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Mechanisms: Are activities up to the job?

In this article I examine whether an influential theory of mechanisms proposed by Peter Machamer, Lindley Darden and Carl Craver can accommodate polygenic effects. This theory is both interesting and problematic, I will argue, because it ascribes a central role to activities. In it, activities are needed not only to constitute mechanisms but also to perform their causal role. These putative functi

The significance of form elements: a study of representational content of design sketches

The purpose of this paper is to understand the significance of form elements through the interpretations of design sketches. These interpretations are provided by designers themselves interpreting expressive characteristics of car images, and by students interpreting the sketches of designers' morphing sequences. In the experimental investigation of the sketching process through morphing sequence

Arthritis Susceptibility and Tolerance in Collagen Transgenic Mice

Popular Abstract in Swedish Är ledgångsreumatism en immunreaktion mot brosk? Kroppens immunförsvar bygger på ett antal olika vita blodkroppar, immunceller, som cirkulerar i blod och lymfa på spaning efter främmande och farliga "angrepp". Immuncellerna sägs svara på "angrepp", sådana immunsvar dirigeras av s k T-hjälparceller (Th-celler). Th-cellerna kommer från benmärgen, men de blir inte funktioThis thesis is based on work trying to understand the normal and pathological interactions taking place between the immune system and cartilage, specifically involving the cartilage-specific protein typ II collagen (CII). The work has been carried out in an experimental model of rheumatoid arthritis namely collagen type II induced arthritis (CIA) in mice. CIA can be triggered in mice of certain MH

Överföringsproblematiken med ett styrinstrument – en fallstudie av Kemira Water

Syftet med vår studie är att undersöka de problem som kan uppstå vid en överföring av ett styrinstrument, innehållande Key Performance Indicators, från en organisation till en annan i samband med förvärv. Uppsatsen utgår från en fallstudie av ett företag i kemibranschen. I vår fallstudie använder vi ett abduktivt angreppssätt och en kvalitativ metod. I den teoretiska referensramen utgår vi ifrån t

A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks

During DNA replication, chromatin is reassembled by recycling of modified old histones and deposition of new ones. How histone dynamics integrates with DNA replication to maintain genome and epigenome information remains unclear. Here, we reveal how human MCM2, part of the replicative helicase, chaperones histones H3-H4. Our first structure shows an H3-H4 tetramer bound by two MCM2 histone-binding

The Shadow Communication Model

Title: The Shadow Communication Model Seminar date: 2025-10-17 Course: Strategic Brand Management Authors: William Eriksson, Saga Nunstedt Strömberg, Ole Senkler Advisor: Mats Urde Keywords: Shadow message / Noise / Shannon Weaver / Semiotics / The Shadow Communication Model Research question: How do companies express shadow messaging in their advertisements, and in what ways does external n

Deep Generative Models for Fast Photon Shower Simulation in ATLAS

The need for large-scale production of highly accurate simulated event samples for the extensive physics programme of the ATLAS experiment at the Large Hadron Collider motivates the development of new simulation techniques. Building on the recent success of deep learning algorithms, variational autoencoders and generative adversarial networks are investigated for modelling the response of the cent

The sustainability reward : what does it take to undo climate ethical decisions in everyday life?

Today many of us strive to live as climate-friendly lives as possible, we stay informed with the ways that we can contribute and then try to alter our everyday habits accordingly. We often have an idea of what the best choice of transportation would be or that we should reduce our consumption in order to decrease our personal carbon footprint. Even with the best intentions our everyday-related dec

Ground deformation and groundwater dynamics : the role of interferometric synthetic aperture radar analysis in confined aquifer systems

Population growth and climate change have accelerated groundwater depletion globally. Interferometric synthetic aperture radar (InSAR) is a fairly new satellite remote sensing technique based on SAR images that offers a high-accuracy monitoring system of land surface motion driven by groundwater level changes in time and space that can never be achieved with point-in-situ measurements. In producti

Unveiling low-dimensional patterns induced by convex non-differentiable regularizers

This paper explores the asymptotic distributions of low-dimensional patterns in linear regression with regularizers such as Lasso, Elastic Net, Generalized Lasso, and SLOPE, as the number of observations n grows and the penalty increases at rate n. While the asymptotic distribution of rescaled estimation errors is well-understood, convergence of patterns lacks proof in the literature, even for Las

A Road Map for Integrating Academic Skills in a Bachelor’s Programme

Academic skills such as reading, writing, critical thinking and information literacy are foundational to university-level learning. However, although students often have a certain level of academic literacy on arrival, their skills do not necessarily match the context-specific requirements of higher education and often need to be explicitly taught. In contrast to ad hoc and isolated interventions,

On dissipative effects in thermo-electrically coupled systems : Hill–Mandel-type homogenisation, asymptotic expansions and two-scale convergence

Accurately predicting the macroscopic behaviour of heterogeneous materials, particularly in thermo-electrically coupled systems, remains a challenging problem in materials science and engineering. Against this background, this study presents a comprehensive framework for the homogenisation of electrical conductors subject to strongly coupled thermo-electrical processes in (quasi-)stationary settin

Introduction : Is the Current Tax System Fit for a Digitalized Economy?

Digitalization, including recent and rapid advances in the field of artificial intelligence (AI), constitutes a technological shift on a scale comparable to the introduction of the steam engine or electricity. This shift has altered the way we organize work and business, how we interact socially and shop. But what are the implications for other parts of the economy? What are the consequences for t

Conclusions : A Move Toward a Tax System Fit for a Digital and Global Economy

The tax system is essential for financing our public welfare and the public sector. The tax system and its capacity to generate tax revenue typically reflect the structure of the economy and as the economy changes the tax system needs to adapt. This anthology brings together different perspectives on how digitalization changes or may change the conditions for how the tax ecosystem functions, from