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We analyze public-policy speeches in the Florentine Consulte e Pratiche, immediately prior to the Ciompi Revolt, for signs of elite factional conflict, in the context of self-proclaimed unity. We employ three statistical analyses of these speeches in Latin: namely, scatterplots of word frequencies, Wordfish scaling, and regressions on speech-similarities. Plus we employ two qualitative analyses: a

BACKGROUND: This study sought to characterize a cohort of talar neck and body fractures, focusing on fracture characteristics, associated injuries, treatment and outcome.METHODS: We reviewed adult patients registered in the Swedish Fracture Register 2011-2021 with talar neck and body fractures. A minimum 2-year follow-up was conducted for treatment outcomes.RESULTS: We included 313 patients (318 f

Purpose: The purpose of this research paper is to study the promotion of non-profitable products by exploring the greater good initiatives of country branding in terms of brand identity and brand image. Design/methodology/approach: The research paper takes a qualitative approach and combines primary and secondary data. The primary data was collected through an interview. The secondary data is bas

Uppsatsens syfte har varit att kritiskt granska den svenska debatten kring DNA-analys för asylsökande barns rätt till familjeåterförening i Sverige och därmed se ifall principen om barnets bästa, definierat i svenska rättsakter, efterföljs. Genom den vägledande domen från Migrationsöverdomstolen den 18 januari 2012 fastslogs att DNA-analys kan användas för att styrka biologiskt släktskap med förälThe aim of this thesis has been to do a critical review on the Swedish debate concerning the use of DNA-tests to secure the rights of asylum-seeking children to be reunited with their families and if the principle of the best interests of the child is followed. The 18th of January 2012, in a precedent ruling, the Swedish Migration Court of Appeal concluded that DNA-test could be used to prove biol

HAMLET (human alpha-lactalbumin made lethal to tumor cells) is a tumoricidal complex consisting of partially unfolded protein and fatty acid, and was first identified in casein fractions of human breast milk. The complex can be produced from its pure components through a modified chromatographic procedure where pre-applied oleic acid binds with partially-unfolded alpha-lactalbumin on the stationar

Systemic lupus erythematosus (SLE) is an autoimmune disease involving many organ systems. The cause is not known, but a complex combination of environmental and genetic factors seems to be involved. In SLE upregulation of type I interferons, a hyperactive B-cell response, presence of autoantibodies against modified nuclear components, increased complement consumption, increased apoptosis and decre

Selective immunoglobulin A deficiency is the most common primary immunodeficiency disorder that is strongly overrepresented among patients with celiac disease (CD). IgG antibodies against tissue transglutaminase (tTG) and deamidated gliadin peptides (DGP) serve as serological markers for CD in IgA deficient individuals, although the diagnostic value remains uncertain. The aim of this study was to

Host defense peptides have recently gained much interest as novel anti-infectives owing to their ability to kill bacteria and simultaneously modulate host cell responses. The cationic host defense peptide GKY25 (GKYGFYTHVFRLKKWIQKVIDQFGE), derived from the C terminus of human thrombin, inhibits proinflammatory responses in vitro and in vivo, but the mode of action is unclear. In this study, we sho

Recent studies have identified a number of transcriptional regulators, including E2A, early B-cell factor 1 (EBF1), FOXO1, and paired box gene 5 (PAX5), that promote early B-cell development. However, how this ensemble of regulators mechanistically promotes B-cell fate remains poorly understood. Here we demonstrate that B-cell development in FOXO1-deficient mice is arrested in the common lymphoid

Popular Abstract in Swedish Huden och slemhinnor (mukosa) fungerar som kroppens skyddsbarriärer mot yttre angrepp av mikrober, makromolekyler och toxiner och förhindrar dessa att nå inre organ. Trots ett massivt immunskydd sker de flesta infektioner på slemhinnornas ytor. I blodcirkulationen förekommer fem olika typer av vita blodkroppar, alla med olika roller i immunförsvaret. I varje blod finns Mucosal infections trigger an inflammatory response that includes the secretion of cytokines and the recruitment of neutrophils to the infected site. This thesis describes studies examining the molecular mechanisms of neutrophil migration to sites of mucosal bacterial infection. Escherichia coli (E. coli) infection of epithelial cell layers stimulates chemokine secretion and chemokine receptor ex

Popular Abstract in Swedish Streptococcus pyogenes (GAS) är en viktig sjukdomsframkallande bakterie som orsakar alltifrån lindriga infektioner som halsfluss (tonsillit) och svinkoppar (impetigo) till livshotande djupa infektioner som nekrotiserande fasceit eller ”Toxic shock syndrom”. På grund av det snabba sjukdomsförloppet i de livshotande infektionerna har streptokockerna fått beteckningen ”mörA distinguishing feature of Streptococcus pyogenes (GAS) is their ability to resist phagocytosis in whole human blood in the absence of type-specific antibodies, a property that is dependent on the expression of the surface associated M proteins. A common characteristic of M proteins is their interaction with a variety of host proteins including the complement regulatory protein factor H (FH) and

Insulin sensitivity and secretion are related in a curvilinear inverse asymptotic function. However, the signaling factors mediating this relation are not known. In this study, we explored whether circulating glucose, lipids or two adipocyte-derived hormones, leptin and adiponectin, are related to the curvilinear function between insulin sensitivity and secretion in subjects with normal glucose to

In cystic fibrosis (CF) colonization of the airways with Pseudomonas aeruginosa is a major cause of deterioration and death. Host defence fails to clear the invading bacteria, which results in a chronic destructive inflammatory process. This thesis deals with factors in the interaction between bacteria and host defence that determine the extent of tissue damage caused by the bacteria. (I) Autoant

The respiratory pathogen Moraxella catarrhalis is a human-specific commensal that frequently causes acute otitis media in children and stimulates acute exacerbations in chronic obstructive pulmonary disease patients. The exact molecular mechanisms defining host-pathogen interactions promoting pathogenesis are not clearly understood. Limited knowledge hampers vaccine and immunotherapeutic developme

The demand for gas turbines suitable for Low Btu gases is increasing worldwide. This paper presents a theoretical and experimental investigation of the flammability limits of Low Btu gases for gas turbine applications. Most modern gas turbines utilize premixed combustion, making it important to know at which fuel-air ratio the flame extinguishes. The flammability limit for a gaseous fuel is a prop

Popular Abstract in Swedish Hypens grammatik informationsteknologi i återberättandet som myt, praktiserad verklighet och vetenskaplig analys alternativt IT-hypen åren innan och omkring millennieskiftet i väntan på nästa hype och nästa och nästa ... Detta är titeln på min avhandling, som snarare fokuserar på en speciell ”hype” än att den tar upp informationssamhället som sådant. I detta fall, hypeThe Grammar of The Hype digital information technology -IT- in retelling as myth its experienced reality and in scientific analysis or the IT-hype in the years prior to and at the turn of the millennium waiting for the next hype and the next, and“next”... This is the title of my thesis and it focuses rather on a particular “hype” than deals with the so-called information society as such. What is

The human genome sequence encodes fewer proteins than expected, suggesting that one protein can have several functions and adjust their structure to meet different structural demands. Changes in tertiary structure have mostly been associated with disease and the most striking example is the prion protein, which changes from a mixed alpha-helical and beta-sheet conformation to the beta-sheet rich,

Hereditary complete deficiency of complement component C1q is associated with a high prevalence of systemic lupus erythematosus and increased susceptibility to severe recurrent infections. An 11-year-old girl was screened for immunodeficiency due to a history of recurrent meningitis and pneumonia. Immunologic studies revealed absence of classic pathway hemolytic activity and undetectable levels of