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OBJECTIVE: Systemic administration of immunotherapeutics often gives rise to severe side effects. A local deposition, using secretory lysosomes of hematopoietic cells as vehicles for delivery, can overcome this problem. In the present study, the validity of this concept was investigated using retroviral transduction of the human soluble tumor necrosis factor-alpha receptor 1 (hsTNFR1) into murine

Microdosing is a new concept in drug development that-if implemented in the pharmaceutical industry-would mean that new drugs can be tested earlier in humans than done today. The human microdosing concept-or 'Phase 0'-may offer improved candidate selection, reduced failure rates in the drug development line and a reduction in the use of laboratory animals in early drug development, factors which w

Stochastic optimal power flow can provide the system operator with adequate strategies for controlling the power flow to maintain secure operation under stochastic parameter variations. One limitation of stochastic optimal power flow has been that only line flows have been used as security constraints. In many systems voltage stability and small-signal stability also play an important role in constrai

Stochastic optimal power flow can provide the system operator with adequate strategies for controlling the power flow to maintain secure operation under stochastic parameter variations. One limitation of stochastic optimal power flow has been that only limits on lineflows have been used as stability constraints. In many systems voltage stability and small-signal stability also play an important role i

Personalized patient care has gained increasing attention in recent years. Precise drug dosing is critical for patient safety and good clinical outcomes, especially in intensive care units, where patients often are in critical conditions. Such treatments can include stabilizing blood pressure and heart rate or maintaining safe anesthesia levels. However, the inter-patient variability in the drug r

To carry out the search mission, an additional narrow-angle video camera is installed on board the unmanned aerial vehicle (UAV). This video camera can be re-aimed at objects detected in the image frame received from the main (navigation) video camera. The movement of the additional video camera is carried out by two coordinated electric drives using direct current motors or brushless direct curre

This work is devoted to the development of a prototype of a small-sized information display system (SSIDS) for UAVs, which implements a human-machine interface. This system in field conditions in the presence of electromagnetic interference allows you to enter and adjust the flight task.The research used a liquid crystal display (LCD) based on the GC9A01 driver and a WeActStudio development board

Extremely thinned layers and possible folding make the dating of the deepest sections of ice cores especially challenging. Cosmogenic radionuclides have the potential to provide independent age estimates. The 36Cl/10Be ratio is largely independent of production rate changes that affect individual radionuclides and has an effective half-life of 384 kyr, making it an ideal tool for dating the new 1.

During the Last Glacial Period (LGP), Greenland experienced approximately 30 abrupt warming phases, known as Dansgaard-Oeschger (D-O) events, followed by cooling back to baseline glacial conditions. Studies of mean climate change across warming transitions reveal indistinguishable phase offsets between shifts in temperature, dust, sea salt, accumulation, and moisture source, thus preventing a comp

We report 17 new solar activity cycles with periodicities ranging from 1,700 to 18,000 years. Using Bayesian spectral analysis we determined for each cycle period, amplitude and phase for the past 145,000 years. These results were obtained by analyzing 10Be in the 2775 m long EDML ice core from Dronning Maud Land, Antarctica. In addition, we have augmented the 10Be data with synchronous ice accumu

In this paper, we present a framework to identify discrete-time, single-input/single-output, switched linear systems (SISO-SLSs) from input–output data measurements. Continuous state is not assumed to be measured. The key step is a deadbeat observer-based transformation of the SLS model to a switched auto-regressive with exogenous input (SARX) model. Discrete states are estimated by a three-stage

Ensuring availability is a critical requirement for the Internet of Things (IoT). CIDER, a recovery architecture, and its follow-up scheme, Lazarus, are solutions to address this issue. CIDER introduced a new hardware module, the Authenticated Watchdog Timer (AWDT), to keep IoT devices running in normal mode as long as trusted authenticated tickets are received from a hub. If valid tickets are not

Network Data Analytics Function (NWDAF) is a key component in 5G networks, introduced by 3G Partnership Project (3GPP) standards, that leverages machine learning to optimize network performance. The 3GPP standards mandate that mobile network operators should retrain NWDAF models to maintain accuracy. However, the presence of adversarial user equipment (UE) can introduce corrupted data points durin

This paper is concerned with the feasibility of the power flow in DC power grids with constant power loads. We introduce the notion of distance to infeasibility as a voltage stability index and robustness measure for power flow feasibility. In particular, we study the p-norm distance to infeasibility in the domain of the constant power loads, and show how this distance may be expressed as a mathem

This paper introduces P-expo, a do-it-yourself open-source software solution for enhancing online lectures. P-expo seamlessly integrates text, images, videos, webcams, and audio, with support for text-based tools like git for collaboration. Additionally, the paper introduces affordable DIY hardware components to enrich online education seminars, and presents a curated selection of accessible open-

Pseudo-Random Injections (PRIs) have been used in several applications in symmetric-key cryptography, such as in the idealization of Authenticated Encryption with Associated Data (AEAD) schemes, building robust AEAD, and, recently, in converting a committing AEAD scheme into a succinctly committing AEAD scheme. In Crypto 2024, Bellare and Hoang showed that if an AEAD scheme is already committing

Automated cryptanalysis has seen a lot of attraction and success in the past decade, leading to new distinguishers or key-recovery attacks against various ciphers. We argue that the improved efficiency and usability of these new tools have been undervalued, especially for design processes. In this article, we break for the first time the classical iterative design paradigm for symmetric-key primit

BACKGROUND: Telomere length (TL) and mitochondrial DNA copy number (mtDNAcn) variations are linked to age-related diseases and are associated with environmental exposure and nutritional status. Limited data, however, exist on the associations with mercury exposure, particularly early in life.OBJECTIVE: We examined the association between prenatal mercury (Hg) exposure and TL and mtDNAcn in 1,145 S