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Deficiency of complement components within the classical pathway is associated with increased risk for immune complex disease. However, C2-deficient individuals often have a mild disease and about 50% are healthy. To study the importance of the different components for immune complex clearance, bovine serum albumin (BSA)/anti-BSA complexes were opsonized in human serum and the binding to erythrocy

Src homology 2 (SH2) domains recognize phosphotyrosine (pY)-containing sequences and thereby mediate their association to ligands. Bruton's tyrosine kinase (Btk) is a cytoplasmic protein tyrosine kinase, in which mutations cause a hereditary immunodeficiency disease, X-linked agammaglobulinemia (XLA). Mutations have been found in all Btk domains, including SH2, We have analyzed the structural and

Epitopes found on Mucin-1 are differentially expressed on tumour versus normal tissue. Such epitopes have also been shown to have a potential in immunotherapy and tumour detection. The major epitope explored in this context is located within the variable number of tandem repeats. It has however recently been demonstrated that this epitope exists in several sequence variants. The standard sequence

The interactions between molecules of a low molecular weight diblock copolymer of poly(ethylene oxide) (E) and poly(butylene oxide) (B), B8E41, at hydrophobic surfaces were investigated experimentally by using two surface force techniques and ellipsometry. Extended mean-field theory was employed to describe the adsorption of EB diblock copolymers at planar surfaces as well as the forces between su

The interaction behavior of DNA with different types of hydroxylated cationic surfactants has been studied. Attention was directed to how the introduction of hydroxyl substituents at the headgroup of the cationic surfactants affects the compaction of DNA. The DNA-cationic surfactant interaction was investigated at different charge ratios by several methods like UV melting, ethidium bromide exclusi

Mixed polymer-surfactant systems have broad applications, ranging from detergents, paints, pharmaceutical, and cosmetic to biotechnological. A review of the underlying polymer-surfactant association in bulk is given. While ionic surfactants bind broadly to polymers, nonionics only do so if the polymer has a lower polarity and can interact by hydrophobic interactions. Water-soluble polymers, which

Isothermal titration calorimetry is increasingly becoming a common tool for the investigation of surfactant association processes. This can be associated with the development of new, sensitive and easy-to-operate commercial equipment, allied with the advantage of producing simultaneous information on the main thermodynamic parameters associated with the process under investigation. However, a sign

Insertions and deletions of entire codons have recently been discovered as a mechanism by which B cells, in addition to conventional base substitution, evolve the antibodies produced by their immunoglobulin genes. These events frequently seem to involve repetitive sequence motifs in the antibody-encoding genes, and it has been suggested that they occur through polymerase slippage. In order to bett

Upon tissue injury and infection both stressed and dying cells can release proteins that normally reside inside the cells. Some of the released proteins become ligands of various cell surface receptors expressed by local cells and such proteins are denoted damage associated molecular patterns (DAMPs). Binding of some DAMPs to certain cell surface receptors induces signals emanating in the producti

Haemophilus influenzae protein E (PE) is a multifunctional adhesin, involved in direct interactions with lung epithelial cells and host proteins, including plasminogen and the extracellular matrix proteins vitronectin and laminin. We recently crystallized PE and successfully collected X-ray diffraction data to 1.8 Å. Here we solved the structure of a recombinant version of PE and analyzed differen

The Gauss-Lagrange stochastic wave model is known to produce irregular waves with realistic degrees of asymmetry. We present the basic structure of the model and illustrate three of its characteristic properties: front-back asymmetry, particle orbits, and average horseshoe pattern. We also study the effect of a linear filter in a wave energy converting (WEC) system on asymmetry and on average powe

Comparable country profile that describes the evolution and practice of corporate Sustainability and Responsibility (CSR) in Saudi Arabia.

In this paper, we investigate the social herding phenomenon known as informational cascades, in which sequential inter-agent communication might lead to epistemic failures at group level, despite availability of information that should be sufficient to track the truth. We model an example of a cascade, and check the correctness of the individual reasoning of each agent involved, using two alternat

Popular Abstract in Swedish Drömmen om evigt liv och evig ungdom är inte ny. Föreställningarna om vägen dit är ungefär desamma idag som för 300 år sedan. Men de tekniska möjligheterna har vidgat gränserna. Att förbli ung, eller åtminstone se ung ut, är ett ideal som växer sig allt starkare. Åldrande och död ska bekämpas, att hålla sig ung och att leva länge är viktigt. Det gäller att träna och skThe aim of this thesis is to explore discursive changes in conceptions of life course and ageing. In a sense the Life- Span embodies the boundaries of human existence, but furthermore, it symbolizes a discursive system with distinctive symbols and meaning, that regulates and re-construct a cultural context. Hence, a cultures notion of the Life-Span also reveals its images and apprehensions of agei

By the autumn of 1966, the PRC government had enjoyed seventeen years of uninterrupted and complete domestic information dominance. Independent collection of information was hampered by way of a CCP culture of secrecy and successfully enforced regimen of information curtailment. Of the changes in the political landscape triggered by Mao Zedong’s August 1966 decision to label part of government off