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In Parkinson's disease, the degeneration of dopaminergic neurons in substantia nigra leads to a decrease in the physiological levels of dopamine in striatum. The existing dopaminergic therapies effectively alleviate the symptoms, albeit they do not revert the disease progression and result in significant adverse effects. Transplanting dopaminergic neurons derived from stem cells could restore dopa
Both in the humanities and in the sciences, researchers make mistakes, and this is an essential part of the creative process. In a wider historical perspective, dead-ends can turn out to be the way forward. Two fathers of scientific systems, Aristotle and Carl Linnaeus, serve as an argument for the thesis that errors, or what we later label as such, are a necessary element of scientific work. In
Using Arctic sea ice concentration derived from passive microwave satellite observations in autumn and early winter over the 1979-2014 period, the Arctic region was objectively classified into several smaller regions based on the interannual sea ice variability through self-organizing map analyses. The trend in regional sea ice extent (RSIE) in each region was removed using an adaptive, nonlinear,
Background: Complex I (CI or NADH:ubiquinone oxidoreductase) deficiency is the most frequent cause of mitochondrial respiratory chain defect. Successful attempts to rescue CI function by introducing an exogenous NADH dehydrogenase, such as the NDI1 from Saccharomyces cerevisiae (ScNDI1), have been reported although with drawbacks related to competition with CI. In contrast to ScNDI1, which is perm
Although references to China were few and fragmentary, the example of a ‘stationary’ East Asian Empire featured importantly in Scottish Enlightenment ideas about religion and political economy. David Hume considered whether the apparently long-flourishing system of Chinese government, grounded in rationally deduced deistic ethics, could provide an example for Western nations. Later in the eighteen
Purpose: From the background of the dramatic increase of urban tourism, framed by the concept of overtourism, the purpose of this paper is to analyze and discuss current dynamic processes of urban tourism growth, as presented in the scientific literature. With the help of a literature review, this paper aims to discuss current definitions and conceptualizations of overtourism and discuss the drivi
This article aims to contribute to discussions and reflections upon the practice and theory of fire safety design. Are we reaching the results we want by the best available means? The theoretical framework of fire safety design is today restricted by a linear design process where mainly quantitative data and methods matters. A deterministic approach to safety ignores the decision-making context an
The photofragmentation of the isoxazole molecules producing ionized atomic and molecular fragments was investigated in the photon energy range of 9–32 eV, using synchrotron radiation excitation combined with ion time-of-flight spectrometry. Twenty-one well resolved cations were identified in the mass spectra of the isoxazole, and their appearance energies were determined. The yield curves of these
In order to combat the effects of climate change, it is important to use a combination of solutions to achieve carbon neutrality as soon as possible. Carbon capture and sequestration is one such technology that can be used to significantly reduce the carbon footprint of many industrial plants. A mature technology for CO2 capture, amine-based post-combustion capture, is readily available today. How
This book presents new socio-legal perspectives and insights on the social life of corruption and anti-corruption in authoritarian regimes.This book takes up the case of Uzbekistan—an authoritarian regime in Central Asia and one of the most corrupt countries in the world according to Transparency International’s Corruption Perceptions Index—and examines the corruption that developed in a tightly c
