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The clinical trials with intrastriatal transplantation of human fetal mesencephalic tissue, rich in dopaminergic neurons, in Parkinson's disease (PD) patients show that cell replacement can work and in some cases induce major, long-lasting improvement. However, owing to poor tissue availability, this approach can only be applied in very few patients, and standardization is difficult, leading to wi

Glycoproteins are ubiquitous in nature and fundamental to most biological processes, including the human immune system. The glycoprotein carbohydrate moieties, or glycans, are very diverse in their structure and composition, and have major effects on the chemical, physical and biological properties of these glycoproteins. The hydrolysis of glycoprotein glycans by bacterial glycosidases can have dr

Due to the significant increase in pediatric trunk computed tomography (CT) examinations, there is a need for a reliable approach of conducting effectivedose estimate for such procedures. The current study is based on two dosimetric anthropomorphic phantoms representing a 1-year and a 5-year old child. Effectiveand equivalent tissue doses from CT examinations of the trunk were determined by thermo

Establishing diagnostic reference levels (DRLs) in a big country is complicated due to differences in radiological practice between different regions. In 2009-2014, a dose survey was performed in six Russian regions. Based on the results of the survey, preliminary DRLs for conventional X-ray examinations were established on a national level. Additionally, the local authorities were granted the pos

The cluster of pathologies comprising the metabolic syndrome (MetS) includes increased waist circumference, hyperglycemia, elevated blood pressure and hyperlipidemia. With time, these conditions present a major risk of developing obesity, type 2 diabetes and atherosclerosis. Fecal microbiota transplant (FMT) experiments performed in mice have given an intriguing foundation for a microbial-based th

The European Union’s capacity for leadership is not just decided by the EU itself. It is also affected by the perceptions of other actors regarding the EU’s role, and by their reactions to its initiatives. The same can be said of the Union’s influence in the international arena, including its capacity to do something about global imbalances. Is the EU perceived as a legitimate actor that has somet

With the arrival of the refugees from the Middle East, especially since 2015, Europe has become a xenophobic hotbed. Discourses, practices, and policies promoting and supporting xenophobia have become reality. In this article, we seek to present stories of those who have arrived to Europea via the Balkan Route, in a qualitative research fashion, concentrating on several narratives collected by the

Hip-related pain is a well-recognised complaint among active young and middle-aged active adults. People experiencing hip-related disorders commonly report pain and reduced functional capacity, including difficulties in executing activities of daily living. Patient-reported outcome measures (PROMs) are essential to accurately examine and compare the effects of different treatments on disability in

The introductory chapter emphasises the general relevance of the study of electoral candidates in representative democracies. It presents the book’s theoretical framework: the triadic delegation and accountability relationship between candidates, voters and parties—based on principal–agent theory. We theoretically map patterns of candidates’ behaviour and attitudes in all main dimensions of their

Mergers of neutron stars (NS) and white dwarfs (WD) may give rise to observable explosive transientevents. We use 3D hydrodynamical (SPH) simulations, as well as 2D hydrodynamical-thermonuclearsimulations (using the FLASH AMR code) to model the disruption of CO-WDs by NSs, whichproduce faint transient events. We post-process the simulations using a large nuclear network andmake use of the SuperNu

In this paper we present the recent improvements for optically stimulated luminescence dosimetry using ordinary salt (NaCl). It is shown that the dosimetric properties of NaCl may be improved by compressing the salt grains to solid pellets. With a linear dose response in, at least, the region <100 mGy, a zero background signal (when pre-bleached) and a minimum measurable dose of 10-20 μGy and high

A combination of hydrogen/deuterium (H/D) exchange and limited proteolysis experiments coupled to mass spectrometry analysis was used to depict the conformation in solution of HAMLET, the folding variant of human alpha-lactalbumin, complexed to oleic acid, that induces apoptosis in tumor and immature cells. Although near- and far-UV CD and fluorescence spectroscopy were not able to discriminate be