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Insulin sensitivity and secretion are related in a curvilinear inverse asymptotic function. However, the signaling factors mediating this relation are not known. In this study, we explored whether circulating glucose, lipids or two adipocyte-derived hormones, leptin and adiponectin, are related to the curvilinear function between insulin sensitivity and secretion in subjects with normal glucose to

In cystic fibrosis (CF) colonization of the airways with Pseudomonas aeruginosa is a major cause of deterioration and death. Host defence fails to clear the invading bacteria, which results in a chronic destructive inflammatory process. This thesis deals with factors in the interaction between bacteria and host defence that determine the extent of tissue damage caused by the bacteria. (I) Autoant

Popular Abstract in Swedish Hypens grammatik informationsteknologi i återberättandet som myt, praktiserad verklighet och vetenskaplig analys alternativt IT-hypen åren innan och omkring millennieskiftet i väntan på nästa hype och nästa och nästa ... Detta är titeln på min avhandling, som snarare fokuserar på en speciell ”hype” än att den tar upp informationssamhället som sådant. I detta fall, hypeThe Grammar of The Hype digital information technology -IT- in retelling as myth its experienced reality and in scientific analysis or the IT-hype in the years prior to and at the turn of the millennium waiting for the next hype and the next, and“next”... This is the title of my thesis and it focuses rather on a particular “hype” than deals with the so-called information society as such. What is

Recent studies have identified a number of transcriptional regulators, including E2A, early B-cell factor 1 (EBF1), FOXO1, and paired box gene 5 (PAX5), that promote early B-cell development. However, how this ensemble of regulators mechanistically promotes B-cell fate remains poorly understood. Here we demonstrate that B-cell development in FOXO1-deficient mice is arrested in the common lymphoid

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Two series of C3-benzamido and O2-anion-substituted galactopyranosides were synthesized and studied as binders to arginine-rich proteins galectin-1, -3, -7, -8N (N-terminal domain), and -9N (N-terminal domain). The first series had a 4-methylbenzamide at C3 and the anionic O2-substituent was varied. The second series varied the 4-substituent of the C3-benzamide, whereas the anionic O2 substituent

Energy consumption reduction is today an important design issue for all kinds of digital systems. Offering both flexibility and efficient energy management, variable speed processor architectures are prefered for low energy consumption even in hard real-time systems. For this type of systems, the main approach consists in trading speed for lower energy while meeting all deadlines. For tasks with v

In our research we investigate rational agent which consciously balances deliberation and acting, and uses learning to augment its reasoning. It creates several partial plans, uses past experience to choose the best one and, by executing it, gains new knowledge about the world. We analyse a possible application of Inductive Logic Programming to learn how to evaluate partial plans in a resource-con

Popular Abstract in Swedish Bakgrund Avsikten med denna studie har varit att värdera om det idag föreligger tecken som tyder på att utvecklingen av diagnostiska hjälpmedel och behandlingsmetoder vid cancer i bukspottkörteln har åtföljts av en förbättrad prognos, samt att värdera vilken roll rökning och magsårsoperation kan ha för uppkomsten av sjukdomen. Pancreascancer, cancer i bukspottkörteln, The objective of this thesis has been to assess whether there are indications suggesting that new methods for diagnosis and treatment of pancreatic carcinoma (PCa) has been followed by an improved prognosis, and to assess the possible role of smoking and gastric resection in the causation of the disease. Of the 1,200 new cases PCa diagnosed in Sweden yearly, the majority are older than 70 years,

Popular Abstract in SwedishDenna studie utgår från tanken att ett samhälle kan ses som en grupp individer förenade i ett nätverk av sociala relationer. Nyckeln till förståelsen av samhället ligger därför i studiet av dessa sociala nätverk som den praktik (mikronivå) vari de sociala strukturerna (makronivån) reproduceras och förändras.Syftet med studien är att utifrån de sociala nätverken studera hThe aim of the study is to examine, using the social networks as a starting-point, the way a local community is constructed in a specific historical context, namely the industrial community of Limhamn in southern Sweden at the time of the Industrial Revolution 1870-1914. In 1870 the Skånska Cement Company initiated a large-scale extraction of limestone in the area and soon had cement works built i

The attitude of teachers towards students can vary substantially in relation to different factors, such as educational background, pedagogical training, teaching methods, etc. In this paper, we explore the impact of negative role-models on future teaching. In particular, past experiences of teachers as students as well as the contextual influence of other teachers on their future teaching has been

BackgroundPeople with intellectual disability have been found to have higher prevalence of psychiatric disorders than the general population. However, they do not seem to have a corresponding increase in psychiatric care utilization. The aim of the present study was to investigate psychiatric care utilization among older people with intellectual disability.MethodsWe used a cohort of people with in

Solvents are commonly used in pharmaceutical and cosmetic formulations and sanitary products and cleansers. The uptake of solvent into the skin may change the molecular organization of skin lipids and proteins, which may in turn alter the protective skin barrier function. We herein examine the molecular effects of 10 different solvents on the outermost layer of skin, the stratum corneum (SC), usin