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Antibody-based microarrays.

Antibody-based microarrays are a new powerful proteomic technology that can be used to generate rapid and detailed expression profiles of defined sets of protein analytes in complex samples as well as high-resolution portraits of entire proteomes. Miniaturized micro- and nanoarrays can be printed with numerous antibodies carrying the desired specificities. Multiplexed and ultra-sensitive assays, s

The Danish national return-to-work program - aims, content, and design of the process and effect evaluation

The Danish national return-to-work (RTW) program aims to improve the management of municipal sickness benefit in Denmark. A study is currently ongoing to evaluate the RTW program. The purpose of this article is to describe the study protocol. The program includes 21 municipalities encompassing approximately 19 500 working-age adults on long-term sickness absence, regardless of reason for sickness

Transient Access to the Protein Interior: Simulation versus NMR.

Many proteins rely on rare structural fluctuations for their function, whereby solvent and other small molecules gain transient access to internal cavities. In magnetic relaxation dispersion (MRD) experiments, water molecules buried in such cavities are used as intrinsic probes of the intermittent protein motions that govern their exchange with external solvent. While this has allowed a detailed c

Just us, just discussing: imagined homogeneities in the Gender Studies classroom

This article explores practices of othering through formations of normative sameness in discussion-based seminar classrooms. It takes literary scholar Stanley Fish’s question, ‘Is there a text in this class, or is it just us?’, back into the classroom to explore the formation of a ‘just us,’ an imagined homogeneous interpretive community which, I argue, has discriminatory effects by normalising so

Treatment of Parkinson's disease using cell transplantation.

The clinical trials with intrastriatal transplantation of human fetal mesencephalic tissue, rich in dopaminergic neurons, in Parkinson's disease (PD) patients show that cell replacement can work and in some cases induce major, long-lasting improvement. However, owing to poor tissue availability, this approach can only be applied in very few patients, and standardization is difficult, leading to wi

Bacterial Hydrolysis of Host Glycoproteins - Powerful Protein Modification and Efficient Nutrient Acquisition.

Glycoproteins are ubiquitous in nature and fundamental to most biological processes, including the human immune system. The glycoprotein carbohydrate moieties, or glycans, are very diverse in their structure and composition, and have major effects on the chemical, physical and biological properties of these glycoproteins. The hydrolysis of glycoprotein glycans by bacterial glycosidases can have dr

Age and reproduction in lesser spotted woodpeckers (Dendrocopos minor)

We examined the influence of female age, male age, and pair-bond duration on start of egg-laying, clutch size, and number of young fledged in the Lesser Spotted Woodpecker (Dendrocopos minor). We also attempted to disentangle the relative influence of individual age and pair-bond duration on reproduction, because the effect of those factors may be confounded. Brooding performance improved with age

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Detta är ett kapitel i en volym vars syfte är att studera det fantastiska i litteratur från olika delar av den fransktalande världen. Mitt bidrag handlar om fallet Patrick Chamoiseau som ett exempel på modern användning av det fantastiska i västindisk litteratur.This is a chapter in a volume whose aim is to study the fantastic in literature from different parts of the French speaking world. My contribution deals with the case of Patrick Chamoiseau as an example of the modern use of the fantastic in Carribean literature.

Diagnosis of tuberculous meningitis: a comparative analysis of 3 immunoassays, an immune complex assay and the polymerase chain reaction

OBJECTIVE: To compare 3 immunoassays, an immune complex assay, and an application of the polymerase chain reaction (PCR) for the diagnosis of tuberculous meningitis (TBM). MATERIAL: Cerebrospinal fluid (CSF) from 33 patients with TBM and from 34 control patients with infectious and non-infectious CNS diseases was analysed. RESULTS: The antibody immunoassays were either nonspecific or insensitive.

Modeling of Hindered Diffusion in Gels

Popular Abstract in Swedish Ordet diffusion kommer från det latinska ordet diffu´sio som betyder spridning. Diffusion förekommer nästan överallt, även om man inte alltid kan se det. Exempelvis består all den luft som vi andas in av en mängd molekyler som diffunderar fram och tillbaka. Eller så kan det vara vattenmolekyler som diffunderar in till plåten på bilen och gör så att den rostar, eller varHindered diffusion occurs in the most different processes, as has been described in this thesis. It is very important to have an understanding of the influence of hindered diffusion on the mass transfer rate, especially when competing rate processes are acting simultaneously. Using mathematical modeling and simulation makes it possible to predict the effects of hindered diffusion. The systems that