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Hereditary cystatin C amyloid angiopathy (HCCAA) is an autosomal dominant disorder in which a cysteine proteinase inhibitor, cystatin C, is deposited as amyloid fibrils in the cerebral arteries of patients and leads to massive brain haemorrhage and death in young adults. A full length cystatin C cDNA probe revealed a mutation in the codon for leucine at position 68 which abolishes an Alu I restric

Today there is ample evidence that the Cognitive Interview (CI) enhances witnesses' memory. However, less is known about how the CI affects eyewitnesses' confidence. To address this shortcoming we conducted a study analyzing how realism in confidence was affected by the CI. All participants (n = 79) were first shown a filmed kidnapping. After 2 weeks we interviewed one-third of the participants ac

Under many circumstances, it might be adaptive for parents to bias the investment in offspring in relation to sex. Recently developed molecular techniques that allow sex determination of newly hatched offspring have caused a surge in studies of avian sex allocation. Whether females bias the primary brood sex ratio in relation to factors such as environmental and parental quality is debated. Progre

A mutant lacking the ability to express the surface-exposed lipoprotein protein D was constructed by linker insertion and deletion mutagenesis of a cloned DNA insert containing the protein D structural gene from a nontypeable Haemophilus influenzae strain (NTHi). An isogenic NTHi mutant was isolated after transformation of genetically competent bacteria. The transformant was unreactive to a protei

We consider gamma-ray bursts (GRBs) produced by the merger of a massive white dwarf with a neutron star. We show that these are likely to produce long-duration GRBs, in some cases definitely without an accompanying supernova, as observed recently. This class of burst would have a strong correlation with star formation, and occur close to the host galaxy. However, rare members of the class need not

Background There has been much debate about the value of screening mammography. Here we update the overview of the Swedish randomised controlled trials on mammography screening up to and including 1996. The Kopparberg part of the Two-County trial was not available for the overview, but the continuation of the Malmo trial (MMST II) has been added. The article also contains basic data from the trial

We discuss the recent discovery by Oppenheimer et al. of old, cool white dwarf stars, which may be the first direct detection of Galactic halo dark matter. We argue here that the contribution of more mundane white dwarfs of the stellar halo and thick disc would contribute sufficiently to explain the new high velocity white dwarfs without invoking putative white dwarfs of the dark halo. This by no

In particular, I look at how traces of Zhuangzi’s butterfly dream appear in the oneiric fictions of Argentinian writer Jorge Luis Borges, and how, in turn, Borges’ dream-worlds have inspired Chinese author Can Xue to create a new kind of literary dreamscape.

BACKGROUND: Increased intraocular pressure (IOP) has been shown to be one of the most important risk factors for developing glaucoma. Yet it has not been clearly demonstrated that IOP-lowering treatment can reduce the incidence of glaucoma damage in patients with ocular hypertension. The aim of the current paper was to report the results of a long-term study addressing this very problem.METHODS: W

Dissipative particle dynamics (DPD) have been widely used for the simulations of dynamics of both simple and complex fluids at nano/micro scales. In these simulations, periodic boundaries are usually employed in the main flow direction and the characterization of the flow and heat transfer is based on fully developed conditions. In the real nano/micro-fluidic devices, however, there are entrances

Many amputees have maps of referred sensation from their missing hand on their residual limb (phantom maps). This skin area can serve as a target for providing amputees with tactile sensory feedback. Providing tactile feedback on the phantom map can improve the object manipulation ability, enhance embodiment of myoelectric prostheses users and help reduce phantom limb pain. The distribution of the

BACKGROUND: After more than 4 decades experience of total knee arthroplasty (TKA), there is still a group of patients who are not satisfied with the outcome. In spite of the improvement of many aspects around the procedure, for unexplainable reasons, patient dissatisfaction is still approximately the same. We conducted this study to analyze correlations between preoperative psychological aspects a

Ultrasonic consolidation (UC) has been proven to be a suitable method for fiber embedment into metal matrices. To aid successful embedment of high fiber volumes and to ensure their accurate positioning, research on producing microchannels in combination with adjacent shoulders formed by distribution of the melt onto unique UC sample surfaces with a fiber laser was carried out. This paper investiga

Background: Monitoring the quality of clinical learning environments (CLEs) is immensely important in medical education. Objective indicators of the quality of the CLE can be used to measure learner perceptions and to inform educational improvements; however, many established tools were not designed for use in clinical settings and are not theoretically grounded. Our aim was to apply a new tool to