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The synthesis and characterization of all diastereomers of a linear symmetrically fused tris-Troger's base analogue are described. The diastereomers are unambiguously assigned as syn-anti 1a, anti-anti 1b, and syn-syn 1c isomers, by using X-ray diffraction analysis and NMR spectroscopy. For the first time, the anti-anti and the syn-syn diastereomers of a linear symmetrically fused tris-Troger's ba
During recent decades, research on quality of life has gained increasing interest. In gerontology, the assessment of objective as well as subjective dimensions is recommendable, and the most innovative research will involve the study of the interrelationships of several components. In empirical research objective environmental factors have rarely been explored. The aim of this study was to explore
The Auger-Doppler effect in the experimental spectra of HF and DF is presented. and the dynamics of ultra-fast dissociation in the core-excited state are discussed. The Doppler splitting of the atomic Auger peak is calculated and simulated using a classical model and a very good agreement is found between experiment and simulation. It is shown that the difference in photon energy relative to the r
Aims The glycosphingolipid sulfatide (sulfated galactosyl-ceramide) increases exocytosis of beta-cell secretory granules, activates K-ATP-channels and is thereby able to influence insulin secretion through its presence in the islets. A closely related compound, sulfated lactosylceramide (sulf-lac-cer), is present in the islets during fetal and neonatal life when, as in Type 2 diabetes, insulin is
T10 is a non-classical class Ib-like major histocompatibility complex (MHC) cell-surface antigen which binds directly to certain gammadelta T-cell receptors in the absence of any exogenous and endogenous ligands, such as peculiar lipids or glycolipids. The crystal structure at 2.5 Angstrom resolution of murine T10 was determined by molecular replacement using data from an almost perfectly twinned
Objective: During heat sterilization and during prolonged storage, glucose in peritoneal dialysis fluids (PDF) degrades to carbonyl compounds commonly known as glucose degradation products (GDPs). Of these, 3,4-dideoxyglucosone-3-ene (3,4-DGE) is the most cytotoxic. It is an intermediate in degradation between 3-deoxyglucosone (3-DG) and 5-hydroxymethyl-2-furaldehyde (5-HMF). We have earlier repor
In comparison with other decapods, the Caribbean spiny lobster Panulirus argus has little diversity in the external morphology of the setae on the mouth apparatus. In mouthpart areas that frequently touch food items only two types of setae can be distinguished: simple setae and cuspidate setae. Simple setae are by far more numerous. The ultrastructural data presented here show that both types of s
During the Devonian, 377 Ma ago, the Earth was impacted by a large celestial body, striking ground in the Siljan area in Dalarna, Sweden. The impact created what is today the largest confirmed impact structure in western Europe. Since its formation, the structure has however been heavily eroded, leaving no trace of the original crater. Today, it is instead recognizable due to the central plateau a
Bakgrund: Emergency Teamet skickar ut ERH-Kits då en efterfrågan från kunden uppstår, exempelvis efter en katastrofsituation. Emergency Teamet har blivit kritiserade för att inte ha svarat tillräckligt snabbt på efterfrågan och därför har Executive Director för UNFPA gett nya direktiv för att UNFPA ska svara snabbare och skapa bättre förutsättningar för att leverera snabbt i katastrofsituationer.
Denna uppsats undersöker huruvida investeringsavtal innebär för mycket begränsningar för värdländernas handlingar och om så är fallet, vad som kan göras för att åtgärda problemet. Uppsatsen erbjuder en översikt över några vanliga gällande regler som återfinns i investeringsavtal och går sedan vidare med att diskutera några internationella skiljedomar. Internationella investeringsavtal har kritiser
This study uses an intersectional approach to examine and understand how different social and cultural norms impact women’s agency when choosing infant feeding practice. The study wishes to broaden the debate on how women can succeed with breastfeeding or the infant feeding practice of her choice and decrease harmful premature introduction of solids such as Nestum®. Data was collected via group a
The aim of this study is to offer as detailed analysis as possible of the Compendium Saxonis, a late medieval abridgement of the famous historical work Gesta Danorum, written towards the end of the XII century by Saxo Grammaticus. Books I–IV and XVI have been used for this purpose. The study contains an introduction, two chapters and a conclusion. In the introduction, scarce information known abou
The aim of this study was to analyse rural tourism as a tool for poverty reduction, by examining the role of the regulatory framework, including the public and the private sector; and how the participation in rural tourism activities shapes people’s livelihood outcomes in San Pedro de Colalao, Argentina. A case study was carried out, which sought to gain an in-depth understanding about people’s li
The recombinant xylose-utilizing Saccharomyces cerevisiae TMB 3399 was constructed by chromosomal integration of the genes encoding Image-xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase (XK). S. cerevisiae TMB 3399 was subjected to chemical mutagenesis with ethyl methanesulfonate and, after enrichment, 33 mutants were selected for improved growth on Image-xylose and carbon dio
Radiative lifetimes of 11 levels in Cd I belonging to the 5s5p 1po1 and 5snd 3D1,2(n=6-9) and 5sns 3S1 (n=7,8) series, and of 5 levels of Cd II belonging to the 4d105p 2po1/2,3/2, 4d106s 2S1/2, and 4d105d 2D3/2,5/2
Human adenosine A2A and rat dopamine D2 receptors (A2A and D2 receptors) were co-transfected in Chinese hamster ovary (CHO) cells to study the interactions between two receptors that are co-localized in striatopallidal gamma-aminobutyric acid-(GABA)ergic neurons. Membranes from transfected cells showed a high density of D2 (3.6 pmol per mg protein) and A2A receptors (0.56 pmol per mg protein). The
The antilipolytic effect of insulin on human abdominal subcutaneous adipose tissue and skeletal muscle during local inhibition of cAMP-phosphodiesterases (PDEs) was investigated in vivo, by combining microdialysis with a euglycaemic, hyperinsulinaemic clamp. During hyperinsulinaemia, the glycerol concentration decreased by 40% in fat and by 33% in muscle. Addition of the selective PDE3-inhibitor a
No large randomized multicentre trial has evaluated the efficacy of radiofrequency ablation (RFA) vs. anti-arrhythmic drug (AAD) therapy as a first-line treatment of paroxysmal atrial fibrillation (AF). The Medical ANtiarrhythmic Treatment or Radiofrequency Ablation (MANTRA-PAF) trial is a randomized, controlled, parallel group, multicentre study designed to test whether catheter-based RFA is supe
Acrylamide exposure was investigated in subgroups of the EPIC study population (510 subjects from 9 European countries, randomly selected and stratified by age, gender, and smoking status) using hemoglobin adducts of acrylamide (HbAA) and its primary metabolite glycidamide (HbGA). Blood samples were analyzed for HbAA and HbGA by HPLC/MS/MS. Statistical models for HbAA and HbGA were developed inclu
