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Metabolomic screening of fasting plasma from nondiabetic subjects identified alpha-hydroxybutyrate (alpha-HB) and linoleoyl-glycerophosphocholine (L-GPC) as joint markers of insulin resistance (IR) and glucose intolerance. To test the predictivity of alpha-HB and L-GPC for incident dysglycemia, alpha-HB and L-GPC measurements were obtained in two observational cohorts, comprising 1,261 nondiabetic
OBJECTIVEYounger age at menarche, a marker of pubertal timing in girls, is associated with higher risk of later type 2 diabetes. We aimed to confirm this association and to examine whether it is explained by adiposity.RESEARCH DESIGN AND METHODSThe prospective European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study consists of 12,403 incident type 2 diabetes
The end of the Cold War and the subsequent dismantling of the Soviet Union has brought about fundamental changes in the Baltic Sea region in the last decade. In view of these developments, this article addresses two central questions when it comes to Baltic Sea security—how can the current peace in the Baltic Sea region be characterized and what are the prospects and problems involved in achieving
The purpose of this thesis is to identify patents invented by researchers at Lund University, to describe the university inventors,and to understand the main factors that influence their patenting activities. The analysis focuses on inventors in relation to their environment. A number of factors influence scientists’ decisions to patent. Internal factors related to individuals such as solving the
Despite the considerable import of both response probability and response time for testing models of choice there is a dearth of chronometric studies of time- and space-order effects in discrimination of paired visual stimuli. In this study, systematic asymmetries in discriminating the brightness of paired visual stimuli are examined by way of binary response probability scaled in terms of log-odd
The Swedish model of industrial relations is analyzed with respect to some closely related dimensions: collective agreements - legislation, cooperation - confrontation, self-regulation - state regulation and centralisation - decentralisation. Both the historical development and the present state of the model are discussed. In an analytical table the dimension self-regulation - state regulation is
Background: Meniscus extrusion or hypertrophy may occur in knee osteoarthritis (OA). However, currently no data are available on the position and size of the meniscus in asymptomatic men and women with normal meniscus integrity. Methods: Three-dimensional coronal DESSwe MRIs were used to segment and quantitatively measure the size and position of the medial and lateral menisci, and their correlati
Epidemiological studies suggest health-protective effects of flavan-3-ols and their derived compounds on chronic diseases. The present study aimed to estimate dietary flavan-3-ol, proanthocyanidin (PA) and theaflavin intakes, their food sources and potential determinants in the European Prospective Investigation into Cancer and Nutrition (EPIC) calibration cohort. Dietary data were collected using
Background: the link between the vitamin D endocrine axis and frailty remains undefined, with few studies examining the joint effect of vitamin D and parathyroid hormone (PTH) levels. Our objective was to determine the association of frailty with serum 25-hydroxyvitamin D (25(OH) D) and PTH. Setting: cross-sectional analysis within the European Male Ageing Study (EMAS). Participants: a total of 1,
This article explores three entrepreneurial ventures that have evolved in proximity to online piracy. In reviewing the respective cases of Spotify, Skype, and The Pirate Bay, the argument outlines the radically divergent strategies with which the entrepreneurs have sought to legitimise their ventures and underlying technologies. The article concludes that 1) the context of practices labelled “pira
The chapter discusses problms of succession in the GCC states and how they are likely to impact regimes' responses to domestic and foreign demands for political reforms. It attempts to put succession issues in the context the emerging new order in the Gulf.
INTRODUCTION: People with severe haemophilia A have reportedly impaired health related quality of life (utility) mainly due to recurrent bleeding, arthropathy and treatment burden.AIM: To estimate utilities and evaluate their potential correlates - most importantly the joint status - among people with severe haemophilia A.METHODS: In this cross-sectional study, eligible participants had severe hae
PurposeThere is a growing demand for a concurrent development of product and packaging in order to better take into account the supply chain needs. Different tasks are required to integrate packaging and product development: 1) At the strategic level, it is necessary to define or refine an integrated development policy; 2) For each new development project, an adaptation of this policy must be unde
Wood based energy is the main source of cooking and heating fuel in Sub-Saharan Africa. Its use rises as the population increases. Inefficient cook stoves result in fuel wastage and health issues associated with smoke in the kitchen. As users are poor women, they tend not to be consulted on cook stove development, hence the need for participatory development of efficient woodfuel cooking systems.
Popular Abstract in Swedish Papillomvirus infekterar ett brett spektrum av ryggradsdjur, såsom människa, olika ap-arter, ko, älg, elefant, ren och bofink. Dessa virus kan ge så vitt skilda symptom som cancer och vårtor. De indelas efter vilken art de infekterar, och inom arterna efter skillnad i DNA-sekvens mellan olika isolat (typer). Hittills har 92 humana papillomvirus (HPV) typer beskrivits, oPapillomaviruses are a diverse, epitheliotropic group of viruses. Some genotypes are the main cause of anogenital cancer in humans; others can induce skin lesions. In order to investigate the occurrence of subclinical skin infections with human papillomavirus (HPV), a pair of degenerate primers (FAP59/64) was designed. Moist cotton-tipped swabs were used as a gentle method of sample collection. Di
A 10-bit, 100-MHz CMOS linear interpolation digital-to-analog converter (DAC) is presented. It includes a 16-tap voltage controlled delay line and a 10-bit binary-weighted DAC with a time-interleaved structure. The linear interpolation not only increases the attenuation of the DAC's image components, but also reduces the glitch of the binary-weighted DAC. The requirement for the analog reconstruct
Dendritic cells (DC) are a heterogeneous lineage of bone-marrow-derived leukocytes that serve as the link between innate and adaptive immunity. They are professional antigen-presenting cells that play an important protective and regulatory role in both health and disease. This thesis is based upon six original papers that deal with the function and transcription of human DCs, with focus on their r
