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BACKGROUND: The minor T allele of rs2943641 near the gene encoding for insulin receptor substrate 1 (IRS1) has been associated with decreased risk of type 2 diabetes (T2D) and adiposity in genome-wide association studies. Dietary intake can influence the regulation of IRS1, and studies have indicated sex-specific associations between IRS1 and adiposity. OBJECTIVE: The objective was to examine the
BACKGROUND: Tumor development requires angiogenesis, and antiangiogenesis has been introduced in the treatment of cancer patients; however, how the cardiovascular phenotype correlates with cancer risk remains ill-defined. Here, we hypothesized that vasoactive peptides previously implicated in angiogenesis regulation predict long-term cancer risk.METHODS: We measured midregional proatrial natriuret
The function of the efflux pump P-glycoprotein (Pgp) and ABCB1 single nucleotide polymorphisms (SNPs) should be considered as important tools to deepen knowledge of drug nephrotoxicity and disposition mechanisms. The aim of this study is to investigate the association of C3435T, G2677T, C1236T, and T129C ABCB1 SNPs with Pgp activity and exposure to different immunosuppressive drugs in renal transp
Popular Abstract in Swedish Bränslecellen uppfanns redan 1838, det kommersiella genombrottet dröjde till 2007, den framtida potentialen är mycket lovande Domedagsprofetior angående växthuseffektens betydelse för livet på jorden når oss via media allt oftare. Bränsleceller är mycket lovande för ett framtida miljövänligt samhälle. Hög energieffektivitet och inga utsläpp av koldioxid, kväveoxider elFuel cells are electrochemical devices that directly transform chemical energy into electricity. They are promising for future energy systems, since they are energy efficient, able to use renewable fuels and, when hydrogen is used as fuel, there are no direct emissions of greenhouse gases. Various improvements are made during the recent years, however the technology is still in the early phases of
Background: High expression of the polymeric immunoglobulin receptor (PIGR) has previously been associated with a favourable prognosis in a few cancer forms, but its expression and relationship with clinical outcome in epithelial ovarian cancer (EOC) has not yet been reported. The aim of this study was therefore to examine the clinicopathological correlates and prognostic significance of PIGR expr
BACKGROUND: Radiostereometric analysis (RSA) is often used for evaluating implanted devices over time. Following patients who have had tantalum beads implanted as markers in conjunction with joint replacements is important for longitudinal evaluation of these patients and for those with similar implants. As doing traditional RSA imaging is exacting and limited to specialized centers, it is import
To identify prognostic factors after hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT). We retrospectively reviewed the combined experience at Toronto General Hospital and Hospital Vall d'Hebron managing HCC recurrence after LT (n = 121) between 2000 and 2012. We analyzed prognostic factors by uni- and multi-variate analysis. Median follow-up from LT was 29.5 (range 2-129.
Background: Despite an extensive literature on treatment interventions for patients with knee osteoarthritis, studies comparing the efficacy of different exercise interventions and living the life as usual on quality of life, cartilage quality and cost-effectiveness are lacking. The aim of the present study is to compare the efficacy of two different exercise programs compared to a control group i
Background: Resting conventional 12-lead ECG has low sensitivity for detection of coronary artery disease (CAD) and left ventricular hypertrophy (LVH) and low positive predictive value (PPV) for prediction of left ventricular systolic dysfunction (LVSD). We hypothesized that a similar to 5-min resting 12-lead advanced ECG test ("A-ECG") that combined results from both the advanced and conventional
In this study, we demonstrate that an integrated approach, combining palaeolimnological records and limnological monitoring data, can increase our understanding of changing ecological patterns and processes in shallow lakes. We focused on recent regime shifts in shallow Lake Krankesjon, southern Sweden, including the collapse of the clear-water state in 1975 and its subsequent recovery in the late
Background: Subjects with non-O ABO blood group alleles have increased risk of pancreatic cancer. Glycosyltransferase activity is greater for the A(1) versus A(2) variant, whereas O01 and O02 variants are nonfunctioning. We hypothesized: 1) A(1) allele would confer greater risk than A(2) allele, 2) protective effect of the O allele would be equivalent for O01 and O02 variants, 3) secretor phenotyp
Background: In previous meta-analyses, tea consumption has been associated with lower incidence of type 2 diabetes. It is unclear, however, if tea is associated inversely over the entire range of intake. Therefore, we investigated the association between tea consumption and incidence of type 2 diabetes in a European population. Methodology/Principal Findings: The EPIC-InterAct case-cohort study wa
The claims for the potential of boreal and sub-boreal forests to combat negative effects of climate change have been substantial with over half of Earth’s primary forests found within boreal and temperate regions of the Northern Hemisphere. Given the likely occurrence of more extreme climate events in the future, ascertaining a better understanding of how climate effects, such as profound fluctu
The situation of unaccompanied asylum-seeking children is nowadays a global issue affecting an important number of children all over the world. Nevertheless, the special needs and vulnerabilities of this group of children have not yet been effectively assessed. In fact, unaccompanied minors constitute the most vulnerable group among all asylum seekers and face human rights’ violations continuously
Cellular signalling and potential agents to combat prostate cancer Prostate cancer (PCa) arises as a result of uncontrolled proliferation of the cells in the male prostate gland. The male androgenic hormone, testosterone fuels prostate cancer cells. In the cells of the prostate, the androgen receptor (AR) acts as the signal receiver and effector of androgen, ultimately leading to the growth and s
The Po Delta Biosphere Reserve is located in Northern Italy and has attained recognition by UNESCO in 2015 due to its unique natural and cultural value. The reserve covers an area of approximately 140 000 hectares, supporting a human population of 118 000, as well as a complex mosaic of ecosystems, which are found in this transitional waters landscape. Administratively the area is highly fragment
The nexus between the far-right ideologies, toxic masculinity, and climate denial urgently calls for more research. Drawing on intersectional feminist theory and framing theory, a qualitative frame analysis based on the Estonian Far-Right Populist Party’s (EKRE) conservative news platform was conducted to scrutinize the role of toxic masculinity in legitimizing climate denial. As research reveals,
