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Recently, we reported that CD40-/- mice, exhibiting exclusively T cell-independent IgA class switch recombination (CSR), demonstrated near normal levels of IgA plasma cells in the gut lamina propria (LP), despite the complete lack of germinal centers (GCs). In this study, we have extended our analysis focusing on how to reconcile these findings using flow cytometry and molecular markers for IgA CS

This chapter presents life cycle assessment (LCA) and its current and potential use as a tool of governance. LCA is considered as providing governance input in three different dimensions: (1) as results; (2) as a method; and (3) as a mindset. Life cycle approaches are increasingly informing policymaking and legislation, either as an abstract idea such as “the circular economy” or as calculation ru

In 2024 the European Declaration of Cycling was signed as a tri-institutional declaration by the European Commission, Council of the European Union and the European Parliament. For the first time, cycling was acknowledged as a fully fledged mode of transport in a EU-level framework and through it, cycling now sits officially on the agenda of the EU. Yet this level of political attention was for ma

In this introductory chapter we chart colonial aspirations and projects of early modern Scandinavian kingdoms and discuss political and economic thinking that fuelled and justified these projects. We situate Danish and Swedish colonial venture, ideology and economic concerns that stood behind the global expansion in the context of contemporary European thinking and politics.

Nanotechnology is the science of making and using very small structures. As the scales of the constructions become smaller, the existing methods of making these structures - lithography, etching and micromoulding - although constantly improving, will reach physical limits. To overcome the limitations and create smaller, designed and ordered structures, a so-called 'bottom-up' approach must be used

Background: Selection pressure exerted by pathogens can influence patterns of genetic diversity in the host. In the immune system especially, numerous genes encode proteins involved in antagonistic interactions with pathogens, paving the way for coevolution that results in increased genetic diversity as a consequence of balancing selection. The complement system is a key component of innate immuni

Increasingly warmer springs have caused phenological shifts in both plants and animals. In birds, it is well established that mean laying date has advanced to match the earlier food peak. We know less about changes in the distribution of egg-laying dates within a population and the environmental variables that determine this variation. This could be an important component of how populations respon

Bioarchaeology has the potential to substantially inform about ancient lifeways through osteological analyses of the remains of the once living individuals. This article provides insights of the demography and health of the people of ancient Hermione (Geometric-Roman period). A minimum number of 85 individuals from the Hermione necropolis was osteologically analyzed. Although the analysis was limi

Two-dimensional (2D) cell culturing implies the cultivation of cells, isolated from an organism, to permit growth in 2D. Two-dimensional tissue culture surfaces are made of different kinds of glass and plastics with various degrees of hydrophilicity. The hydrophilicity is determined by the surface chemistry, which determines the adsorption of proteins required for cell attachment. Cellular physiol

Purpose: The purpose of this paper is to investigate the heat and mass transport characteristics in microchannel reactors with non-uniform catalyst distributions. Design/methodology/approach: A two-dimensional model is developed to study the heat and mass transport characteristics in microchannel reactors. The heat and mass transport processes in the microchannel reactors with non-uniform catalyst

Universal Design for Learning (UDL) is considered an approach to include all students in the university. UDL is based on three main principles providing multiple means of Engagement, multiple means of representation, and multiple means of action and expression. It is relevant for teachers and departments to focus on more flexibility for students to get the required information, expressing their th

Public transportation (PT) is an essential system for cities to achieve sustainability. However, determination of proper locations for PT stations and finding suitable routes are critical decisions. This paper aims to propose a novel method to determine BRT stations and routes in the cities, using Fuzzy Inference System (FIS) and Binary Integer Programming (BIP). In the proposed method, first, a s