Search results

Malignant melanoma (MM) is a frequent form of cancer with increasing incidence. 6-10% of patients with MM report a family history of MM, and in most populations 2% of unselected cases of MM carry a CDKN2A mutation. tvWe present a family with 24 cases of MM in nine persons from several generations, caused by a previously undescribed germ-line intronic mutation in CDKN2A. Through genetic counselling

In medical research, it is not unusual that risks are ruled out without any specification the exact risk that was ruled out. This makes it difficult to balance expected health benefits and risk of harm when choosing between alternative treatment options. International guidelines for reporting medical research results are sufficiently specific when it comes to establishing health benefits. However,

Context: GH replacement in adult GH-deficient patients may cause insulin resistance, raising concerns of potential increased risk of developing diabetes mellitus (DM).Objective: Our objective was to assess DM prevalence and incidence in the international Hypopituitary Control and Complications Study (HypoCCS) surveillance database.Design and participants: GH-treated patients enrolled into HypoCCS

The implementation of circular economy strategies, such as the reuse of building materials, represents a valid opportunity for the building and construction sector to diminish the consumption of raw materials and generate revenues and, thus, to contribute to the Sustainable Development Goals 11 and 12. However, the reuse of building materials is still limited. Previous studies suggest that one rea

We present the confirmation and characterization of three hot Jupiters, TOI-1181b, TOI-1516b, and TOI-2046b, discovered by the TESS space mission. The reported hot Jupiters have orbital periods between 1.4 and 2.05 d. The masses of the three planets are 1.18 ± 0.14 MJ, 3.16 ± 0.12 MJ, and 2.30 ± 0.28 MJ, for TOI-1181b, TOI-1516b, and TOI-2046b, respectively. The stellar host of TOI-1181b is a F9IV

The worldwide growing demand for whey proteins and derivatives requires more efficient and sustainable whey protein production processes. Whey is an important by-product from cheese manufacturing. In whey industry membrane processes such as microfiltration, ultrafiltration, nanofiltration and reverse osmosis are well-established to concentrate, fractionate and purify whey proteins as well as whey

Insect migration redistributes enormous quantities of biomass, nutrients and species globally. A subset of insect migrants perform extreme long-distance journeys, requiring specialized morphological, physiological and behavioral adaptations. The migratory globe skimmer dragonfly (Pantala flavescens) is hypothesized to migrate from India across the Indian Ocean to East Africa in the autumn, with a

Introduction: Previous bone density studies have generally shown bone resorption around both cemented and uncemented total hip arthroplasty (THA) stems. This is presumed to be due to stress shielding. Short stems have been introduced partly to preserve bone in the proximal femur by a more physiological loading of the bone. The purpose of this study was to evaluate bone remodeling around a short, f

Most stars form in a clustered environment. Both single and binary stars will sometimes encounter planetary systems in such crowded environments. Encounter rates for binaries may be larger than for single stars, even for binary fractions as low as 10-20 per cent. In this work, we investigate scatterings between a Sun-Jupiter pair and both binary and single stars as in young clusters.We first perfo

OBJECTIVES: Sedation and neuromuscular blockade protocols in patients undergoing targeted temperature management after cardiac arrest address patient discomfort and manage shivering. These protocols vary widely between centers and may affect outcomes. DESIGN: Consecutive patients admitted to 20 centers after resuscitation from cardiac arrest were prospectively entered into the International Cardia

BACKGROUND: The melanoma-specific survival (MSS) is heterogenous between stages and is highly dependent on the T stage for primary localized disease. New systemic therapies for metastatic cutaneous melanoma (CM) have been introduced since 2012 in Sweden.OBJECTIVES: To analyse the incidence and MSS time trends between 1990 and 2020 in Sweden.METHODS: Nationwide, population-based, and prospectively

Biopharmaceuticals are complex biological molecules that require careful storage and handling to ensure medication integrity. In this study, a work system analysis of real-world protein drug (PD) handling was performed with the following goals: identify main barriers and facilitators for successful adherence to accepted recommendations in PD handling, analyse differences in two organizations, and

The era of urban artificial intelligences has begun. It is already difficult to imagine urban futures without artificial intelligence (AI). In this final chapter, we draw on the volume’s empirical findings to explore the repercussions of urban AI and give evidence of how the emergence of AI in cities is reshaping urban society, urban infrastructure, urban governance, urban planning and urban susta

This chapter looks at three different cases, which extend from literature to protest, to examine the multimodality of translation and translanguaging in intercultural communication. The cases include excerpts from the novel On Earth We Are Briefly Gorgeous, the graphic novel Persepolis and practices of lip-sewing among refugees, as documented in online media. They represent different communicative