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OBJECTIVE: Accurate distinction between dementia subtypes is important for patient care and pharmacological treatment. Continuing systematic comparisons of clinical and neuropathological dementia diagnoses may provide a basis for further improvement of the diagnostic procedure. The purpose of this study was to investigate concordance between clinical dementia diagnosis and neuropathological findin
The first standards based on thermal manikin measurements were developed in the 1980s. In the Nordic countries tests for thermal insulation measurements of sleeping bags and cold protective clothing were developed. Similar standards were published in Germany by DIN and in the US by ASTM. At a European level, EN 342 describes test methods and requirements for cold protective clothing based on manik
This chapter presents a methodological analysis of the use of the efficient-market hypothesis in the recent financial crisis.
Intra cerebral tumours were inoculated into the brain of Fischer-344 syngeneic rats. After one week they were treated with either 5 or 15 Gy of Co-60-gamma radiation. The first immunization was given 1 hour before the radiation treatment and then two more times with 14-day intervals. Immunization was performed with 3 x 10(6) radiation sterilized IFN-gamma secreting tumour cells (N29) injected intr
By pulse-modulating a cw dye-laser beam and employing the delayed-coincidence technique, we have determined the natural radiative lifetimes of a number of atomic states in rare-earth atoms Eu, Dy, and Yb. In the measurements, which were performed on an atomic beam, exponential decay curves with good statistics were obtained using short measuring times. The general features of the technique are dis
Pathogenic microbes have evolved sophisticated molecular strategies to subvert host defenses. Here we show that virulent bacteria interfere directly with Toll-like receptor (TLR) function by secreting inhibitory homologs of the Toll/interleukin-1 receptor (TIR) domain. Genes encoding TIR domain containing–proteins (Tcps) were identified in Escherichia coli CFT073 (TcpC) and Brucella melitensis (Tc
Popular Abstract in Swedish Hur börjar en infektion och vad avgör vem som drabbas? Hur ser den sjukdomsframkallande bakterien ut, och hur försvarar vi oss mot dess angrepp? Vi studerar dessa frågor med urinvägsinfektioner som modell. De flesta urinvägsinfektioner orsakas av E. coli bakterier med speciella ytstrukturer som de använder för att angripa slemhinnan i urinvägarna. Genom sin starka förmUrinary tract infections (UTI) are among the most common infections in man. Despite their prevalence, information on the molecular mechanisms defects that explain the increased susceptibility to disease are lacking. This study focused on mucosal inflammation and the molecular mechanisms by which uropathogenic Escherichia coli activate this response. P fimbriae are expressed by most E. coli strain
Leukotriene B-4 (LTB4) is a potent lipid mediator of inflammation that acts primarily via a seven-transmembrane-spanning, G-protein-coupled receptor denoted BLT1. Here, we describe the synthesis and characterization of fluorescent analogs of LTB4 that are easy to produce, inexpensive, and without the disadvantages of a radioligand. Fluorescent LTB4 is useful for labeling LTB4 receptors for which n
A combination of hydrogen/deuterium (H/D) exchange and limited proteolysis experiments coupled to mass spectrometry analysis was used to depict the conformation in solution of HAMLET, the folding variant of human alpha-lactalbumin, complexed to oleic acid, that induces apoptosis in tumor and immature cells. Although near- and far-UV CD and fluorescence spectroscopy were not able to discriminate be
As an alternative to traditional top-down techniques for fabrication of one-dimensional devices we here report an approach wherein a bottom-up technique is used to create one-dimensional device structures. We use the vapor-liquid-solid growth method, in which a catalytically active gold nanoparticle forms a eutectic alloy with the nanowire constituents. Our method of growth allows atomically abrup
Type 1 diabetes is diagnosed at the end of a prodrome of β-cell autoimmunity. The disease is most likely triggered at an early age by autoantibodies primarily directed against insulin or glutamic acid decarboxylase, or both, but rarely against islet antigen-2. After the initial appearance of one of these autoantibody biomarkers, a second, third, or fourth autoantibody against either islet antigen-
