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Transient activation of fibroblasts into contractile myofibroblasts is essential for extracellular matrix (ECM) production and remodeling during wound healing and tissue regeneration. While ECM-dependent mechanisms mediating transient activation is well studied, how fibroblasts switch from transient to a persistently activated state and drive fibrosis and aberrant tissue repair in diseases such as
Bakgrund: Patienter med avancerad gastrointestinal (GI) cancer har en hög symtombörda, vilket ofta medför behov av akutsjukvård. Integration av tidig, hem-baserad specialiserad palliativ vård (SPV) tillsammans med tumörspecifik behandling kan påverka behov av akut sjukvård.Metoder: Vid initiering av palliativ kemoterapi randomiserades patienter med avancerad GI-cancer till tidig hem-baserad SPV inBackgroundPatients with advanced gastrointestinal (GI) cancer experience a high symptom burden which frequently necessitates emergency care. Integration of early home-based specialised palliative care (SPC) with tumour-specific treatments may impact emergency healthcare use.MethodsAt the initiation of palliative chemotherapy, patients with advanced GI cancer were randomised to early home-based SPC
Uppsatsens syfte är att utreda vilka möjligheter det finns att ingå ett avtal trots parts passivitet. Begreppet passivitet används i betydelsen underlåtenhet att agera när part, under en process till synes syftande till att avtal ska ingås, normalt kan förväntas agera genom en positiv viljeförklaring, ett nekande eller ett förtydligande. Innan passivitetsfrågan behandlas närmare presenteras den The purpose of this essay is to investigate the possibilities of entering into a binding agreement despite the passivity of one of the parties. The term passivity is used to denote the lack of action when a party, during a process with the apparent aim of entering into an agreement, typically can be expected to act through a declaration of intent, a refusal or a clarification. Before a closer en
Investigating physical activity (PA) patterns as a detailed intensity spectrum instead of crude intensity categories have improved the ability to analyze the relationship between measured PA and health variables. The aim of this methodological study was to introduce and investigate the utility of using detailed PA intensity spectrum compared to crude PA intensity categories for comparison of PA be
Background: In the strive towards a circular economy, metal waste recycling is a growing industry. During the recycling process, particulate matter containing toxic and allergenic metals will be emitted to the air causing unintentional exposure to humans and environment. Objective: In this study detailed characterization of particle emissions and workplace exposures were performed, covering the fu
En nyligen utgiven studie från Södersjukhusets Akutmottagning för våldtagna visar att 70 procent av de tillfrågade våldtäktsoffren hade hamnat i ett tillstånd av frozen fright under övergreppet. Att ett offer hamnar i ett frystillstånd, frozen fright, innebär att förmågan att röra sig eller ge ljud ifrån sig minskas eller försvinner helt eftersom offrets utsätts för en traumatisk upplevelse. DennaA recently published study from Stockholm South General Hospital Emergency Clinic for Rape Victims shows that 70 per cent of the questioned victims had experienced a state of frozen fright during the rape. Frozen fright means a diminished or absent volitional movement accompanied by diminished vocal capacity in response to a traumatic event. The purpose of this thesis is to examine the perceptions
A search is presented for the production of the Standard Model Higgs boson in association with a high-energy photon. With a focus on the vector-boson fusion process and the dominant Higgs boson decay into b-quark pairs, the search benefits from a large reduction of multijet background compared to more inclusive searches. Results are reported from the analysis of 132 fb−1 of pp collision data at s
Cochleaimplantatanvändare (CI) har ofta svårigheter i situationer med bakgrundsljud. Hearing In Noise Test (HINT) mäter talförståelseförmågan för meningar i brus eller tystnad. HINT med brus beskrevs ursprungligen ha fast presentationsnivå för bruset och variabel för tal. Resultatet är ett signal till brusförhållande vid vilket deltagaren svarade 50% rätt. Lägre resultat var bättre. Resultaten frå
This Thesis examines what possibilities Member States have to impose levies on CO2 emissions from motor vehicles in the light of EU indirect tax legislation and the Eurovignette Directive. In this Thesis, carbon tax on fuel and a CO2 differentiated road toll are studied as levying options. Motor fuel is an excise good to which the harmonised EU excise duty system applies. Accordingly, the questi
Persistent circulating tumor DNA (ctDNA) during neoadjuvant treatment (NAT) of early breast cancer (EBC) indicates high-risk disease. Similarly, detection of ctDNA post-resection indicates molecular residual disease (MRD) and impending relapse. For ctDNA to be integrated into EBC management, accessible and scalable diagnostics are required. Here we apply an ultrasensitive, personalized tumor-infor
While organisms have evolved to cope with predictable changes in the environment, the rapid rate of current global change presents numerous novel and unpredictable stressors to which organisms have had less time to adapt. To persist in the urban environment, organisms must modify their physiology, morphology and behaviour accordingly. Metabolomics offers great potential for characterising organism
BACKGROUND: Treatment for breast cancer poses major challenges and leads to a variety of side-effects and problems that affect life for a long time. Experiences and symptoms vary, and research indicates a lack of structures for ensuring individualized rehabilitation. This qualitative focus group study aims to explore the experience of women with BC after participating in a complex randomized contr
Background: In clinic, a subjective visual estimation of a patient’s general health often guides interventions, yet little is known of how this assessment relates to objectively measured frailty. Aims: To characterize the relationship between these two assessments and explore the implication of discordance. Methods: The study was performed in the OPRA cohort of 75-year old community-dwelling women
The recent randomized controlled phase III CLEAR trial results are the last to complement immune checkpoint inhibitor (ICI)-based doublet combination therapies for treatment-naïve metastatic clear-cell renal cell carcinoma. The CLEAR trial demonstrated an improved progression-free survival (PFS), overall survival (OS), and an objective response rate (ORR) benefit for the combination of lenvatinib
We conduct a comprehensive review of embeddedness in entrepreneurship research. Although the term “embeddedness” is frequently used in this field of study, less is known about the ways in which it is operationalized and applied. Using criterion sampling, we analyse 198 articles in order to investigate how embeddedness is conceptualized and what role it plays in the extant entrepreneurship literatu
PICT (Pollution Induced Community Tolerance) to Cu is a useful and sensitive tool to assess the effects of Cu pollution in soils under laboratory conditions. However, in field situations, the absence of reference values, i.e. bacterial community tolerance to Cu baseline from non-polluted soils, make the method uncertain when we want to know if a soil is or is not polluted from a microbiological po
