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Mucosal pathogens trigger a local innate host response by activating epithelial cells. Bacterial adherence and Toll-like receptor 4 (TLR4) signaling have been implicated as key events in this process. This study addressed the molecular basis of the epithelial response to gram-negative infection in the human urinary tract. Mucosal biopsies were obtained from kidneys, ureters, and bladders of patien
To evaluate measurement properties of 2 brief outcome measures for carpal tunnel syndrome: the 6-item carpal tunnel symptoms scale (CTS-6) and the 2-item palmar pain scale (measuring severity of pain in the scar/palm and pain-related activity limitation). Our hypothesis was that the CTS-6 is responsive to change in symptoms after surgical treatment and the pain scale is a valid measure of surgery-
Context: Uncertainty is an unavoidable issue in software engineering and an important area of investigation. This paper studies the impact of uncertainty on total duration (i.e., make-span) for implementing all features in operational release planning. Objective: The uncertainty factors under investigation are: (1) the number of new features arriving during release construction, (2) the estimated
This paper reports tentatively some features of Semnam, a Central Aslian language spoken by some 250 people in the Perak valley, Peninsular Malaysia. It outlines the unusually rich phonemic system of this hitherto undescribed language (e.g. a vowel system comprising 36 distinctive nuclei), and proposes a practical orthography for it. It also includes the c. 1,250- item wordlist on which the analys
The territorial dimensions of the state are undergoing substantial changes. New political entities – such as cities and regions – are gaining in importance. Cities and regions are using different strategies in order to strengthen their position in the inter-regional competition. At first, the Swedish experience seems to be an exception to this general development. The relatively small cities of Sw
Anisotropy in the lowermost few 100 km of mantle, or D" region, is indicative of deformation-induced alignment of crystals and/or inclusions of material, and as such offers insights into the dynamic nature of this region. Observations of shear-wave splitting in phases that transit this region provide constraints on such anisotropy. We investigate the effects of lower-mantle seismic anisotropy on S
This paper concerns tourism and destination branding. The aim of this study is to contribute to a discussion, within the field of tourism studies, considering the relationship between place-specific qualities of destinations and the development of destination profiles and destination brands. Interreg III A programmes within cross-border regions of the Baltic Sea Area are used as examples to highli
Emission trading schemes (ETS) have emerged as a popular climate policy measure and are increasingly advocated as policy instruments to support the transition to a green economy. Using complementary analytical methods, this research investigated the institutional developments and complexities of the New Zealand Emissions Trading Scheme (NZ ETS). It focuses on (1) institutional experience and admin
Feel overwhelmed but realise the need to understand what's going on? Academic analytical frameworks can help.European countries, and Denmark in particular, are scrambling to respond to threats from US officials over the future of Greenland.Having successfully taken out the leadership of Venezuela in a raid on January 3, an emboldened US government is talking about simply taking Greenland for itsel
In this chapter, the author examines the European Union’s (EU) strategic choices and challenges in confronting the twin crises of climate change and biodiversity loss, and how these crises influence the EU’s ability to achieve its sustainability ambitions. The purpose is to analyse the coherence and effectiveness of EU climate and biodiversity policies, with a particular focus on the European Gree
The literature on diversity has grown rapidly in the last decade. Research from different areas has suggested that diversity is a critical factor in creativity, knowledge generation, innovation, and entrepreneurship at the level of organizations, cities, regions, and whole countries. This chapter introduces the topic of diversity and discusses its role for creativity, knowledge production, innovat
