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Background: Meniscus extrusion or hypertrophy may occur in knee osteoarthritis (OA). However, currently no data are available on the position and size of the meniscus in asymptomatic men and women with normal meniscus integrity. Methods: Three-dimensional coronal DESSwe MRIs were used to segment and quantitatively measure the size and position of the medial and lateral menisci, and their correlati
The ATLAS detector at the LHC is used to search for high-mass states, such as heavy charged gauge bosons (W '), decaying to a charged lepton (electron or muon) and a neutrino. Results are presented based on the analysis of pp collisions at a center-of-mass energy of 7 TeV corresponding to an integrated luminosity of 1.04 fb(-1). No excess above Standard Model expectations is observed. A W ' with S
Abstract in UndeterminedIt has long been known that a major larger foraminifera turnover (LFT) occurred at the boundary between the Thanetian and Ilerdian stages, but its possible correlation with the Paleocene-Eocene thermal maximum (PETM) was unsuspected until the work of Baceta (1996), and has been controversial ever since. After summarizing the history of this controversy, we present informati
Popular Abstract in Swedish Varje år drabbas cirka 8000 svenska kvinnor av bröstcancer, och antalet nyinsjuknade ökar årligen med någon procent. I Sverige idag finns fler än 90 000 kvinnor som har avslutat eller är under behandling för sjukdomen. Med hjälp av nya återfallsförebyggande läkemedel har prognosen kraftigt förbättrats och 5-årsöverlevnaden är nästan 90 %. Den stora utmaningen i dagens bOne of the great challenges in breast cancer treatment today is to customize adjuvant treatment to each patient’s individual needs. To do this it is necessary to learn more about the prognostic and treatment predictive factors that determine the risk of relapse and response to a certain mode of treatment. This thesis describes studies on the effect of amplified in breast cancer 1 (AIB1), a coactiv
Different slope algorithms can result in totally different estimates. In the worst case, this may lead to inappropriate and useless modelling estimates. A frequent lack of awareness when choosing algorithms justifies a thorough comparison of their characteristics, making it possible for researchers to select an algorithm which is optimal for their purpose. In this study, eight frequently used slop
Metabolomic screening of fasting plasma from nondiabetic subjects identified alpha-hydroxybutyrate (alpha-HB) and linoleoyl-glycerophosphocholine (L-GPC) as joint markers of insulin resistance (IR) and glucose intolerance. To test the predictivity of alpha-HB and L-GPC for incident dysglycemia, alpha-HB and L-GPC measurements were obtained in two observational cohorts, comprising 1,261 nondiabetic
OBJECTIVEYounger age at menarche, a marker of pubertal timing in girls, is associated with higher risk of later type 2 diabetes. We aimed to confirm this association and to examine whether it is explained by adiposity.RESEARCH DESIGN AND METHODSThe prospective European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study consists of 12,403 incident type 2 diabetes
Background: The incidence of non-Hodgkin lymphoma (NHL) in early life has increased in recent decades, but the relevant risk factors remain largely unknown. We examined perinatal and family risk factors for NHL in childhood through young adulthood. Methods: We conducted a national cohort study of 3 571 574 individuals born in Sweden in 1973-2008 who were followed for incidence of NHL through 2009
We report on the multi-wavelength observations of PKS 1510-089 (a flat spectrum radio quasar (FSRQ) at z = 0.361) during its high activity period between 2008 September and 2009 June. During this 11 month period, the source was characterized by a complex variability at optical, UV, and gamma-ray bands, on timescales down to 6-12 hr. The brightest gamma-ray isotropic luminosity, recorded on 2009 Ma
Primary open angle glaucoma (POAG) is a major blindness-causing disease, characterized by elevated intraocular pressure due to an insufficient outflow of aqueous humor. The trabecular meshwork (TM) lining the aqueous outflow pathway modulates the aqueous outflow facility. TM cell adhesion, cell-matrix interactions, and factors that influence Rho signaling in TM cells are thought to play a pivotal
The subarctic environment of northernmost Sweden has changed over the past century, particularly elements of climate and cryosphere. This paper presents a unique geo-referenced record of environmental and ecosystem observations from the area since 1913. Abiotic changes have been substantial. Vegetation changes include not only increases in growth and range extension but also counterintuitive decre
Women in rural areas of South Africa battle with many structural issues, including unemployment, education and accessibility to health services, greatly delimiting family planning. However, socially constructed and internalized gender norms pose an additional and potentially greater barrier to family planning in traditional and patriarchal settings. This thesis aims to contribute to the growing re
Forces such as globalisation, digitalisation and changes in consumer behaviour have led to a discussion among practitioners as well as scholars whether the physical retail place will stay relevant or even exist in the future. One way for brick-and-mortar retailers to stay competitive is to adopt new and innovative business models and formats, alongside a focus on the customer experience and how to
Previous research in the field of Environmental Federalism has not reached an agreement on whether fiscal decentralization leads to an increase in environmental pollution, i.e. a race to the bottom, or decrease in it, i.e. a a race to the top. Farzanegan and Mennel (2012) point out that this discrepancy may be due to institutions. Employing the OLS estimator, they find that fiscal decentralization
This qualitative study examines the interrelation of corporate, organisational and social identity within the European Spallation Source, a big research facility under construction. The greenfield project is characterised by ongoing change, in which we explored the influences of identity layers on the diverse and rapidly growing workforce. As future scientific breakthroughs are uncertain, the indi
I analyze the effect of a large exogenous trade shock on mortality in the United States between 2002 and 2012. Following the example of Autor, Dorn, and Hanson (2013), I construct a variable that captures the difference in exposure to import competition stemming from differences in initial manufacturing employment structures. I avoid endogeneity issues by instrumenting US commuting zones’ exposure
Skatteflykt, skatteundandragande och aggressiv skatteplanering av företag underminerar staters förmåga att respektera, skydda och uppfylla mänskliga rättigheter eftersom stater berövas nödvändiga resurser för att förverkliga ekonomiska, sociala och kulturella såväl som medborgerliga och politiska rättigheter. Företags skattebeteenden har tidigare betraktats som en elefant i rummet inom Förenta natCorporate tax evasion, tax avoidance, and aggressive tax planning undermine states’ ability to protect, respect and fulfill human rights since states are deprived of necessary resources to realize economic, social and cultural rights as well as civil and political rights. Corporate tax has previously been called the elephant in the room within the United Nations’ (‘UN’) framework of Business and H
