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Interaction assessments in correlated and autocorrelated environments

Natural food webs are embedded in a variable environment, which causes population densities to fluctuate, despite a potential stable equilibrium. Population interactions as well as the characteristics of the environmental fluctuations determine the resulting population dynamics. Populations sensitive to the same kind of environmental disturbances will show correlated responses in their respective

Ideation and ability: When actions speak louder than words

We present an approach and examples of design artefacts from on-going work on how children with profound disa-bilities can participate in formative design processes. It involves the pedagogical use of digitally interactive mul-tisensory environments. Rather than mimic participatory design from more symmetrical contexts, we address po-tentials in the situation at hand as well as the key issues of v

Synthesis of 1,2,3-triazole-linked galactohybrids and their inhibitory activities on galectins

Here a synthesis of novel galactose-1,2,3-triazole conjugates is described. The title compounds were obtained from 3-azido-3-deoxy-1,2: 5,6-di-O-isopropylidene-α-D-galactofuranose via a copper catalyzed azide-alkyne 1,3-dipolar cycloaddition reaction. It was demonstrated that the title compounds in their isopropylidene-protected form tend to chelate copper. The copper content can be diminished to

Design of recombinant antibody microarrays for serum protein profiling: Targeting of complement proteins

Antibody-based microarrays is a novel technology with great promise for high-throughput proteomics. The process of designing high-performing arrays has, however, turned out to be challenging. Here, we have designed the next generation of a human recombinant scFv antibody microarray platform for protein expression profiling of nonfractionated biotinylated human plasma and serum proteomes. The setup

MiR-129-5p is required for histone deacetylase inhibitor-induced cell death in thyroid cancer cells

The molecular mechanism responsible for the antitumor activity of histone deacetylase inhibitors (HDACi) remains elusive. As HDACi have been described to alter miRNA expression, the aim of this study was to characterize HDACi-induced miRNAs and to determine their functional importance in the induction of cell death alone or in combination with other cancer drugs. Two HDACi, trichostatin A and vori

Eta decays at and beyond p(4) in Chiral Perturbation Theory

An overview is given of Chiral Perturbation Theory and various applications to eta decays. In particular. the main decay eta --> 3pi is discussed at the one-loop level, and estimates of the higher order corrections are given. The importance of p(6) and higher order effects in double Dalitz and eta --> pi(0)gammagamma decays is pointed out. In all these cases the need for new experimental results i

Psychosocial factors, lifestyle, and fetal growth - The added value of both pre- and post-natal assessments

Background: Psychosocial resources as well as lifestyle habits during pregnancy have been shown to effect the risk of having a small-for-gestational-age (SGA) child. Most previous studies are based on a single assessment of these exposures, which does not take into account the possibility of different effects during early add late stages of pregnancy. Methods: The impact of psychosocial and lifest

A Charter Moment: Restructuring Governance for Sustainability

We are living in a highly dynamic, human-dominated Earth System in which non-linear, abrupt and irreversible changes are not only possible but also probable. These changes require institutional structures capable of steering human society away from critical tipping points and irreversible change and ensuring sustainable livelihoods for all. We see 2012 as a charter moment, a historic opportunity t

Epitope shift of proteinase-3 anti-neutrophil cytoplasmic antibodies in patients with small vessel vasculitis.

Summary Anti-neutrophil cytoplasmic antibodies against proteinase 3 (PR3-ANCA) are used as diagnostic tools for patients with small vessel vasculitis (AASV). We have produced chimeric mouse/human PR3 molecules and investigate changes in reactivity over time and the possible relationship between epitope specificity and clinical course. Thirty-eight PR3-ANCA-positive patients diagnosed between 1990

Ny strategi för vetenskaplig bokpublicering vid Lunds universitet

Två förslag till en bättre publiceringsverksamhet vid Område HT och vid Lunds universitet. Rapport från projektet HT-områdets bokpubliceringar. Rapporten innehåller förutom de två förslagen också kort historisk bakgrund, nationell och skandinavisk jämförelse och inventering av HT-forskarnas publiceringar. Dessutom sammanfattas två väsentliga internationella diskussioner: hur universitetsförlagen

Changing minds by tracking eyes: Dynamical systems, gaze and moral decisions

Decision making is a dynamic process. Alternatives compete over time, and this competition plays out in sensorimotor processes. This is true not just for perceptual decisions or simple categorisation tasks, but also for moral decisions, which are the outcome of a complex interplay of intuition, emotion and reasoning. In this experiment, we first establish a descriptive and causal link between gaze

Remote fluorescence lidar imaging of monuments: the Coliseum and the Lateran Baptistery in Rome

On site remote laser-induced fluorescence measurements have been performed with application towards non-movable objects. This paper describes the application of non-invasive hyperspectral fluorescence imaging to two masonry monuments, the Coliseum and the Lateran Baptistery in Rome, during a joint Italian-Swedish experiment. The mobile systems of Lund Institute of Technology, Sweden, and CNR-IFAC,

Kampen om historien - Ådalen 1931 - Sociala konflikter, historiemedvetande och historiebruk 1931-2000

Popular Abstract in Swedish Det finns en skillnad mellan historia som vetenskap och historia som historiskt minne, som boken vill fästa uppmärksamhet på. Ådalen som motbild till det trygga Folkhemmet är en bild av hur vi kan uppleva verkligheten. Inte nödvändigtvis hur den såg ut. Vår uppfattning om vad som hänt kan vaa nog så verklig när vi handlar, agerar och tolkar omvärlden. Det är denna tolknThe prelude to this thesis is provided by the dramatic scenes that took place in Ådalen. During a demonstration, four men and one young woman were shot to death and five others injured by military troops ordered to Lunde harbour. Inspired by a number of other researchers (Koselleck, Samuel, Somers, Stråth, Södring, Jensen and Burke, to name a few), my investigation has analysed how the story of th

Self-assembled aggregates of the carotenoid zeaxanthin: time-resolved study of excited states

In this study, we present a way of controlling the formation of the two types of zeaxanthin aggregates in hydrated ethanol: J-zeaxanthin (head-to-tail aggregate, characteristic absorption band at 530 nm) and H-zeaxanthin (card-pack aggregate, characteristic absorption band at 400 run). To control whether J- or H-zeaxanthin is formed, three parameters are important: (1) pH, that is, the ability to

Simulation of charged colloids in solution

Physicochemical properties of solutions of charged colloids are often dominated by the electrostatic interactions present in such systems. A full determination of these properties constitutes a highly nontrivial many-body problem involving long-range interactions. In electrostatically strongly coupled systems, it is essential to explicitly include both the charged colloids and the small ions in th