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The human papillomavirus type 16 (HPV16) life cycle can be divided into an early stage in which the HPV16 genomic DNA is replicated, and a late stage in which the HPV16 structural proteins are synthesized and virions are produced. A strong coupling between the viral life cycle and the differentiation state of the infected cell is highly characteristic of all HPVs. The switch from the HPV16 early g
The dedicated production of biomass crops and the collection of residues in agriculture and forestry can lead to undesirable negative impacts and it is crucial that practices are found that ensure that these impacts are avoided or mitigated as far as possible. This chapter concerns the use of biomass for energy and the connection between increased bioenergy use and land use change (LUC). Land use
Just like a living organism, also the project has an anatomy, a life span and a purpose. A project has its given actors, given timeframe and phases, and a given goal. Towards the project’s completion, all these factors must intertwine perfectly, otherwise the project’s success will be challenged. Uncovering how these intricacies are held in place has been the epistemological foundation of this boo
Background: Immune complexes (ICs) are detectable in a variety of inflammatory diseases, including systemic lupus erythematosus (SLE), reflecting autoantibody binding to antigens. Though ICs are the main contributors to disease pathogenesis through FcγR-mediated inflammation and organ damage, IC levels are not part of the clinical assessment of SLE. The aim of this study was to explore the clinica
BACKGROUND: The incidence of cutaneous malignant melanoma (CMM) continues to increase in most countries worldwide and the majority are diagnosed with thin tumours (≤ 1 mm).OBJECTIVES: The aim of the present study was to investigate the melanoma-specific survival (MSS) as well as conditional MSS (CMSS) in patients with thin CMM in Sweden.PATIENTS AND METHODS: Clinical and histological parameters we
Phagocytosis is measured as a functional outcome in many research fields, but accurate quantification can be challenging, with no robust method available for cross-laboratory reproducibility. In this study, we identified a simple, measurable parameter, persistent prey-phagocyte association, to use for normalization and dose-response analysis. We apply this in a straightforward analytical method, p
Between 25 and 50 per cent of white dwarfs (WD) present atmospheric pollution by metals, mainly by rocky material, which has been detected as gas/dust discs, or in the form of photometric transits in some WDs. Planets might be responsible for scattering minor bodies that can reach stargazing orbits, where the tidal forces of the WD can disrupt them and enhance the chances of debris to fall on to t
Asteroid material is detected in white dwarfs (WDs) as atmospheric pollution by metals, in the form of gas/dust discs, or in photometric transits. Within the current paradigm, minor bodies need to be scattered, most likely by planets, into highly eccentric orbits where the material gets disrupted by tidal forces and then accreted on to the star. This can occur through a planet-planet scattering pr
Women seem to use the helmet when riding a bicycle less frequently than men. Two possible explanations for this behavior are that 1) it is less appalling to them because of lack of comfort or other reasons, or 2) they use bicycles in a more cautious way than men so they feel that they do not need the helmet as much. The present paper explores these two explanations in 5, 691 cyclists that responde
This article contributes to the theorisation of collaborative public diplomacy by introducing a perceptual approach. Engaging with the collaborative diplomacy paradigm developed to conceptualise public diplomacy in the context of non-traditional security threats and conflicts, as well as nation building, the article explores and compares perceptions of the European Union (EU) as a public diplomacy
Although the Tropical Rainfall Measurement Mission (TRMM) has come to an end, the evaluation of TRMM satellite precipitation is still of great significance for the improvement of the Global Precipitation Measurement (GPM). In this paper, the hydrological utility of TRMM Multi-satellite Precipitation Analysis (TMPA) 3B42 RTV7/V7 precipitation products was evaluated using the variable infiltration c
Social insurance administrative officers’ decision-making skills influence their efficiency at work and their general well-being. At work their tasks are characterised by complexity and a need for order and accountability. Moreover, cases should usually be handled and finalised within the imposed time frames. We investigated skills related to decision-making success among social insurance officers
Background: Primary hyperparathyroidism (pHPT) is caused by single- or multiglandular disease (MGD). Patients with MGD have an increased risk of complications at surgery and for persistence and recurrence after surgery. The study evaluated whether preoperative clinical and biochemical characteristics could predict MGD in patients with pHPT. Methods: We retrospectively evaluated patients operated 1
Immune checkpoint inhibitors (ICIs) have received much attention not least for melanoma since the award of the Nobel prize in 2018. Here, we review the current state of knowledge about the use of these monoclonal antibodies (mAbs) in non-small cell lung cancer (NSCLC). These drugs have generally been conditionally approved on limited early data and there are few long-term follow-up data from rando
Infections are associated with increased risk of MPO- but not PR3-ANCA-associated vasculitis - a population-based case-control study from southern sweden
Euro50 is a proposed optical telescope with an equivalent primary mirrordiameter of 50 m. Partners of the collaboration are institutes inSweden, Spain, Ireland, Finland, and the UK. The telescope will have asegmented primary mirror and an aplanatic Gregorian configuration withtwo elliptical mirrors. For a 50 m telescope there would be noeconomical advantage in going to a spherical primary. The siz
Popular Abstract in Swedish Antalet människor som insjuknar i cancer (cancerincidensen) runtom i världen ökar, exempelvis i Sverige har antalet diagnosticerade tumörer ökat med i snitt 2.1% per år de senaste 20 åren. Denna ökning förklaras bland annat av vår ökade livslängd och vårt val av livsstil. Trots detta har antalet människor som dör i cancer minskat de senaste 20 åren. Dessa motsägelsefullThe continual increase in incidence of cancer has created an urgent need for improved methods for diagnosis, prognosis and/or treatment. In this context, the field of biomarker research has expanded immensely during the last few years. This thesis, based on four original papers, revolves around protein biomarker discovery in cancer. For this purpose, an in-house design recombinant antibody microar
