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We have used combined quantum mechanical and molecular mechanical free-energy perturbation methods in combination with explicit solvent simulations to study the reaction mechanism of the multicopper oxidases, in particular, the regeneration of the reduced state from the native intermediate. For 52 putative states of the trinuclear copper cluster, differing in the oxidation states of the copper ion

Galectins are defined by a conserved beta-galactoside binding site, which has been linked to many of their important functions in e.g. cell adhesion, signaling and intracellular trafficking. Weak adjacent sites may enhance or decrease affinity for natural beta-galactoside containing glycoconjugates, but little is known about the biological role of this modulation of affinity (fine specificity). We

Diffuse reflectance spectroscopy (DRS) is a rapid, non-invasive optical method widely adopted to gain diagnostic information of tissue. The most flexible approach to this method is a fiber-optic contact-probe used with a spectroscopy system. A challenge of this method is that the external pressure brought by the probe can significantly affect the tissue optical properties as well as the light coup

Abstract in UndeterminedThis paper examines vowel production in Swedish adolescents with cochlear implants. Twelve adolescents with cochlear implants and 11 adolescents with normal hearing participated. Measurements were made of the first and second formants in all the nine long Swedish vowels. The values in hertz were bark-transformed, and two measures of the size of the vowel space were obtained

Crayfish spermatophores are deposited on the body surface of the female during mating and remain there for a period of time before fertilization ensues. Post-mating changes in protein expression level in the noble crayfish Astacus astacus spermatophore were quantified. In-gel digestion and high resolution mass spectrometry were used for label-free protein quantification. One hundred twelve protein

Contemporary cognitive psychology is dominated by an individualistic and mentalistic approach to the mind. This Cartesian heritage is evident in studies of social understanding, that is, how we understand others. It is argued that this approach and metaphors like reading minds have failed, and should be replaced with a discursive approach, where public and shared socio-linguistic intenand normativ

Brain machine interfaces with chronically implanted microelectrode arrays for signal acquisition require algorithms for successful detection and classification of neural spikes. During the design of such algorithms, signals with a priori known characteristics need to be present. A common way to establish such signals is to model the recording environment, simulate the recordings and store ground t

Background Despite recent successes with biological agents as therapy for autoimmune inflammatory diseases such as rheumatoid arthritis ( RA), many patients fail to respond adequately to these treatments, making a continued search for new therapies extremely important. Recently, the prevailing hypothesis that reactive oxygen species (ROS) promote inflammation was challenged when polymorphisms in N

Cultural heritage has developed into an important tool in marketing and destination development projects. Cultural heritage, as well as multiplicity, is also a political concept that has become important in the academic and public debate. The aim of our study is to analyse cultural heritage as a tourism and marketing product in relation to multiplicity. The discussion focuses around how the story

We describe the characterization of the hydrodynamic properties of anisotropic magnetic nanoparticles using a combination of transmission electron microscopy (TEM) and dynamic as well as depolarized dynamic light scattering (DLS/DDLS). The particles used are nearly monodisperse hematite spindles with an average length of 280 nm and a minor axis of 57 nm, coated with a layer of silica of variable t

The goal of this paper is to combine corpus methodology with experimental methods to gain insights into the nature of antonymy as a lexico-semantic relation and the degree of antonymic canonicity of word pairs in language and in memory. Two approaches to antonymy in language are contrasted, the lexical categorical model and the cognitive prototype model. The results of the investigation support th

The business model concept is becoming increasingly popular within e-businesses and e-business research. However, the concept is often used relatively independently from theory, meaning model components and their interrelations are relatively obscure. This paper analysis three e-business models taxonomies based on a generic business model, which include customers and competitors, the offering, act

This volume contains a comprehensive evaluation of the hypthesis that the Gospel of Mark has been influenced by the theology of the apostle Paul. It discusses the history of this view from the nineteenth Century to the modern day, analyses possible historical Connections between the apostle and the evangelist, and compares and contrasts many major theological themes in both the epistles and the Go