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Complement factors are expressed in pancreatic islets and affect glucose induced insulin secretion
Effects of 17alpha-ethinylestradiol on immune parameters in the lizard Sceloporus occidentalis
We examined the effect of 17alpha-ethinylestradiol on immunity of the Western fence lizard, Sceloporus occidentalis. Injection of 17alpha-ethinylestradiol resulted in dose-dependent suppression of peripheral blood leukocyte levels as determined by cell counts, whereas total spleen cell levels were decreased only at higher doses of 17alpha-ethinylestradiol. In contrast, spleen cell proliferation wa
Smoking is an Independent Predictor of Low Bone Mineral Density, Prevalent Vertebral Fractures and Incident Fractures in Elderly Men. Mr OS Sweden.
SIVmac239 is a Potent Immunogen for the Induction of Neutralizing Antibody Response
Breaking the F-FCSR-H stream cipher in real time
The F-FCSR stream cipher family has been presented a few years ago. Apart from some flaws in the initial propositions, corrected in a later stage, there are no known weaknesses of the core of these algorithms. The hardware oriented version, called FCSR-H, is one of the ciphers selected for the eSTREAM portfolio. In this paper we present a new and severe cryptanalytic attack on the F-FCSR stream
Risk Factor Control in Diabetes - New Directions Based on Fixed Drug Combinations
Radiative lifetimes and transition probabilities of astrophysical interest in ZrII
Radiative lifetimes of 16 odd levels belonging to the 4d(2)5p configuration of Zr II have been measured using a time-resolved laser-induced fluorescence technique with a single-step excitation process either from the ground state or from metastable levels belonging to the 4d(2)5s and 4d(3) configurations. For 12 levels, there were no previous results available. The new experimental results and the
Combined serum IgG response to Helicobacter pylori VacA and CagA predicts gastric cancer
Helicobacter pylori is a major factor for the development of gastric cancer. The aim of this study was to define serum antibody patterns associated with H. pylori infection in patients with gastric cancer using a Western blot technique. Serum samples collected from 115 patients with gastric cancer and 110 age- and gender-matched patients without gastrointestinal diseases were tested for IgG antibo
The role of wnt antagonists in impaired beta cell exocytosis
A distinct metabolic profile at birth identifies children developing type 1 diabetes before 20 years of age
Systolic Blood Pressure And Risk Of Cardiovascular Disease In Type 2 Diabetic Patients, On Antihypertensive Treatment Or Not: National Data
Niche recycling through division-independent egress of hematopoietic stem cells
Hematopoietic stem cells (HSCs) are thought to reside in discrete niches through stable adhesion, yet previous studies have suggested that host HSCs can be replaced by transplanted donor HSCs, even in the absence of cytoreductive conditioning. To explain this apparent paradox, we calculated, through cell surface phenotyping and transplantation of unfractionated blood, that similar to 1-5% of the t
The Firm as an Institution for Product Design and Value Web Orchestration
Institutional theory of the firm focuses on firm boundaries and the activities firms internalize within their hierarchies. However, an examination of disintegrated firms that influences activities beyond the scope of their hierarchies suggests that firms also perform other economic functions. By analysing these functions, the aim of this paper is to suggest a theory of the firm that goes beyond in
Binding of Flavivirus Nonstructural Protein NS1 to C4b Binding Protein Modulates Complement Activation
The complement system plays a pivotal protective role in the innate immune response to many pathogens including flaviviruses. Flavivirus nonstructural protein 1 (NS1) is a secreted nonstructural glycoprotein that accumulates in plasma to high levels and is displayed on the surface of infected cells but absent from viral particles. Previous work has defined an immune evasion role of flavivirus NS1
Non-small cell lung cancer cells produce a functional set of complement factor I and its soluble cofactors
The complement system is important for protection from invading pathogens, removal of waste products and guidance of the immune response. Furthermore, complement can be also targeted to cancer cells. However, membrane-bound inhibitors over-expressed by certain types of tumor cells restrict the cytotoxic activity of complement. Herein we report that non-small cell lung cancer (NSCLC) cells produce
Human complement control and complement evasion by pathogenic microbes - Tipping the balance
Complement is a central homeotic system of mammals and represents the first defense line of innate immunity. The human complement system is aimed to maintain homeostasis by recognizing and removing damaged or modified self material, as well as infectious foreign microbes. However, pathogenic microbes also control and escape the host complement and immune attack. The increasing resistance of microb
Comparison of species identification of endocarditis associated viridans streptococci using rnpB genotyping and 2 MALDI-TOF systems.
Streptococcus spp. are important causes of infective endocarditis but challenging in species identification. This study compared identification based on sequence determination of the rnpB gene with 2 systems of matrix-assisted laser desorption ionization-time of flight mass spectrometry, MALDI Biotyper (Bruker) and VITEK MS IVD (bioMérieux). Blood culture isolates of viridans streptococci from 63
Surface receptors identify mouse NK1.1+ T cell subsets distinguished by function and T cell receptor type.
In vivo protein stabilization based on fragment complementation and a split GFP system.
Protein stabilization was achieved through in vivo screening based on the thermodynamic linkage between protein folding and fragment complementation. The split GFP system was found suitable to derive protein variants with enhanced stability due to the correlation between effects of mutations on the stability of the intact chain and the effects of the same mutations on the affinity between fragment
