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Akt (also known as PKB) is a survival kinase frequently up-regulated in cancer; three isoforms of Akt exist, and among them Akt1 and Akt2 are the most widely and highly expressed. They share the same structure and activation mechanism and have many overlapping functions; nevertheless isoform-specific roles and substrates have been reported, which are expected to rely on sequence diversities. In pa
We examine the applicability of the extended law of corresponding states (ELCS) to equilibrium and non equilibrium features of the state diagram of the globular protein lysozyme. We provide compelling evidence that the ELCS correctly reproduces the location of the binodal for different ionic strengths, but fails in describing the location of the arrest line. We subsequently use Mode Coupling Theor
Popular Abstract in Swedish Om blodkärlen i ögat läcker eller om blodflödet stoppas får inte näthinnan den mängd syre och näring som den behöver. Detta tillstånd kallas ischemi och kan leda till att näthinnans celler skadas. Näthinnan ligger längst bak i ögat och fungerar som filmen i en kamera. Stavar och tappar registrerar ljus och signalen går via nerver till syncentra i hjärnan. Blodkärl (artäIdentification of the intracellular signal transduction pathways activated in retinal ischaemia may be important in revealing novel pharmacological targets. The retinal blood vessels are key organs in circulatory failure, and in this work the retinal vasculature was therefore examined separately from the neuroretina. The porcine eye has a typical primate-like architecture and is similar to the hum
The PHENIX experiment at RHIC has embarked on a broad range of upgrades to enhance its physics reach. One of the upgrades consists of a set of silicon vertex trackers that combine to cover the pseudorapidity range − 2.4 to 2.4. A description of the vertex detectors and some of their physics goals and capabilities will be given, as well as technology choices and results from prototype components.
Abstract: In the interface, between implant and bone or between the cement and bone, there will develop some amount of fibrous tissue. The synovial fluid, the synovium, the cartilage and the subchondral bone from the non-replaced knee compartment that had been exposed to wear particles were studied by histological analyses. These analyses showed polyethylene wear particles in all tissues except t
To increase the accuracy of molecular force fields a systematical and balanced improvement of the various terms included is needed. In this work, we have followed this strategy to improve the quality of the NEMO potential for the formaldehyde dimer by introducing local quadrupole moments and higher-order polarizabilities. It is found that inclusion of the quadrupole moment significantly improves t
To date there is no International standard on the verification and validation (V&V) of building fire evacuation models, i.e., model testers adopt inconsistent procedures or tests designed for other model uses. For instance, the tests presented within the MSC/Circ.1238 Guidelines for evacuation analysis for new and existing passenger ships provided by the International Maritime Organization are
Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) of adult individuals and function to produce and regenerate the entire blood and immune system over the course of an individual's lifetime. Historically, HSCs are among the most thoroughly characterized tissue-specific stem cells. Despite this, the regulation of fate options, such as self-renewal and differentiation, has remained elusi
Even though the first coronavirus pandemic was registered in 1965, SARS-CoV-2 was better acknowledged when it caused the worldwide pandemic in 2019 in which millions of individuals lost their lives. Due to its facile way of spreading from one individual to another, the number of infected cases has gone up to more than 750 million to this day. DENV is a very dangerous virus due to its asymptomatic
During the production of Tetra Pak’s packaging material, holes are cut for straws and caps, generating paperboard scraps known as confetti. These scraps must be removed from the machinery to prevent build-up and potential blockages. To design efficient extraction systems, experiments and simulations are employed to understand the phenomena of confetti transport. Confetti are introduced into a simp
Sjöfartsindustrin står för närvarande inför ett paradigmskifte i och med framväxandet av Maritime Autonomous Surface Ships (MASS). Dessa fartyg är utformade för att verka autonomt, utan mänsklig närvaro ombord. Den nuvarande rättsliga strukturen inom sjörätten bygger emellertid på antagandet att människor befinner sig ombord på fartygen, vilket har lett till uppkomsten av rättsliga frågor och osäkThe shipping industry is currently at the beginning of a transformative shift with the introduction of Maritime Autonomous Surface Ships (MASS). With MASS, ships will function without the need for humans onboard. However, the current legal framework within maritime law is built on the premise that humans are in fact onboard ships. Therefore, legal questions and uncertainties have risen alongside t
Despite previous studies extensively focusing on the domestic aspects of the Thai radical and left-wing movement, Thai left-wing publications, and its cultural politics, little is known about the comparative and transnational perspectives. This thesis examines the Thai Leftist Movement and its articulations from the 1970s to the early 1980s in Thailand and Europe, demonstrating how translation pla
The purpose of this research was to examine existing governance arrangements within the Australian federal public service and possible improvements for managing systemic risks at a national level. While there has been greater attention and discussion on systemic risks recently, research on how to govern systemic risk remains in its infancy. Where systemic risk governance is discussed, it is genera
Cultural values and beliefs within the jazz community have intrigued social scientists for a long time. Being one of the oldest recognised subcultures, jazz has been celebrated for its socio-political ambitions as well as the complexity and aesthetics of the music itself. Being recognised as an outlet for fighting social injustices throughout history, the notable exclusion of female jazz musicians
Dark matter is the problem of apparent missing mass in the universe, a discrepancy between observations of large-scale astronomical dynamics, and the observed matter density in large scale structures. The Light Dark Matter eXperiment (LDMX) is a proposed experiment to probe the realm of “light dark matter" in the mass range MeV to GeV. Light dark matter refers to a class of models where a new
The diffusion equation is a partial differential equation that describes how quantities such as heat, particles, or other diffusive substances spread out over time and space. This type of equation can be, at often times, quite challenging to solve analytically. Finding the exact solution is often difficult due to the com- plexity of the functions involved. This thesis focuses on solving the diffus
Consumers evaluate each step of their journey, which influences consumer’s expectations for further experiences and future intentions. Accordingly, past experiences are stored in consumers’ memory but each part of the journey will not be remembered. What drives further behaviours and intentions are the events of the experience that are considered more emotional and atypical, also called peaks. The
Purpose: The purpose of this thesis is to find out what pharmaceutical companies are doing in exploitation and exploration to improve R&D productivity. This research will also investigate the implications of management and control theories in combining exploration and exploitation in the context of pharmaceutical R&D. Methodology: Multiple case study interviews. Theoretical perspective
This paper focuses on the Danish ecovillage by the name of Svanholm, with a special attention to how different areas of sustainability is being understood and carried out in practice in the ecovillage. Through a long-term fieldwork and anthropological methods herein, the paper seeks to understand Svanholm with all its possibilities as well as challenges, whether it be in a technical, environmental
