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Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's disease

Clinical trials in patients with Parkinson's disease have shown that transplants of fetal mesencephalic dopamine neurons can form a new functional innervation of the host striatum, but the clinical benefits have been highly variable: some patients have shown substantial recovery in motor function, whereas others have shown no improvement and even a worsening in the 3,4-dihydroxyphenyl-L-alanine (L

A structure of persuasion in Galatians: Epistolary and rhetorical appeal in an aural setting

The purpose of this paper is to ponder the reception of the Letter to the Galatians in an aural setting. How did the first recipients react, what can we expect that they remembered after having listened to the letter? Are there structural elements in the letter that would have aided the aural reception of the letter? In four readings, the investigation traces textual indicators of interaction and

Orionid Meteor Stream

Based on data available at the IAU (International Astronomical Union) Meteor Data Center in Lund 60 precisely reduced photographic Orionid orbits and 17 video observed orbits are analysed. Mean photographic and video orbits are compared with the orbit of comet Halley. The Orionid meteoroid stream structure and radiant motion is studied, and compared with previous visual and photographic studies of

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Teknikavtalet Unionen/Sveriges Ingenjörer/Ledarna 1 april 2025–31 mars 2027 Kollektivavtal mellan Teknikarbetsgivarna och Unionen, Sveriges Ingenjörer samt Ledarna I äldre avtalstexter förekommer organisationernas tidigare namn eller förkortningar. Sveriges Verkstadsförening (VF) = Teknikarbetsgivarna Svenska Arbetsgivareföreningen (SAF) = Svenskt Näringsliv Svenska Industritjänstemannaförbundet (

https://www.saco.se/globalassets/lokala-akademikerforeningar/privat/siemens-energy-ab/dokument/1.-teknikavtalet-unionen-sveriges-ingenjorer-ledarna-2025-2027.pdf - 2026-05-15

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Sida 1 av 10 Ver. 2025-11-11 Saco-S-rådet vid Linköpings universitet Verksamhetsberättelse för verksamhetsåret 2025 1. Styrelsen och dess arbetsfördelning Rådets styrelse har under verksamhetsåret bestått av 10 ledamöter samt 3 suppleanter utsedda vid Saco-S-rådets styrelsemöte 2024-12-05. Därutöver utsåg årsmötet en valberedning. Till ordförande valdes: Krzysztof Marciniak, ITN, SULF Till 1:e vic

https://www.saco.se/globalassets/lokala-akademikerforeningar/statlig/linkopings-universitet-liu/dokument/arsmoteshandlingar/vb2025.pdf - 2026-05-15

cDNA microarrays detect activation of a myogenic transcription program by the PAX3-FKHR fusion oncogene

Alveolar rhabdomyosarcoma is an aggressive pediatric cancer of striated muscle characterized in 60% of cases by a t(2;13)(q35;q14). This results in the fusion of PAX3, a developmental transcription factor required for limb myogenesis, with FKHR, a member of the forkhead family of transcription factors. The resultant PAX3-FKHR gene possesses transforming properties; however, the effects of this chi

Attovial-based antibody nanoarrays.

Antibody array-based technology is a powerful emerging tool in proteomics, but to enable global proteome analysis, antibody array layouts with even higher density has to be developed. To this end, we have further developed the first generation of a nanoarray platform, based on attoliter sized vials, attovials, which we have characterized and used for the detection of complement factor C1q in human

Down-modulation of the antigen receptor by a superantigen for human B cells

B cell superantigens (SAgs) have been implicated in human diseases by demonstrating non-clonotypic expansion of B cells bearing certain immunoglobulin variable region genes. One possibility is that, during infection with microorganisms secreting SAgs, these potent molecules might modulate BcR expression. To test this hypothesis, we investigated the potential effects of a SAg, protein L from Peptos

Human intestinal lamina propria and intraepithelial lymphocytes express receptors specific for chemokines induced by inflammation

To determine which chemokine receptors might be involved in T lymphocyte localization to the intestinal mucosa, we examined receptor expression on human intestinal lamina propria lymphocytes (LPL), intraepithelial lymphocytes (IEL) and CD45RO+beta7hi gut homing peripheral blood lymphocytes (PBL). Virtually all LPL and IEL expressed CXCR3 and CCR5, receptors that have been associated with Th1(Tc1)/

Hyperinflammation and Fibrosis in Severe COVID-19 Patients : Galectin-3, a Target Molecule to Consider

COVID-19 disease have become so far the most important sanitary crisis in the XXI century. In light of the events, any clinical resource should be considered to alleviate this crisis. Severe COVID-19 cases present a so-called cytokine storm as the most life-threatening symptom accompanied by lung fibrosis. Galectin-3 has been widely described as regulator of both processes. Hereby, we present comp

Merger rates in primordial black hole clusters without initial binaries

Primordial black holes formed through the collapse of cosmological density fluctuations have been hypothesized as contributors to the dark matter content of the Universe. At the same time, their mergers could contribute to the recently observed population of gravitational-wave sources. We investigate the scenario in which primordial black holes form binaries at late times in the Universe. Specific

Dynamic studies on the sintering of compacted metal powders using an environmental scanning electron microscope

The sintering of pre-pressed powders of iron, copper and nickel has been studied in situ using an Environmental scanning electron microscope. The small samples were slowly heated to sintering temperatures in a reducing atmosphere. Continuous monitoring of the fracture surface of the sample revealed the initial formation of inter-particle bonds at relatively low temperatures for fine particles. The

BMD-Related Genetic Risk Scores Predict Site-Specific Fractures as Well as Trabecular and Cortical Bone Microstructure

CONTEXT: It is important to identify patients at highest risk of fractures. OBJECTIVE: To compare the separate and combined performances of bone-related genetic risk scores (GRSs) for prediction of forearm, hip and vertebral fractures separately, as well as of trabecular and cortical bone microstructure parameters separately. DESIGN, SETTING, AND PARTICIPANTS: Using 1103 single nucleotide polymorp