels. By doing so, the companies utilize the already established relationship between the influencer and his/her followers.

Introduction: This study evaluated lipid identification using mass spectrometry. Background: Three main modes of acquisition are used in mass spectrometry of lipids; data-independent acquisition (DIA), data-dependent acquisition (DDA) and targeted acquisition. DIA is the most including one, yielding a complete but complex data set, while targeted is the least including one, basing acquisition on

PCDD/Fs and dl-PCBs, or more commonly referred to as dioxin and dioxin like substances are compounds present in our surrounding environment. As some congeners of these have been shown to be toxic, they are regulated under the Stockholm Convention. As dioxins are persistent in biota and have lipophilic properties they are seen accumulating in lipid rich fish in the Baltic, one of the affected speci

Klimatförändringarna, energikrisen och en ökande efterfrågan på el har uppmärksammat behovet av en hållbar omställning av energisystemet. Havsbaserad vindkraft spelar en viktig roll i denna omställning och förväntas expandera kraftigt globalt, i EU och i Sverige. Samtidigt möter projekt stort lokalt motstånd. Trots att svenskar generellt visar högt stöd för vindkraft så har en majoritet av de senaClimate change, the energy crisis of 2022-2023, and estimations of future electricity demands have stressed the necessity for a rapid transition of the energy system. Offshore wind energy plays an important role in this transition, and is expected to expand considerably on a global level, in the EU and in Sweden. While Swedes show high support of wind energy, a majority of recent projects have bee

Background: Principles of brain plasticity is used in the treatment of patients with functional limitations to improve sensorimotor function. Training is included in the treatment of knee injury to improve both patient-reported function and sensorimotor function. However, impairment in sensorimotor function often persists despite training. Therefore, it was suggested that training programs need to

Background: Pancreatic cancer and other pancreaticobiliary type periampullary adenocarcinomas have a dismal prognosis even after resection and neoadjuvant chemotherapy. Intestinal type periampullary adenocarcinomas generally have a better prognosis, but little is known on optimal neoadjuvant and adjuvant treatment. New prognostic and treatment predictive biomarkers are needed for improved treatmen

Objectives To study regional cerebral blood perfusion with power Doppler ultrasound (PDU) imaging in appropriate-for-gestational age (AGA) fetuses and those with intrauterine growth restriction (IUGR) at different hemodynamic stages of fetal deterioration. Methods Brain blood perfusion was studied with PDU imaging, and the fractional moving blood volume (FMB V) was estimated in 56 growth-restricte