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Background and purpose — Few prospective studies have reported the long-term effect durability of collagenase injections for Dupuytren disease. We assessed the 3-year treatment outcome of collagenase injections and predictors of recurrence. Patients and methods — We conducted a single-center prospective cohort study. Indication for collagenase injection was palpable Dupuytren’s cord and active ext

Elder law is often approached in terms of a 'body' of law. In this article, I argue for a contextualised and externalised perspective on the ageing individual as the subject of elder law. Elder law relates to the implications of law as an institutionalisation of society seen through the lens of older persons. The aged subject is a contested and differentiated social construct to be studied in rela

Background: Alcohol use disorders are a major but often unrecognized health problem. Alcohol markers can therefore be of great value for diagnosis, follow-up, and treatment evaluation. Phosphatidylethanol in blood (B-PEth) is an alcohol biomarker with higher clinical sensitivity and specificity than commonly used alcohol markers but has shown a considerable interindividual variation in relation to

In Parkinson's disease, the degeneration of dopaminergic neurons in substantia nigra leads to a decrease in the physiological levels of dopamine in striatum. The existing dopaminergic therapies effectively alleviate the symptoms, albeit they do not revert the disease progression and result in significant adverse effects. Transplanting dopaminergic neurons derived from stem cells could restore dopa

Both in the humanities and in the sciences, researchers make mistakes, and this is an essential part of the creative process. In a wider historical perspective, dead-ends can turn out to be the way forward. Two fathers of scientific systems, Aristotle and Carl Linnaeus, serve as an argument for the thesis that errors, or what we later label as such, are a necessary element of scientific work. In

Using Arctic sea ice concentration derived from passive microwave satellite observations in autumn and early winter over the 1979-2014 period, the Arctic region was objectively classified into several smaller regions based on the interannual sea ice variability through self-organizing map analyses. The trend in regional sea ice extent (RSIE) in each region was removed using an adaptive, nonlinear,

Background: Complex I (CI or NADH:ubiquinone oxidoreductase) deficiency is the most frequent cause of mitochondrial respiratory chain defect. Successful attempts to rescue CI function by introducing an exogenous NADH dehydrogenase, such as the NDI1 from Saccharomyces cerevisiae (ScNDI1), have been reported although with drawbacks related to competition with CI. In contrast to ScNDI1, which is perm

Although references to China were few and fragmentary, the example of a ‘stationary’ East Asian Empire featured importantly in Scottish Enlightenment ideas about religion and political economy. David Hume considered whether the apparently long-flourishing system of Chinese government, grounded in rationally deduced deistic ethics, could provide an example for Western nations. Later in the eighteen

Purpose: From the background of the dramatic increase of urban tourism, framed by the concept of overtourism, the purpose of this paper is to analyze and discuss current dynamic processes of urban tourism growth, as presented in the scientific literature. With the help of a literature review, this paper aims to discuss current definitions and conceptualizations of overtourism and discuss the drivi

In order to combat the effects of climate change, it is important to use a combination of solutions to achieve carbon neutrality as soon as possible. Carbon capture and sequestration is one such technology that can be used to significantly reduce the carbon footprint of many industrial plants. A mature technology for CO2 capture, amine-based post-combustion capture, is readily available today. How