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Synthesis and Evaluation of New Thiodigalactoside-Based Chemical Probes to Label Galectin-3

New chemical probes were synthesized to label galectin-3. They are based on the high affinity thiodigalactoside ligand. The probes were synthesized with benzophenone or acetophenone moieties as the photolabel for covalent attachment to the protein. Besides labeling the protein, these aromatic photolabels also greatly enhance the affinity of the probes towards galectin-3, due to the interaction of

Algebraic Properties of Multilinear Constraints

In this paper the different algebraic varieties that can be generated from multiple view geometry with uncalibrated cameras have been investigated. The natural descriptor, V-n, to work with is the image of P-3 in P-2 x P-2 x ... x P-2 under a corresponding product of projections, (A(1) x A(2) x ... x A(m)). Another descriptor, the variety V-b, is the one generated by all bilinear forms between pai

High-throughput proteomics using antibody microarrays

Antibody-based microarrays are a novel technology that hold great promise in proteomics. Microarrays can be printed with thousands of recombinant antibodies carrying the desired specificities, the biologic sample (e.g., an entire proteome) and any specifically bound analytes detected. The microarray patterns that are generated can then be converted into proteomic maps, or molecular fingerprints, r

Soluble pilin of Neisseria gonorrhoeae interacts with human target cells and tissue

Pili of Neisseria gonorrhoeae are phase-variable surface structures that mediate adherence to host target cells. Each pilus is composed of thousands of major pilus subunits, pilins, pilus-associated protein PilC, and possibly other components. Piliated and nonpiliated gonococcal clones may secrete a soluble smaller pilin (S-pilin) that is cleaved after amino acid 39 of the mature pilin protein. He

Understanding the Urban Sharing Economy

This book considers the potential solutions that the sharing economy offers to tackle the increasing challenges of urbanisation and sustainability facing cities. It emphasises the need for robust policies to ensure that the sharing economy supports urban sustainability and resilience by promoting more efficient and circular use of urban resources through practices like car-sharing, accommodation r

Selection bias of ideas for sustainability-oriented innovation in internal crowdsourcing

Decision biases reinforce firms’ tendency to develop innovations based on narrow economic motivations. Consequently, sustainability-oriented ideas explicitly targeting social and environmental issues are easily discarded in idea selection when trade-offs between economic and sustainability values are faced. Given the so far limited knowledge about how sustainability-oriented ideas are developed an

Poverty, Incentive Alignment and Resilience to Economic Shrinking - A Conceptual Proposal

Recent research has highlighted the importance of reducing economic shrinking—periods of negative per capita growth—for long-term development. Building on this literature, this chapter proposes a new framework explicitly connecting the dynamics of poverty eradication to the dynamics of resilience to economic shrinking. It argues that a key driver of this resilience is the alignment of incentives b

Winters restrict a climate change–driven butterfly range expansion despite rapid evolution of seasonal timing traits

Climate change pushes species toward higher latitudes and altitudes, but the proximate drivers of range expansions vary, and it is unclear whether evolution facilitates climate change–induced range changes. In a temporally replicated field experiment, we trans-located wall brown butterflies (Lasiommata megera) descending from range interior and range margin populations to sites at 1) the range int

MEDIATIZATION, RELIGION, AND POLITICS

This chapter discusses how processes of mediatization shape the increasing visibility and contestation of religion in public debate. Mediatization captures the interrelated processes of change between media technologies, institutions, and practices and other parts of society and culture. The first part presents a theoretical framework for the interplay between politics and traditional news media a

Haunting of the Cultural Past: Unreliability, Class and the Spectral in Sarah Waters’ The Little Stranger

Sarah Waters is an acclaimed author of several bestselling and award-winning novels. The existing body of research on Sarah Waters’ novel The Little Stranger has been valuable and mostly engages with and suggests a correlation between class and the hauntings taking place at Hundreds Hall. Some scholarly research has also explored the unreliable narration of the novel by focusing on different theme

CURRENT DEVELOPMENTS IN MEDICAL RADIATION PHYSICS AND RADIATION PROTECTION

The paper reviews current trends and future directions for diagnostics and therapy with ionizing radiation. Recent advances in medical physics applied to radiation therapy, diagnostic radiology, nuclear medicine, MRI, and radiation safety are summarized. Today, much of the development is concentrated on providing conditions for individualized diagnostics and therapy for the patient, which requires

Linguistic Relativity and Multilingualism

The current entry summarizes research bringing together the linguistic relativity hypothesis (the idea that language affects thought, in predictable ways) and the field of bi/multilingualism, broadly conceived to include learning, knowledge, and use of more than one language. After a brief historical introduction, the entry covers empirical research conducted in five main domains of enquiry, namel

A Marxist reading of John Steinbeck's The grapes of wrath: highlighting inequality issues through critical literacy in the ESL classroom

This essay explores how a critical reading of the novel The Grapes of Wrath (1939) can inform teachers when discussing inequality issues in the ESL classroom. The main questions being investigated are how the novel The Grapes of Wrath reveals oppressive and unequal power relationships, and how a critical reading of the novel can be used when teaching and informing others about inequality. In this

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