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The retinoid-related molecules (RRMs) ST1926 [(E)-3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid] and CD437 (6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid) are promising anticancer agents. We compared the retinoic acid receptor (RAR) trans-activating properties of the two RRMs and all-trans-retinoic acid (ATRA). ST1926 and CD437 are better RARgamma agonists than ATRA. We
The association between H. pylori infection and pancreatic cancer risk remains controversial. We conducted a nested case-control study with 448 pancreatic cancer cases and their individually matched control subjects, based on the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, to determine whether there was an altered pancreatic cancer risk associated with H. pylori inf
Background and aims:Heart transplantation (HT) constitutes the ultimate treatment choice for end-stage heart failure. Following HT, patients require life-long immunosuppressive treatment to prevent allograft rejection. Although survival has steadily increased over the last few decades, issues related to under- and over-immunosuppression remain common and continue to represent one of the most impor
Pseudomonas aeruginosa is the dominant pathogen causing chronic lung infections in patients with cystic fibrosis (CF). After an initial phase characterized by intermittent colonizations, a chronic infection is established upon conversion of P. aeruginosa from the non-mucoid to the mucoid, alginate-overproducing phenotype. During the chronic infection the isolation of both mucoid and non-mucoid iso
To prospectively study the prevalence of Lyme arthritis, 100 consecutive patients referred to a rheumatology out-patient clinic and 115 patients with a classified rheumatological disease were included. Individuals seropositive for antibody against the Borrelia burgdorferi sensu lato complex were examined for clinical signs or a history of Lyme borreliosis. Positive titres against B. burgdorferi s.
Abstract Deforestation and the use of fire to clear land have drastic effects on ecosystem functioning and compromise the continuity of many important ecosystem services. This is specially the case in tropical countries such as Madagascar, where people's reliance on forest exploitation and subsidence agriculture is driving severe forest decline. In this study we evaluated the effects of slash
Responding to an identified knowledge gap, the study aims to determine if smaller wind turbines located on top of existing urban buildings are more resource efficient (land utilization and economically) than large scale wind farms. To answer this question, using a GIS, the resource efficiency of the Roan wind farm in Northern Norway was compared to a theoretical modeled installation of small-scale
To evaluate the pharmacokinetics and safety of oral panobinostat in patients with advanced solid tumors and varying degrees of hepatic function. Patients with advanced solid malignancies, acceptable bone marrow and renal function, and normal or impaired hepatic function, per NCI-ODWG criteria, were eligible. Initially patients received a single oral dose of 30 mg panobinostat for a 1-week pharmaco
Loss of biodiversity is an immediate threat to the planet and if no actions are taken it is expected to accelerate. The highest species richness on smaller scale is found in semi-natural temperate grasslands, with one of the documented records from Stora Alvaret on Öland, Sweden. The area is protected under the Natura 2000-network and Länstyrelsen Kalmar are responsible for monitoring while local
The purpose of this study was to develop an understanding of how the perception of stress for HR-professionals within staffing- and recruitment, might differentiate when working more or less from home. An additional ambition was to develop an understanding of how the work characteristics, job-demand, control and support, could have an impact on the above association. To examine this, an explorator
Based on the extensive criticism surrounding the victimization of women in the women, peace and security agenda discourse, this essay seeks to analyze the discourse after the adaption of resolution 2122, a widely recognized step in the direction to focus more on women’s participation. The aim of the study is thus to analyze the discourse around women’s participation and agency on a global and nati
Inom musikpsykologi har många studier antytt att musik kan påverka emotioner. Denna kvalitativa studie sökte att utforska de emotionella och kognitiva effekterna samt användningar av musik av musiker, särskilt gällande coping och reglering av emotioner. Semi-strukturerade intervjuer utfördes med tio musiker. Datan analyserades genom användning av tematisk analys under ett kritisk realistiskt paradIn the field of music psychology, many studies have suggested that music can influence emotions. This qualitative study aimed to explore the emotional and cognitive effects and usage of music by musicians, especially pertaining to coping and regulating emotions. Semi-structured interviews were conducted with ten musicians. The data were analysed using thematic analysis under a critical realist par
Objectives: Wildlife in Kenya, much like globally, is under significant pressure. In Kenya alone, there has been a 60 percent decrease in species and the remaining wildlife is faced with habitat loss and climate change, among others. The study of conservation practices - responding to the many challenges underlying the “sixth mass extinction” - has never been more relevant. All the more so is the
Despite that freight transports account for a notable and increasing share of global greenhouse gas (GHG) emissions, previous studies have identified that buyers of freight transport services often do not engage sufficiently to reduce emissions from the freight transports they purchase. An aspect that has not been adequately investigated, however, is how transport purchasers are influenced by new
The purpose of this study is to assess the effort of Non-Governmental Organization in combating violence against women in Nigeria using an NGO known as Women Right Advancement and Protection Alternative (WRAPA). This study uses qualitative method in gathering empirical data as well as in the analysis. The interview guide was semi-structured interviews whereby WRAPA’s employees working at the organ
Denna studie syftade till att evaluera och undersöka eventuell förändring i psykologisk symtomnivå samt klienttillfredsställelse hos klienter som behandlats med kognitiv beteendeterapi eller psykodynamisk terapi på en utbildningsmottagning för blivande psykologer. Studien syftade även till att undersöka eventuella skillnader i resultatet mellan klienter i kognitiv beteendeterapi och psykodynamisk This study aimed to investigate and evaluate change in psychological symptom levels and client satisfaction in clients treated with cognitive behavioral therapy or psychodynamic psychotherapy at a training clinic for prospective psychologists. The study also aimed to examine possible differences in outcome between clients in cognitive-behavioral therapy and psychodynamic therapy, and to examine wh
Målet med opgaven er, at undersøge hvordan identiteten og selvfremstillingen ser ud på to datingsider, en ny nichet side; Mazily og en almen og bred; Match . Dette med udgangspunkt i smag og den distinktion der ligger bag konceptet hos datingsiden Mazily, der markedsfører sig som en datingside for "urbant kulturfolk". De nichede datingsider med fokus på interesser vokser frem, og den kla
This thesis explores the causes and ramifications of representing women in gender-equality advocacy within the realm of International Development cooperation’s. This study shows that through representing the issues of development and the people for whom they are aimed - we risk constructing and reconstructing conceptions of what the postcolonial feminist field of studies calls ´third world differe
Purpose: This thesis delves into whether acquisition experience is both a valid indicator of increased acquirer returns and leads to participating at certain points during an M&A wave through examining the differences between active and inactive acquirers. This study seeks to provide further understanding of acquisitions during M&A waves with particular interest focused on domestic transac
