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The effect of the procedural variability in image acquisition on the quantitative assessment of bone scan is unknown. Here, we have developed and performed preanalytical studies to assess the impact of the variability in scanning speed and in vendor-specific γ-camera on reproducibility and accuracy of the automated bone scan index (BSI). Methods: Two separate preanalytical studies were performed:
The in-flow focusing method, introduced herein, enables rapid and straightforward measurements of the whole-channel acoustic energy of acoustic flow-through devices. The method is applied to assess the whole-channel acoustic energy and acoustophoretic efficiency frequency spectra of a bottom-actuated silicon-glass and a side-actuated glass chip. The input variables are the time-independent geometr
The need for radical transformations to respond to the environmental polycrises of climate change, biodiversity loss, and pollution has come to the forefront of political and academic debates. Nation states must have transformative capacity, meaning the ability to ignite, enable, and steer large-scale sustainability transformations. However, despite its importance, there remains a significant gap
In clinical practice, the glomerular filtration rate (GFR), a measurement of kidney functioning, is normally calculated using equations, such as the European Kidney Function Consortium (EKFC) equation. Despite being the most general equation, EKFC, just like previously proposed approaches, can still struggle to achieve satisfactory performance, limiting its clinical applicability. As a possible so
We report the realisation of spectroscopic broadband transmission experiments on quantum cascade lasers (QCLs) under continuous wave operating conditions for drive currents up to laser threshold. This technique allows, for the first time, spectroscopic study of light transmission through the waveguide of QCLs in a very broad spectral range (λ~1.5-12 μm), limited only by the detector response and b
Serious outcomes as stroke, arrythmia and death are relatively frequent in patients presenting with dizziness. Within 30 days almost one in five patients re-attended the ED due to dizziness and 2,8% needed ED evaluation due to a fall. Decision support tools to help identify serious conditions and predict preventable falls in ED patients with dizziness are needed.
Continuous experimentation (CE) is used by many internet-facing companies to improve the value of their products based on user feedback gathered, e.g. through on-line experiments using A/B testing. Frameworks and theories for CE have been derived through academic research from applications in large internet facing companies. To assist practitioners in a broader range of companies, we herein presen
BACKGROUND: De novo oligometastatic prostate cancer (omPCa) on prostate-specific membrane antigen (PSMA) positron emission tomography (PET) is a new disease entity and its optimal management remains unknown. OBJECTIVE: To analyze the outcomes of patients treated with cytoreductive radical prostatectomy (cRP) for omPCa on PSMA-PET. DESIGN, SETTING, AND PARTICIPANTS: Overall, 116 patients treated wi
Adolescence is a period of significant physiological changes, and likely a sensitive window to chemical exposure. Few nation-wide population-based studies of chemical body burdens in adolescents have been published. In the national dietary survey Riksmaten Adolescents (RMA) 2016–17, over 13 chemical substance groups, including elements, chlorinated/brominated/fluorinated persistent organic polluta
Background: Conservative management is an option for prostate cancer (PCa) patients either with the objective of delaying or even avoiding curative therapy, or to wait until palliative treatment is needed. PIONEER, funded by the European Commission Innovative Medicines Initiative, aims at improving PCa care across Europe through the application of big data analytics. Objective: To describe the cli
This article discusses an important panel held at ICIS 2011 in Shanghai to mark over thirty years of an ICIS institution, the ICIS Women's Breakfast. The panel addressed the controversial question-is there still a need for the ICIS Women's Breakfast? Panelists were asked if the ICIS Women's Breakfast could be seen as divisive, and if women's issues are different from issues of diversity such as ra
BACKGROUND: Lactiplantibacillus plantarum HEAL9 and Lacticaseibacillus paracasei 8700:2 positively affect the fecal bacteriome in children with celiac disease autoimmunity after 6 months of supplementation. The aim of the present investigation was to study the effects of Lactiplantibacillus plantarum HEAL9 and Lacticaseibacillus paracasei 8700:2 on the single-cell parasitome, with a primary focus
Aims: According to Braak's hypothesis, it is plausible that Parkinson's disease (PD) originates in the enteric nervous system (ENS) and spreads to the brain through the vagus nerve. In this work, we studied whether inflammatory bowel diseases (IBDs) in humans can progress with the emergence of pathogenic α-synuclein (α-syn) in the gastrointestinal tract and midbrain dopaminergic neurons. Methods:
BACKGROUND: Telomere length (TL) and mitochondrial DNA copy number (mtDNAcn) variations are linked to age-related diseases and are associated with environmental exposure and nutritional status. Limited data, however, exist on the associations with mercury exposure, particularly early in life.OBJECTIVE: We examined the association between prenatal mercury (Hg) exposure and TL and mtDNAcn in 1,145 S
This study examines how one may detect Parkinson’s disease (PD) by analyzing voice recordings made with a mobile phone. The key objectives include creating a model that ensures fair and unbiased predictions while maintaining interpretability that is consistent with the existing literature on PD. We introduce a novel group-wise scaling method to address typical age and biological sex biases in the
